A Vulvar Cancer Cluster In Young Indigenous Women In Arnhem Land: Investigation Of Community Knowledge, Genetic Susceptibility And Supportive Care Response
Funder
National Health and Medical Research Council
Funding Amount
$711,841.00
Summary
Cancer of the vulva is 50 times more common in young Aboriginal women in Arnhem Land than in other women. Human Papillomavirus (HPV), which also causes cervical cancer, is the usual cause of this cancer; initial investigations have found that HPV is present in these cancers but is not the reason for the excessive incidence. This study will investigate local knowledge about this disease, and whether inherited susceptibility or an environmental cancer-causing substance are the cause of the excess.
There is increasing evidence that regular physical activity contributes considerably to better physical fitness and good health of individuals and nations. Unfortunately, many individuals in Australia are not regularly active. A sedentary lifestyle is associated with a higher risk of coronary heart disease, obesity, diabetes, osteoporosis and some cancers. Physical activity guidelines encourage participation in at least 30 minutes of moderate-intensity physical activity on most, preferably all, ....There is increasing evidence that regular physical activity contributes considerably to better physical fitness and good health of individuals and nations. Unfortunately, many individuals in Australia are not regularly active. A sedentary lifestyle is associated with a higher risk of coronary heart disease, obesity, diabetes, osteoporosis and some cancers. Physical activity guidelines encourage participation in at least 30 minutes of moderate-intensity physical activity on most, preferably all, days of the week. Walking is one of the most common forms of physical activity undertaken by adults, however there is a relatively poor understanding of the physiological demands of this task. A better understanding of walking for people of different age, gender, size and shape would provide for improvements in the categorisation of intensity of physical activity for use in population measures of physical activity and exercise prescription for individuals who are obese. The aim of the proposed study is to assess the relationship between energy cost of walking and body composition of adults. The main purpose is to consider how people of different age, gender, size and shape manage self-paced walking relative to maximal capacity. The energy cost of walking is an important determinant of a person's functional capacity, physical fitness and health status. The main outcomes of the study: An increased knowledge and understanding of the energy expenditure of self-paced walking relative to maximal aerobic power; More reliable assessment of physical activity status using a variety of commonly employed indirect assessment techniques; A comprehensive understanding of the inter-individual differences in walking characteristics based on age, gender or body fatness; A better understanding of the energy cost of walking and the subsequent promotion of this form of physical activity has potential to impact on the health of Australians, particularly those who are sedentary and overweight or obese.Read moreRead less
Supported Treadmill Training To Establish Walking In Non-ambulatory Patients Early After Stroke
Funder
National Health and Medical Research Council
Funding Amount
$341,349.00
Summary
This project will improve the health and well being of people affected by stroke. Stroke is the most common disabling neurological condition in adults and consumes up to 5% of health care expenditure in developed countries, estimated by the National Stroke Foundation at $1-2 billion per year in Australia. Some 48,000 people suffer a stroke each year in Australia, with approximately one third of these people requiring inpatient rehabilitation and 70% of them are unable to walk on admission to reh ....This project will improve the health and well being of people affected by stroke. Stroke is the most common disabling neurological condition in adults and consumes up to 5% of health care expenditure in developed countries, estimated by the National Stroke Foundation at $1-2 billion per year in Australia. Some 48,000 people suffer a stroke each year in Australia, with approximately one third of these people requiring inpatient rehabilitation and 70% of them are unable to walk on admission to rehabilitation. This randomised controlled trial will investigate whether treadmill walking with partial weight support via an overhead harness is effective at establishing independent walking (i) more often, (ii) earlier and (iii) with a better quality of walking, than current treatment for stroke patients who cannot walk. We will measure (i) whether patients achieve independent walking and (ii) the time taken to achieve independent walking. We will also measure parameters of walking such as speed, step length and step width to evaluate the effect of treadmill training on the quality of walking. Furthermore, by measuring participation in the community at 6 months, we will evaluate the long-term effect of this innovative treatment. Given that independence in walking is a major factor in the decision to discharge patients from inpatient care, earlier independent walking should result in a reduction in length of hospital stay which will save about $800 per patient per day in a teaching hospital setting. Identifying rehabilitation strategies which enhance walking outcome will not only improve quality of life of both stroke patients and their carers by reducing disability and handicap but also reduce the cost of rehabilitation.Read moreRead less
A Multicentre Randomised Clinical Trial Of Physical Activity For The Treatment Of Patients With Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$773,752.00
Summary
The number of older adults living with Alzheimer's disease (AD) will increase from 26.6 million to 106.2 million by 2050. In the absence of curative treatment options it is important to focus on non-pharmacological interventions such as physical activity. We propose to investigate whether a home-based physical activity program of 24 weeks for patients with AD can successfully decrease the rate of cognitive and functional declince and improve quality of life and psychological well-being.
