Managing infectious disease through partial wildlife social networks. This project aims to investigate the dynamics of the spread of infectious disease in wildlife, derived from incomplete information about contact networks. Infectious diseases in wildlife are difficult to track and control, because it is not feasible to monitor each individual in a population and know the contact network for a population. The project will create ways to best utilise incomplete observational data of contact netw ....Managing infectious disease through partial wildlife social networks. This project aims to investigate the dynamics of the spread of infectious disease in wildlife, derived from incomplete information about contact networks. Infectious diseases in wildlife are difficult to track and control, because it is not feasible to monitor each individual in a population and know the contact network for a population. The project will create ways to best utilise incomplete observational data of contact networks to develop robust predictions of disease spread and population fate, and to reliably predict the outcomes of management interventions. These robust prediction methods will provide better insights for conservation of Australian wildlife.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL100100183
Funder
Australian Research Council
Funding Amount
$2,168,370.00
Summary
Biological adaptation under natural and anthropogenic conditions. This project covers all four national priority areas. Nature abounds with conflicts between what is good for the individual or a larger entity (a population, a society, or a species). Researching them will explain why populations adapt or fail to adapt to novel conditions (e.g., climate change) and predict when interventions are beneficial. Similar rules govern the spread of invasive species. Even health problems, e.g., new virule ....Biological adaptation under natural and anthropogenic conditions. This project covers all four national priority areas. Nature abounds with conflicts between what is good for the individual or a larger entity (a population, a society, or a species). Researching them will explain why populations adapt or fail to adapt to novel conditions (e.g., climate change) and predict when interventions are beneficial. Similar rules govern the spread of invasive species. Even health problems, e.g., new virulent strains of human, animal or plant diseases, require such evolutionary thinking. Cutting-edge mathematical tools also prepare Australians for an era in the near future where genomic data are so cheap to acquire that training in complex mathematical and logical analysis becomes a factor limiting scientific progress.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101791
Funder
Australian Research Council
Funding Amount
$427,082.00
Summary
Mathematically optimal R&D for coral reef conservation. This project aims to develop mathematical methodologies for optimising Research & Development (R&D) of technologies that will secure complex and uncertain ecosystems into the future. Current conventional management approaches will not prevent the degradation of threatened ecosystems like the Great Barrier Reef, so new technologies are needed. The biggest challenge in choosing these technologies is the long delay between development and depl ....Mathematically optimal R&D for coral reef conservation. This project aims to develop mathematical methodologies for optimising Research & Development (R&D) of technologies that will secure complex and uncertain ecosystems into the future. Current conventional management approaches will not prevent the degradation of threatened ecosystems like the Great Barrier Reef, so new technologies are needed. The biggest challenge in choosing these technologies is the long delay between development and deployment, in which time ecosystem function may collapse and complex, dynamic ecological and social systems will change. The mathematical methods and theory developed will inform a Great Barrier Reef case study, and will be ready for rapid application to other ecosystems as the urgent need arises.Read moreRead less
Alternative Splicing in the Mouse Transcriptome. Although the human genome completion is cause for excitement we do not have any firm indication of precisely how many protein-coding genes exist in a mammalian genome. We have even less indication of the extent to which these genes generate alternative gene products, through a process termed alternative splicing. The detection and sequencing of these full-length alternative gene products is the focus of this application. This application details t ....Alternative Splicing in the Mouse Transcriptome. Although the human genome completion is cause for excitement we do not have any firm indication of precisely how many protein-coding genes exist in a mammalian genome. We have even less indication of the extent to which these genes generate alternative gene products, through a process termed alternative splicing. The detection and sequencing of these full-length alternative gene products is the focus of this application. This application details the opportunity to participate in the identification of the full transcriptome of the mouse and is part of a collaborative effort with The RIKEN Genome Sciences Center in Japan.Read moreRead less
How calcium makes the heart grow. This project aims to develop a mathematical model of calcium signalling in heart cells to understand how calcium makes the heart grow. Our hearts grow to adapt to long-term changes, such as during development and in pregnancy or heart disease. Biochemical reactions involving calcium control the growth of heart cells and heart cells also use calcium signalling to trigger contraction with each beat. How calcium controls the heartbeat and regulates cell growth is u ....How calcium makes the heart grow. This project aims to develop a mathematical model of calcium signalling in heart cells to understand how calcium makes the heart grow. Our hearts grow to adapt to long-term changes, such as during development and in pregnancy or heart disease. Biochemical reactions involving calcium control the growth of heart cells and heart cells also use calcium signalling to trigger contraction with each beat. How calcium controls the heartbeat and regulates cell growth is unknown. This project will develop a new mathematical model of calcium signalling in heart cells to understand important cellular adaption processes. This knowledge will lead to the ability to independently control cellular pathways mediated by calcium, opening new avenues in biotechnology and biomedicine.Read moreRead less
Mathematical models and bioinformatic analyses of bacterial genome evolution. Bacteria are vital agents in earth's biosphere, breaking down and synthesising a wide variety of compounds. Some bacteria cause disease; others are exploited for a range of biotechnological applications. Bacteria have a remarkable ability to survive and thrive in changing conditions. For example, pathogenic bacteria confronted by antibiotics easily evolve resistance to them. With the reality of climate change, we expec ....Mathematical models and bioinformatic analyses of bacterial genome evolution. Bacteria are vital agents in earth's biosphere, breaking down and synthesising a wide variety of compounds. Some bacteria cause disease; others are exploited for a range of biotechnological applications. Bacteria have a remarkable ability to survive and thrive in changing conditions. For example, pathogenic bacteria confronted by antibiotics easily evolve resistance to them. With the reality of climate change, we expect more rapid shifts in the structure of bacterial communities, possibly leading to the emergence of new pathogens. The benefits of this project are to discover how the genetic structure of bacteria confer this flexibility, and to help keep Australia at the forefront of research in bioinformatics and mathematical biology.
