Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560751
Funder
Australian Research Council
Funding Amount
$432,474.00
Summary
Facility for the Analysis of Biomacromolecular Interactions. A facility for the analysis of biological macromolecules and their interactions with ligand molecules is required to support a large number of research projects in high priority areas including mechanisms of aging, drug development and bio/nanotechnology at three different universities. The instrumentation will (i) afford quantitative measurements of binding affinities between biological and chemical macromolecules, which are available ....Facility for the Analysis of Biomacromolecular Interactions. A facility for the analysis of biological macromolecules and their interactions with ligand molecules is required to support a large number of research projects in high priority areas including mechanisms of aging, drug development and bio/nanotechnology at three different universities. The instrumentation will (i) afford quantitative measurements of binding affinities between biological and chemical macromolecules, which are available only in small quantities, and small, drug related molecules (by microcalorimetry and dual polarization interferometry), and (ii) provide equipment necessary for sample characterization and purification prior to quantitative measurements (CD spectroscopy, and FPLC equipment).Read moreRead less
Assessing the adaptive capacity of hospital facilities to cope with climate-related extreme weather events: A risk management approach. Given Australia's and New Zealand's relatively high exposure to climate extremes, the social, economic and health benefits of better managed hospital facilities are significant. Floods, bushfires, heatwaves and cyclones cost Australia over $1.4bn/year and New Zealand over NZ$43m/yr in disruption to communities, business productivity and damage to infrastructure. ....Assessing the adaptive capacity of hospital facilities to cope with climate-related extreme weather events: A risk management approach. Given Australia's and New Zealand's relatively high exposure to climate extremes, the social, economic and health benefits of better managed hospital facilities are significant. Floods, bushfires, heatwaves and cyclones cost Australia over $1.4bn/year and New Zealand over NZ$43m/yr in disruption to communities, business productivity and damage to infrastructure. This research will help to mitigate these costs by protecting populations from the health risks associated with such events. The potential benefits will be most significant for those vulnerable communities at high risk such as the aged, the obese, the ill and those geographically exposed to more extreme weather events.Read moreRead less
Special Research Initiatives - Grant ID: SR0567460
Funder
Australian Research Council
Funding Amount
$85,000.00
Summary
Development of a collaborative environment for high throughput biology discovery pipelines. Modern biological science involves the parallel high-throughput investigation of many hundreds of different experimental targets. Traditional approaches for recording, analysing, mining and cross comparing experimental data are inadequate for conducting high throughput experiments. This proposal aims to develop new algorithms in the high throughput arena that will revolutionize biological discovery.
POLYMER-BASED COATINGS TO INCREASE THE SURVIVAL OF MICROBIAL INOCULANTS APPLIED TO AGRICULTURAL SEEDS. World-wide, there is much active research to maximise the use of Rhizobium for legumes and to develop a new range of growth-promoting micro-organisms for application to agricultural crops including cereals. However, very poor survival of inoculant bacteria after application to seed severely limits their effectiveness. New polymer coatings on seed may enhance survival of inoculants. By collabora ....POLYMER-BASED COATINGS TO INCREASE THE SURVIVAL OF MICROBIAL INOCULANTS APPLIED TO AGRICULTURAL SEEDS. World-wide, there is much active research to maximise the use of Rhizobium for legumes and to develop a new range of growth-promoting micro-organisms for application to agricultural crops including cereals. However, very poor survival of inoculant bacteria after application to seed severely limits their effectiveness. New polymer coatings on seed may enhance survival of inoculants. By collaboration between chemists, rhizobiologists and the inoculant and seed-coating industries, innovative technology can now be generated, improving inoculum potential, giving higher crop yields using less fertilisers. The technology will generate a rural service industry providing coated seed products that reduce farmers' input costs and help maximise their income.Read moreRead less
Mathematical Methods for Next Generation Sequencing. The emergence of a new generation of high throughput genomic sequencing technologies is providing unprecedented opportunities for biological research. Hidden within the huge amounts of data generated by this technology is information about the expression and regulation of genes, and the complex functional purpose of non-coding, so called 'junk', DNA. Development of mathematical and statistical tools is essential to interpreting these data. The ....Mathematical Methods for Next Generation Sequencing. The emergence of a new generation of high throughput genomic sequencing technologies is providing unprecedented opportunities for biological research. Hidden within the huge amounts of data generated by this technology is information about the expression and regulation of genes, and the complex functional purpose of non-coding, so called 'junk', DNA. Development of mathematical and statistical tools is essential to interpreting these data. The proposed research will enhance Australia's reputation for developing novel quantitative techniques at the cutting edge of modern biology. The proposed project has a broad range of potential applications in biotechnology, particularly in the medical and agricultural industries.Read moreRead less
