Renewable energy generation from flow-induced vibration. Much engineering effort has been expended to eliminate vibration of marine structures. This project seeks to provide the basis for the development of tidal energy harnessing, by deliberately amplifying and harnessing vibration. This technology offers the promise of capturing clean, zero-emissions energy, while presenting no risk to marine life.
The social determinants of childhood injury. Child hood injury is a preventable problem of major importance. This project will provide a comprehensive, research-based policy solution that will minimise death and disability among children zero to three years of age.
Development of Control Methodologies for Drug Dosing in Biomedical Engineering. This research proposal is very relevant to the National Research Priorities in the areas of Frontier Technologies and Breakthrough science. At a broader level, we aim to assist in the development of a national competence in what has been an emerging and promising discipline. The research will develop fundamental and enabling laws and techniques for drug administration to regulate physiological variables such as blood ....Development of Control Methodologies for Drug Dosing in Biomedical Engineering. This research proposal is very relevant to the National Research Priorities in the areas of Frontier Technologies and Breakthrough science. At a broader level, we aim to assist in the development of a national competence in what has been an emerging and promising discipline. The research will develop fundamental and enabling laws and techniques for drug administration to regulate physiological variables such as blood pressure and degree of consciousness in critical care patients.Read moreRead less
Hybridisation leading to lost sex: genomic and experimental insights. The project intends to apply advanced genomics to two classic Australian systems and quantitative genetics to one to address long-standing questions about why asexual reproduction is rare. It aims to test for rapid changes in genomes accompanying hybrid-origins of asexuals and whether this new diversity enables their ongoing evolution. The significance is that support for this hypothesis would challenge current theory for why ....Hybridisation leading to lost sex: genomic and experimental insights. The project intends to apply advanced genomics to two classic Australian systems and quantitative genetics to one to address long-standing questions about why asexual reproduction is rare. It aims to test for rapid changes in genomes accompanying hybrid-origins of asexuals and whether this new diversity enables their ongoing evolution. The significance is that support for this hypothesis would challenge current theory for why sex is so common. The expected outcome is to understand how variation is generated in natural populations with different ways of reproducing. Benefits would include significant contributions to global science, evolutionary training and potential applications in using hybridisation to manage threatened species or pests.Read moreRead less
Applying search theory for eradicating invasive species. Invasive species have major economic and environmental impacts in Australia and are a major cause of extinctions worldwide. Monitoring is crucial for the timely control of invasive species in sensitive environments. Early detection increases the probability of eradication and increased accuracy in detection reduces the impact of control programs on non-target species. Efficient monitoring also is crucial in determining whether eradication ....Applying search theory for eradicating invasive species. Invasive species have major economic and environmental impacts in Australia and are a major cause of extinctions worldwide. Monitoring is crucial for the timely control of invasive species in sensitive environments. Early detection increases the probability of eradication and increased accuracy in detection reduces the impact of control programs on non-target species. Efficient monitoring also is crucial in determining whether eradication has succeeded. Search Theory has been applied for over 60 years in a wide range of non-biological monitoring problems, resulting in large increases in target detection rates. Gains of a similar magnitude in invasive species detection would greatly enhance Australia's capacity to manage these threats.Read moreRead less
Mathematical, logical and computational foundations of hybrid control systems, and their application to design and synthesis problems in control engineering. Hybrid control systems are mathematical models of heterogeneous systems consisting of digital computer components interacting in real-time with continuous physical processes. Their many engineering applications include air traffic control, medical technology and automated transport. Motivated by such safety-critical and high-confidence appl ....Mathematical, logical and computational foundations of hybrid control systems, and their application to design and synthesis problems in control engineering. Hybrid control systems are mathematical models of heterogeneous systems consisting of digital computer components interacting in real-time with continuous physical processes. Their many engineering applications include air traffic control, medical technology and automated transport. Motivated by such safety-critical and high-confidence applications, the project aims to develop a unified framework of mathematical logics adequate to formally represent and reason about the structure, behaviour, and properties of hybrid control systems, and use this to develop methodologies for automatically synthesising hybrid control programs that are provably correct with respect to their specifications. Other outcomes include prototype software implementations of hybrid controller design tools.Read moreRead less
