Discovery Early Career Researcher Award - Grant ID: DE210101235
Funder
Australian Research Council
Funding Amount
$424,500.00
Summary
Encounters with hominins: the history of human arrival in Sahul. This project aims to provide a detailed understanding on the remarkably complex encounters between archaic and modern human populations in Island Southeast Asia, New Guinea and Australia during the Pleistocene. The project plans to provide the largest collection of human genetic diversity from this vast geographical region and significantly advance current knowledge on one of the most intriguing questions in human evolution. These ....Encounters with hominins: the history of human arrival in Sahul. This project aims to provide a detailed understanding on the remarkably complex encounters between archaic and modern human populations in Island Southeast Asia, New Guinea and Australia during the Pleistocene. The project plans to provide the largest collection of human genetic diversity from this vast geographical region and significantly advance current knowledge on one of the most intriguing questions in human evolution. These insights are expected to bring important social and cultural benefits for Australia by unveiling the singularly deep genetic history of Aboriginal Australians, including their ancient connection to indigenous communities from Indonesia and New Guinea that extends back to when people first arrived in Australia.
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Discovery Early Career Researcher Award - Grant ID: DE190101069
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Adaptation and diversification of the first peoples of Sahul. This project aims to further advance work on the genetic history of Indigenous Australians and Papuans that has revealed that Aboriginal Australians have inhabited a variety of diverse and challenging environments for approximately 50,000 years. Using novel techniques for extraction of human DNA from soil and the use of cutting-edge graph-based methods, hundreds of Indigenous Australian and Papuan genomes will be analysed. This projec ....Adaptation and diversification of the first peoples of Sahul. This project aims to further advance work on the genetic history of Indigenous Australians and Papuans that has revealed that Aboriginal Australians have inhabited a variety of diverse and challenging environments for approximately 50,000 years. Using novel techniques for extraction of human DNA from soil and the use of cutting-edge graph-based methods, hundreds of Indigenous Australian and Papuan genomes will be analysed. This project expects to generate new knowledge by filling in the gaps in the Australian genetic record via ancient human DNA from sediments. Expected outcomes from this project are producing a detailed picture of genomic adaptation in Indigenous Australians and Papuans and creating a comprehensive genetic history of the First Peoples of Sahul.Read moreRead less
Evolution and mechanisms of interactions in biofilm communities. This project aims to study the long-term experimental evolution of a mixed species bacterial biofilm community. This project expects to gain understanding of the genetic and physiological basis of community evolution. Expected outcomes of this project will be an understanding of how synthetic communities evolve. This will significantly benefit the use of synthetic communities relevant to fields such as antibiotic design, biotechnol ....Evolution and mechanisms of interactions in biofilm communities. This project aims to study the long-term experimental evolution of a mixed species bacterial biofilm community. This project expects to gain understanding of the genetic and physiological basis of community evolution. Expected outcomes of this project will be an understanding of how synthetic communities evolve. This will significantly benefit the use of synthetic communities relevant to fields such as antibiotic design, biotechnology, bioremediation, and synthetic biology where evolution can be inhibited or exploited, respectively.Read moreRead less
Optimising plant populations for ecological restoration and resilience. When choosing individual plants for restoration populations, there is potentially a trade-off between maximising genetic diversity (‘adaptability’) and selection for desirable properties (‘adaptation’). This project aims to develop pioneering methods to quantify this trade-off, and facilitate the design of optimised populations, with a focus on two Australian rainforest trees that are being impacted by myrtle rust infection: ....Optimising plant populations for ecological restoration and resilience. When choosing individual plants for restoration populations, there is potentially a trade-off between maximising genetic diversity (‘adaptability’) and selection for desirable properties (‘adaptation’). This project aims to develop pioneering methods to quantify this trade-off, and facilitate the design of optimised populations, with a focus on two Australian rainforest trees that are being impacted by myrtle rust infection: Rhodamnia argentea and Rhodamnia rubescens. By studying the genetic variation in each species, and how this relates to myrtle rust resistance and climate, this project aims to design populations that are genetically diverse, maximally resistant to myrtle rust, and adapted to future climate.Read moreRead less