Social Aspects And Cultural Meanings Of Gynaecological Cancer Diagnosis, Treatment And Adjustment Of Victorian Women
Funder
National Health and Medical Research Council
Funding Amount
$158,500.00
Summary
Most research worldwide concerning gynaecological cancers has related to cervical cancer screening because of the effectiveness of Pap tests, while limited research has been conducted on social aspects of cancer. However, cancer of the uterus and ovary are among the top ten cancers in Australian women, and the diagnosis of a gynaecological cancer has a profound effect on women. This study is concerned with women's understandings of cancer disease, its treatment and outcomes, and with social fact ....Most research worldwide concerning gynaecological cancers has related to cervical cancer screening because of the effectiveness of Pap tests, while limited research has been conducted on social aspects of cancer. However, cancer of the uterus and ovary are among the top ten cancers in Australian women, and the diagnosis of a gynaecological cancer has a profound effect on women. This study is concerned with women's understandings of cancer disease, its treatment and outcomes, and with social factors that may influence their treatment decisions and care. The study will be conducted in metropolitan and rural Victoria. Women from a variety of ethnic, language and social backgrounds, who have been diagnosed with gynaecological cancer in the preceding three years, will be interviewed to gain insight into their understandings and experiences of the processes of disease, diagnosis and treatment procedures, the implications of for daily life, and the relationship of these events to their perceptions of their bodies, gender and sexuality. We will also interview oncologists and cancer support group facilitators, and participate in cancer support groups, to examine the role of such groups and to explore the experiences of health professionals providing care to women with these cancers. Research findings will be used to develop health educational information about gynaecological cancers, and to provide information to hospitals and clinicians to improve quality of clinical care and social support.Read moreRead less
Eco-RESIDE: An Economic Evaluation Of Urban Design As A Means Of Promoting Physical Activity
Funder
National Health and Medical Research Council
Funding Amount
$422,612.00
Summary
The significance of this project lies in the health problem that it seeks to address and the intervention that is being evaluated. Physical inactivity ranks second only to tobacco use in terms of the costs of diseases associated with behavioural risk factors. Declining rates of physical activity have been associated with increasing rates of obesity and overweight in Australian children and adults. The association that one sees between features of the urban environment and physical activity level ....The significance of this project lies in the health problem that it seeks to address and the intervention that is being evaluated. Physical inactivity ranks second only to tobacco use in terms of the costs of diseases associated with behavioural risk factors. Declining rates of physical activity have been associated with increasing rates of obesity and overweight in Australian children and adults. The association that one sees between features of the urban environment and physical activity levels suggests that urban planning guidelines may be a cost-effective means of promoting health and achieving other social objectives such as sustainable use of natural resources. Furthermore, not enough is known about the economic value of investing in health promoting interventions and this project is among the first to measure the costs and benefits of intervening at the environmental level. The information that it provides will be highly useful for local government and health service planners alike.Read moreRead less
A Randomised Clinical Trial Of Physical Activity For The Treatment Of Older Adults With Mild Cognitive Impairment
Funder
National Health and Medical Research Council
Funding Amount
$280,250.00
Summary
Australia's population is aging rapidly and so is the frequency of age-related diseases. Dementia and depression are the most frequent mental health disorders of older people. They are also the leading causes of years of life lost due to disability in Australia. The results of recent studies have shown that memory difficulties and dementia are associated with potentially modifiable risk factors, such as physical activity. The purpose of this study is to investigate whether a physical activity pr ....Australia's population is aging rapidly and so is the frequency of age-related diseases. Dementia and depression are the most frequent mental health disorders of older people. They are also the leading causes of years of life lost due to disability in Australia. The results of recent studies have shown that memory difficulties and dementia are associated with potentially modifiable risk factors, such as physical activity. The purpose of this study is to investigate whether a physical activity program for older adults decreases cognitive decline and conversion to dementia in a population at risk: mild cognitive impairment (MCI). 168 subjects with MCI will be randomised (by chance, like the flip of a coin) to either the intervention program of physical activity or usual care - their cognitive (such as memory) performance will be compared at the end of 24 months.Read moreRead less