Mechanisms of colour production and the evolution of animal signals. This project aims to reveal how diverse colours are produced in reptiles and the information these colours convey about individual health, condition and performance. The project evaluates how stress affects both pigment deposition and the nano-structure of cells and tissues, which together produce colour. By comparing similar colours generated by two entirely different classes of pigment (carotenoids and pteridines), this proje ....Mechanisms of colour production and the evolution of animal signals. This project aims to reveal how diverse colours are produced in reptiles and the information these colours convey about individual health, condition and performance. The project evaluates how stress affects both pigment deposition and the nano-structure of cells and tissues, which together produce colour. By comparing similar colours generated by two entirely different classes of pigment (carotenoids and pteridines), this project will provide new insights into the evolution of animal coloration, and will significantly enhance our understanding of pteridines, one of the most prevalent but least understood classes of pigment in vertebrates.Read moreRead less
Tectonic Reconstruction of the Evolution of the Alpine-Himalayan Orogenic Chain. This project will construct a computationally explicit model of movements in the solid Earth for the past 150 million years, to study the Earth as a complex system during the collision that produced the Alpine-Himalayan mountain belt. This is the youngest collisional mountain belt on Earth, and at times it stretched from Spain to New Zealand. Earth Scientists want to understand the processes that took place to mak ....Tectonic Reconstruction of the Evolution of the Alpine-Himalayan Orogenic Chain. This project will construct a computationally explicit model of movements in the solid Earth for the past 150 million years, to study the Earth as a complex system during the collision that produced the Alpine-Himalayan mountain belt. This is the youngest collisional mountain belt on Earth, and at times it stretched from Spain to New Zealand. Earth Scientists want to understand the processes that took place to make it, in particular the role of ribbon continents. As a result of this work ordinary Australians will be able to better perceive their interactions with their nearest neighbours.Read moreRead less
Design of Real-time Optimisation Methods with Guaranteed Performance. The project aim is the development of a framework for the advancement of optimisation algorithms operating in real-time applications. This project expects to generate new knowledge in the area of systems theory and optimisation, and its application to time-varying problems. Expected outcomes of this project should lead to a new theoretical and practical framework that aims to ameliorate the shortcomings of the existing approac ....Design of Real-time Optimisation Methods with Guaranteed Performance. The project aim is the development of a framework for the advancement of optimisation algorithms operating in real-time applications. This project expects to generate new knowledge in the area of systems theory and optimisation, and its application to time-varying problems. Expected outcomes of this project should lead to a new theoretical and practical framework that aims to ameliorate the shortcomings of the existing approaches that struggle to rapidly respond to new information. This should provide significant benefits. Specifically, this project aims to facilitate a technological leap that generates smaller, faster, and more powerful embedded systems such as broadband services, mobile phones, medical imagining, radar and avionics.Read moreRead less
Physiology of oxygen transport in the mammalian kidney. This project aims to improve understanding of oxygen regulation in renal tissue and knowledge of the physiology of the kidney. The mammalian kidney receives more oxygen than it uses or needs, and yet renal tissue is commonly found to be hypoxic. This project proposes that oxygen transport to the renal tissue is limited by blood vessel surface area. The project expects to generate anatomical data currently missing from the renal physiology c ....Physiology of oxygen transport in the mammalian kidney. This project aims to improve understanding of oxygen regulation in renal tissue and knowledge of the physiology of the kidney. The mammalian kidney receives more oxygen than it uses or needs, and yet renal tissue is commonly found to be hypoxic. This project proposes that oxygen transport to the renal tissue is limited by blood vessel surface area. The project expects to generate anatomical data currently missing from the renal physiology community, and potentially change the accepted story of oxygen homeostasis in the kidney. This will provide significant benefits, such as the provision of the foundational physiological science behind a determinant of kidney health and its flow-on impact to quality of life.Read moreRead less