Discovery Early Career Researcher Award - Grant ID: DE200101323
Funder
Australian Research Council
Funding Amount
$427,098.00
Summary
Structure guided mapping of protein interactions and their perturbation. Protein interactions are central to most biological processes, and significant effort has been devoted to trying to unravel these complicated networks. This project aims to develop new approaches to better understand these interactions, and the consequences of their perturbation. The main expected contributions will be: (i) methods to identify likely protein interaction sites using population conservation; (ii) computationa ....Structure guided mapping of protein interactions and their perturbation. Protein interactions are central to most biological processes, and significant effort has been devoted to trying to unravel these complicated networks. This project aims to develop new approaches to better understand these interactions, and the consequences of their perturbation. The main expected contributions will be: (i) methods to identify likely protein interaction sites using population conservation; (ii) computational approaches to assess the effects of any type of mutation on the interaction; and (iii) an understanding of how disruption of a specific interaction can affect the complicated biological network within a cell. Read moreRead less
Flexible user-guided network layout for biomedical applications. This project will develop techniques for automatic layout of biological network diagrams, allowing users to guide the layout while satisfying any required placement constraints and drawing conventions. As part of the project, these methods will be integrated into several real-world systems biology applications for network browsing and authoring.
Smart algorithms for visual field assessment. Australian demographic studies show that visual impairment contributes significantly to elderly disability. Visual field loss due to glaucoma, the second leading cause of blindness in developed nations, may be slowed if detected early, but recent studies estimate 50% of Australians with glaucoma are undiagnosed. The fast and effective approaches to measuring visual fields discovered in this project will allow more accurate diagnosis and monitoring of ....Smart algorithms for visual field assessment. Australian demographic studies show that visual impairment contributes significantly to elderly disability. Visual field loss due to glaucoma, the second leading cause of blindness in developed nations, may be slowed if detected early, but recent studies estimate 50% of Australians with glaucoma are undiagnosed. The fast and effective approaches to measuring visual fields discovered in this project will allow more accurate diagnosis and monitoring of vision loss; crucial for the ARC's priority goals of "ageing well, ageing productively" and "preventative healthcare". Developing smart algorithms in conjunction with Heidelberg Engineering creates an opportunity for the international promotion of Australia's biomedical software capabilities.Read moreRead less
Uncovering microRNA decay regulation in mammalian cells. MicroRNAs (miRNAs) constitute a novel mechanism used by cells to regulate gene expression, however, very little is known about the mechanisms affecting miRNA accumulation. Characterisation of the kinetics of miRNA turnover is of paramount importance to establish the reliability of miRNAs as novel biomarkers. This project aims to characterise miRNA stability in mammalian cells, investigate mechanisms of turnover and establish their importan ....Uncovering microRNA decay regulation in mammalian cells. MicroRNAs (miRNAs) constitute a novel mechanism used by cells to regulate gene expression, however, very little is known about the mechanisms affecting miRNA accumulation. Characterisation of the kinetics of miRNA turnover is of paramount importance to establish the reliability of miRNAs as novel biomarkers. This project aims to characterise miRNA stability in mammalian cells, investigate mechanisms of turnover and establish their importance on the regulatory function of miRNAs. Such information is critical in the future development of targeted therapeutics.Read moreRead less
Domain-specific visual languages for big data analytics applications. This project aims to invent domain-specific visual languages and support model-driven engineering based infrastructure so domain experts can specify, generate and apply complex data analytics and visualisation techniques. Many domains, including intelligent transport, business intelligence, and population health, need more effective “big data” analytics and visualisation. A challenge is to combine detailed domain knowledge – w ....Domain-specific visual languages for big data analytics applications. This project aims to invent domain-specific visual languages and support model-driven engineering based infrastructure so domain experts can specify, generate and apply complex data analytics and visualisation techniques. Many domains, including intelligent transport, business intelligence, and population health, need more effective “big data” analytics and visualisation. A challenge is to combine detailed domain knowledge – what the data means and what it can be used for – with sophisticated, scalable computational techniques to mine and present information from the huge volumes of raw data. This project is expected to improve productivity and quality of big data analytics and visualisation in critical domains.Read moreRead less
Metamorphic slices and their applications in fault localization. The main purpose of this project is to enhance the quality of software. The expected outcomes include the delivery of new cost-effective methods to debug software, and the extension of current debugging methods to be applicable in wider contexts.