Disulfide Bonds and Protein Folding. This work will advance our understanding of protein folding, which has important implications in biotechnology, impacting on commercial production of recombinant proteins (for pharmaceutical and biomedical applications) and on 1000s of research laboratories worldwide that use recombinant technologies. This research could also contribute to medicine (new treatments for diseases of protein misfolding like Alzheimer's), and to membrane protein structural biology ....Disulfide Bonds and Protein Folding. This work will advance our understanding of protein folding, which has important implications in biotechnology, impacting on commercial production of recombinant proteins (for pharmaceutical and biomedical applications) and on 1000s of research laboratories worldwide that use recombinant technologies. This research could also contribute to medicine (new treatments for diseases of protein misfolding like Alzheimer's), and to membrane protein structural biology. This work could yield economic benefits in the long-term through patentable outcomes and will benefit the community by producing high impact research papers, providing training to Australians and forging links with renowned international scientists.Read moreRead less
Natural Hazard Vulnerability: A study of risk, vulnerability, behaviour, attitudes and perceptions of warnings. This project builds on original research into community vulnerability, awareness and preparedness for natural hazards. During the second half of the United Nations International Decade for Natural Disaster Reduction, the trend in emergency management and disaster mitigation research has been towards the social and community impacts of natural disasters. The aim of the project is to exa ....Natural Hazard Vulnerability: A study of risk, vulnerability, behaviour, attitudes and perceptions of warnings. This project builds on original research into community vulnerability, awareness and preparedness for natural hazards. During the second half of the United Nations International Decade for Natural Disaster Reduction, the trend in emergency management and disaster mitigation research has been towards the social and community impacts of natural disasters. The aim of the project is to examine risk perception amongst hazard vulnerable communities. The expected outcomes include an improved awareness campaign and a better understanding of the ways in which warnings and forecasts are filtered and distorted by the public.Read moreRead less
Green roofs - improving urban environments in a changing climate. Green roofs are an emerging climate change adaptation technology that is widespread in Europe and North America, but rare and untested in Australia. Our research will significantly progress the Australian green roof industry by overcoming barriers to their implementation. This will lead to multiple environmental, economic and health benefits at a variety of scales. Benefits for individual buildings include greater energy efficienc ....Green roofs - improving urban environments in a changing climate. Green roofs are an emerging climate change adaptation technology that is widespread in Europe and North America, but rare and untested in Australia. Our research will significantly progress the Australian green roof industry by overcoming barriers to their implementation. This will lead to multiple environmental, economic and health benefits at a variety of scales. Benefits for individual buildings include greater energy efficiency, increased roof life and the attenuation of noise. Environmental benefits include biodiversity habitat, reduced volume and improved quality of stormwater flows and cooling of the urban environment. This will further reduce energy use and greenhouse emissions, while reducing human health risks during heat waves.Read moreRead less
A functional genomic approach for understanding metal ion adaptation in marine cyanobacteria. Unicellular marine cyanobacteria constitute 20-40% of total marine chlorophyll biomass and carbon fixation, and hence significantly impact the global carbon cycle and are very relevant to combating global warming. This research will reveal some of the major mechanisms by which marine cyanobacteria have adapted to metal levels in coastal and oligotrophic environments. Thus these results will help us und ....A functional genomic approach for understanding metal ion adaptation in marine cyanobacteria. Unicellular marine cyanobacteria constitute 20-40% of total marine chlorophyll biomass and carbon fixation, and hence significantly impact the global carbon cycle and are very relevant to combating global warming. This research will reveal some of the major mechanisms by which marine cyanobacteria have adapted to metal levels in coastal and oligotrophic environments. Thus these results will help us understand the distribution and diversity of these organisms in relation to global primary productivity. They will also lead to the development of more robust biomarkers for metal stress and pollution in coastal environments.Read moreRead less
Organisation, expression and diversity of the sub-telomeric regions of the ancient eukaryote, Giardia duodenalis. We propose to extend our findings on the extreme plasticity of the structure and organisation of the sub-telomeric region of the complete genome of Giardia by more extensive chromosome walking, and comparison of different isolates. These regions are subject to gene conversion, transcriptional silencing, gene mobility, recombination, variable surface protein expression, subtelomeric i ....Organisation, expression and diversity of the sub-telomeric regions of the ancient eukaryote, Giardia duodenalis. We propose to extend our findings on the extreme plasticity of the structure and organisation of the sub-telomeric region of the complete genome of Giardia by more extensive chromosome walking, and comparison of different isolates. These regions are subject to gene conversion, transcriptional silencing, gene mobility, recombination, variable surface protein expression, subtelomeric instability and the insertion of transposable elements, a dynamic balance between structural conservation and rapid evolution. This is a rare opportunity to understand the forces at work in moulding eukaryotic sub-telomeric sequences because Giardia is not constrained by sexual homogenisation and the dynamic variability is retained.Read moreRead less