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Social insect behaviour: the importance of individual-decision making and information transfer. Insect societies are complex systems. Understanding complex systems is often hampered by our inability to study the individual units that comprise the system without also disturbing the system. Insect societies are unique in that the individual insects can be studied within their natural setting. This project will study foraging behaviour of honey bees with respect to individual decision-making and in ....Social insect behaviour: the importance of individual-decision making and information transfer. Insect societies are complex systems. Understanding complex systems is often hampered by our inability to study the individual units that comprise the system without also disturbing the system. Insect societies are unique in that the individual insects can be studied within their natural setting. This project will study foraging behaviour of honey bees with respect to individual decision-making and information transfer. In doing so we will obtain insights in the working of other, less accessible, complex systems such as the mammalian brain or the Australian economy.Read moreRead less
Understanding animals through their movement. This project aims to develop a suite of analytical methods to understand animals' behaviour through their movement patterns. Animal movement patterns encode detailed information about their behavioural state. Collecting and analysing animal movement trajectories can provide us with completely new insights to behaviour. Recent developments in bio-logging technologies have provided an incredible amount of rich data on free-ranging animals. This project ....Understanding animals through their movement. This project aims to develop a suite of analytical methods to understand animals' behaviour through their movement patterns. Animal movement patterns encode detailed information about their behavioural state. Collecting and analysing animal movement trajectories can provide us with completely new insights to behaviour. Recent developments in bio-logging technologies have provided an incredible amount of rich data on free-ranging animals. This project will develop a suite of analytical techniques to interrogate this data through a combination of approaches, from fine scale experiments in the laboratory to tracking animal trajectories from the International Space Station. The findings will deliver major benefits to the broader community by transforming our ability to manage and conserve animal stocks.Read moreRead less
Statistical methods for detection of non-coding RNAs in eukaryote genomes. Understanding how eukaryotic cells work is a major goal of 21st century biology. A crucial step will be to catalogue the functional components of eukaryotic genomes. Australian researchers must be involved in this process at an early stage, in order to maximise commercial opportunities, attract quality researchers and position ourselves for further advances. This project will make major contributions to international effo ....Statistical methods for detection of non-coding RNAs in eukaryote genomes. Understanding how eukaryotic cells work is a major goal of 21st century biology. A crucial step will be to catalogue the functional components of eukaryotic genomes. Australian researchers must be involved in this process at an early stage, in order to maximise commercial opportunities, attract quality researchers and position ourselves for further advances. This project will make major contributions to international efforts in this area, via the development of statistical methods for segmenting genomes, classification of those segments, and study of the resulting classes. In the long term, enhanced understanding of eukaryotic cells will lead to breakthroughs in biology, and to medical, pharmaceutical, agricultural and scientific advances.Read moreRead less
Statistical methods and tools for integrative microarray analysis. Tools used for biological and medical research have been evolving and there has been an increase in high-throughput technologies such as genome sequencing and DNA microarray. The growing number of entries and the increasing availability of public microarray repositories and other sequence databases have generated the new challenge of developing tools to efficiently integrate data by different research groups. This research provi ....Statistical methods and tools for integrative microarray analysis. Tools used for biological and medical research have been evolving and there has been an increase in high-throughput technologies such as genome sequencing and DNA microarray. The growing number of entries and the increasing availability of public microarray repositories and other sequence databases have generated the new challenge of developing tools to efficiently integrate data by different research groups. This research provides new statistical methods to integrate different data sets. Its application in the biomedical field will allow researchers to effectively interpret the myriad of data generated within the community.Read moreRead less