Integration of Metamorphic Testing and Model Checking. This project proposes an innovative approach of integrating metamorphic testing and model checking. Its main outcome will be to deliver a comprehensive testing method that will help to reduce errors and costs in software development and consequently to improve the quality of software systems. Since software is pervasive and ubiquitous, our results will improve the nation's software productivity and quality. Thus, our results will help in ra ....Integration of Metamorphic Testing and Model Checking. This project proposes an innovative approach of integrating metamorphic testing and model checking. Its main outcome will be to deliver a comprehensive testing method that will help to reduce errors and costs in software development and consequently to improve the quality of software systems. Since software is pervasive and ubiquitous, our results will improve the nation's software productivity and quality. Thus, our results will help in raising our nation's competitive advantage towards the goal of becoming a leading nation in the software industry among Asia-Pacific countries. Furthermore, this collaboration will help young Australian researchers to link to the Chinese Academy of Sciences, a leading-edge international research institute.Read moreRead less
Metamorphic Testing: An In-Depth Study to Enhance the Failure-Detection Capability of Software Testing Without an Oracle. Nowadays, software is pervasive and ubiquitous. It plays a significant role in the daily lives of all kinds of people. The Australian software industry has bloomed in recent years. Our research results will improve the cost-effectiveness of software development, thereby upgrading the nation's software productivity and quality. These factors are conducive to the export of soft ....Metamorphic Testing: An In-Depth Study to Enhance the Failure-Detection Capability of Software Testing Without an Oracle. Nowadays, software is pervasive and ubiquitous. It plays a significant role in the daily lives of all kinds of people. The Australian software industry has bloomed in recent years. Our research results will improve the cost-effectiveness of software development, thereby upgrading the nation's software productivity and quality. These factors are conducive to the export of software produced by Australians and helpful in raising our nation's competitive advantage towards the goal of becoming a leading nation in the software industry among Asia-Pacific countries.Read moreRead less
A Comprehensive Testing Methodology for Embedded Software. Embedded systems are a bedrock technology for many high-technology industries. They are used in many safety-critical situations, such as medical devices and car control systems, amongst hundreds of other applications. Unfortunately, current practice still sometimes results in disastrous mistakes remaining undetected, leading to multi-million dollar losses and in some cases even deaths. Improved testing methods for these systems offer ....A Comprehensive Testing Methodology for Embedded Software. Embedded systems are a bedrock technology for many high-technology industries. They are used in many safety-critical situations, such as medical devices and car control systems, amongst hundreds of other applications. Unfortunately, current practice still sometimes results in disastrous mistakes remaining undetected, leading to multi-million dollar losses and in some cases even deaths. Improved testing methods for these systems offer the potential of reducing such catastrophic losses. Improved embedded system testing techniques can offer Australia a competitive advantage in this strategically important industry. We will work to distribute our results to the Australian embedded systems community.Read moreRead less
Failure-Based Testing: An In-Depth Theoretical and Experimental Study. Nowadays, software is pervasive and ubiquitous. It plays a significant role in the daily lives of all kinds of people. The Australian software industry has bloomed in recent years. Our research results will improve the cost-effectiveness of software development, thereby upgrading the nation's software productivity and quality. These factors are conducive to the export of software produced by Australians and helpful in raising ....Failure-Based Testing: An In-Depth Theoretical and Experimental Study. Nowadays, software is pervasive and ubiquitous. It plays a significant role in the daily lives of all kinds of people. The Australian software industry has bloomed in recent years. Our research results will improve the cost-effectiveness of software development, thereby upgrading the nation's software productivity and quality. These factors are conducive to the export of software produced by Australians and helpful in raising our nation's competitive advantage towards the goal of becoming a leading nation in the software industry among Asia-Pacific countries.Read moreRead less