Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Finding and exploiting interesting paths in multidimensional information spaces. This project will invent a new approach for searching within a large complex information space, finding interesting paths between points within the space, visualising the results, and supporting rich, human-centric user interaction with queries and results. This project will embody these techniques in a novel, internet-scale framework to support rapid development of large path search and visualisation applications. ....Finding and exploiting interesting paths in multidimensional information spaces. This project will invent a new approach for searching within a large complex information space, finding interesting paths between points within the space, visualising the results, and supporting rich, human-centric user interaction with queries and results. This project will embody these techniques in a novel, internet-scale framework to support rapid development of large path search and visualisation applications. Evaluation will be via development of several exemplar applications. The techniques and framework will be applicable to a broad range of economically important problems in areas as diverse as health, travel, scientific publication search, product marketing and software engineering.Read moreRead less
How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, ....How enhancers regulate T cell differentiation and function. This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, this project expects to provide insights into non-coding regulatory element reprogramming and control of immune cell function and memory with implications for understanding general cellular differentiation.Read moreRead less
Special Research Initiatives - Grant ID: SR0354693
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in ....Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in other RNs linking to their motivating applications, enhancing prospects for research and integration. They participate in the APAC Grid program, leveraging 75 HPC staff nationally. A key aim is interoperability with "real-world Grids": eg e-learning & e-health programs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989347
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
CYCLOPS - A Better Way to Find Extrasolar Planets. The primary scientific driver for this new facility is the search for planets orbiting other stars. Australian astronomers, and the Anglo-Australian Telescope, have played a leading role in this new frontier for astronomy, detecting 25 of the 250-odd extrasolar planets known to orbit nearby stars. The CYCLOPS project brings together a team of leading Australian astronomers to build on this track record with a new facility that further advances A ....CYCLOPS - A Better Way to Find Extrasolar Planets. The primary scientific driver for this new facility is the search for planets orbiting other stars. Australian astronomers, and the Anglo-Australian Telescope, have played a leading role in this new frontier for astronomy, detecting 25 of the 250-odd extrasolar planets known to orbit nearby stars. The CYCLOPS project brings together a team of leading Australian astronomers to build on this track record with a new facility that further advances Australia's capabilities in both this field, and several other high-profile astronomical endeavours: including the study of seismology in stellar interiors, the detailed measurement of elemental abundances in stars throughout our Galaxy, and the mapping of spot features on the surfaces of stars.Read moreRead less
Three-dimensional structure determination of biomolecular assemblies from sparse data of different length scales. New computer algorithms will be combined with sparse experimental structure restraints, obtained with novel protein chemistry technologies, to generate accurate three-dimensional (3D) models of proteins and protein assemblies in solution and in the solid state. The new strategies will greatly increase the number of protein targets amenable to rational drug design.
Decision making for lifetime affordable and tenable city housing. This project will study home buying decisions and outcomes and use this to provide new insights into housing affordability and liveability. The project will develop an innovative software tool for Australia's home buyers to explore affordability and liveability during home buying, and agent-based modelling of scenarios for urban development futures.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100090
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Computational infrastructure for developing deep machine learning models. Computational infrastructure for developing deep machine learning models:
The computational infrastructure for developing deep machine learning models aims to enable new developments in machine learning of deep neural network models by providing the specialised computing necessary to train and evaluate the networks. In the last three years, deep networks have smashed previous performance ceilings for tasks such as object ....Computational infrastructure for developing deep machine learning models. Computational infrastructure for developing deep machine learning models:
The computational infrastructure for developing deep machine learning models aims to enable new developments in machine learning of deep neural network models by providing the specialised computing necessary to train and evaluate the networks. In the last three years, deep networks have smashed previous performance ceilings for tasks such as object recognition in images, speech recognition and automatic translation, bringing the prospect of machine intelligence closer than ever. Modern machine learning techniques have had huge impact in the last decade in fields such as robotics, computer vision and data analytics. The facility would enable Australian researchers to develop, learn and apply deep networks to problems of national importance in robotic vision and big data analytics. Read moreRead less
Special Research Initiatives - Grant ID: SR0354839
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Transforming Knowledge Spaces: Open Technologies for Research Collaboration and Research Communication
. Technology has the potential to transform the means for scholarly collaboration and communication. Our proposal will achieve this potential, by deploying open source infrastructures to create new communication platforms. The Initiative will itself use collaborative writing systems to construct and energise the Network, which will match researchers requiring these new technologies with thos ....Transforming Knowledge Spaces: Open Technologies for Research Collaboration and Research Communication
. Technology has the potential to transform the means for scholarly collaboration and communication. Our proposal will achieve this potential, by deploying open source infrastructures to create new communication platforms. The Initiative will itself use collaborative writing systems to construct and energise the Network, which will match researchers requiring these new technologies with those who have the skills to build them. The outcomes will be an increase in the efficiency of traditional research collaborations as well as new kinds of collaboration and communication, for researchers and consumers of research across a range of disciplines.Read moreRead less
Adaptive data stream processing in heterogeneous distributed computing environments using real-time context. This project falls within the ARC research priority goal, Smart Information Use. The innovative contributions of this project through the development of adaptive data stream mining algorithms for heterogeneous devices will have an impact on a range of emerging application areas such as:
1. Meeting time-critical, intelligent information needs of the mobile workforce (e.g. mobile healthca ....Adaptive data stream processing in heterogeneous distributed computing environments using real-time context. This project falls within the ARC research priority goal, Smart Information Use. The innovative contributions of this project through the development of adaptive data stream mining algorithms for heterogeneous devices will have an impact on a range of emerging application areas such as:
1. Meeting time-critical, intelligent information needs of the mobile workforce (e.g. mobile healthcare professionals, stockbrokers). 2. Improving Intelligent Transportation Systems via in-vehicle analysis and crash prevention. 3. Facilitating 'on-board' analysis in sensors that monitor the environment and patients. The project will enhance Australia's leading international role in the area of data stream processing in distributed computing environments.Read moreRead less