Transitions between modes of sex-determination in a changing world. Sex-determination controls the largest variation within animals—the division into males and females. While the different systems of sex-determination—involving genetic or environmental control—are fairly well understood, transitions between these systems remain enigmatic in evolutionary biology. This project aims to address this gap by revealing the molecular change required to transition between systems, using one of only two k ....Transitions between modes of sex-determination in a changing world. Sex-determination controls the largest variation within animals—the division into males and females. While the different systems of sex-determination—involving genetic or environmental control—are fairly well understood, transitions between these systems remain enigmatic in evolutionary biology. This project aims to address this gap by revealing the molecular change required to transition between systems, using one of only two known lizard species exhibiting both genetic and temperature control of sex. This knowledge will have important implications for species conservation, facilitating predictions of highly biased sex ratios under climate change, plus potential commercial applications for species where production of one sex is favoured.Read moreRead less
Uncovering an evolutionary advanced mechanism of gene expression control. This project aims to uncover a new mechanism that activates gene expression in mammals, which involves unexpected connections between the core components of chromosomes and essential enzymatic machines required for the expression of genes. This project will generate new knowledge on the poorly understood process of how the extensive genomic information of multicellular organisms is selectively chosen to enable the expressi ....Uncovering an evolutionary advanced mechanism of gene expression control. This project aims to uncover a new mechanism that activates gene expression in mammals, which involves unexpected connections between the core components of chromosomes and essential enzymatic machines required for the expression of genes. This project will generate new knowledge on the poorly understood process of how the extensive genomic information of multicellular organisms is selectively chosen to enable the expression of only the required subset of genes. This will revolutionise our understanding of the mechanisms of gene control thereby shaping the field in the future. Significantly, this will allow new ways to manipulate gene expression that will impact biotechnology by providing new efficient ways to produce proteins or RNA. Read moreRead less
Targeting the genome and epigenome of the exercising skeletal muscle. This project aims is to discover epigenetic and genetic biomarkers that predict fitness changes, following exercise intervention. Individuals are remarkably variable in their responses to exercise interventions, and a large portion of these responses is attributed to genetics, and epigenetics (the effect of the environment on the expression of genes). Using controlled exercise training as a model, this project expects to disco ....Targeting the genome and epigenome of the exercising skeletal muscle. This project aims is to discover epigenetic and genetic biomarkers that predict fitness changes, following exercise intervention. Individuals are remarkably variable in their responses to exercise interventions, and a large portion of these responses is attributed to genetics, and epigenetics (the effect of the environment on the expression of genes). Using controlled exercise training as a model, this project expects to discover epigenetic and genomic markers in skeletal muscle predictive of exercise adaptations. This will contribute to the development and future delivery of targeted and personalised exercise programs for the general population. This has important implications for improving health in the Australian population.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100184
Funder
Australian Research Council
Funding Amount
$425,000.00
Summary
Pioneering alpine epigenomics to discover adaptive genetic elements. The genetic code of native plants are yet to be explored for DNA elements that promote resilience to climate change. These elements are now ripe for discovery due to recent advances in epigenomics allowing for rapid identification. This proposal aims to discover heat-associated elements in waxy bluebells, which inhabit Australia’s vulnerable high country. Expected outcomes include new insights on gene regulatory mechanisms in n ....Pioneering alpine epigenomics to discover adaptive genetic elements. The genetic code of native plants are yet to be explored for DNA elements that promote resilience to climate change. These elements are now ripe for discovery due to recent advances in epigenomics allowing for rapid identification. This proposal aims to discover heat-associated elements in waxy bluebells, which inhabit Australia’s vulnerable high country. Expected outcomes include new insights on gene regulatory mechanisms in native plants; the generation of resources for genetic conservation, and catalysing further molecular research into Australian flora. This should provide significant benefits by revealing genome regulation in native plants, thereby improving the ability to predict the impacts of climate change.Read moreRead less
Nuclear RNA surveillance and its connection to splicing quality control. Due to the error-prone nature of RNA splicing, elaborate quality control processes ensure that only correctly spliced transcripts can leave the nucleus. It has long been known that incorrectly spliced mRNA transcripts are degraded by the nuclear RNA surveillance machinery, but how the RNA quality control machinery is connected to nuclear RNA surveillance is not known. This proposal aims to uncover the connection between the ....Nuclear RNA surveillance and its connection to splicing quality control. Due to the error-prone nature of RNA splicing, elaborate quality control processes ensure that only correctly spliced transcripts can leave the nucleus. It has long been known that incorrectly spliced mRNA transcripts are degraded by the nuclear RNA surveillance machinery, but how the RNA quality control machinery is connected to nuclear RNA surveillance is not known. This proposal aims to uncover the connection between these two important processes and will fill a significant gap in our understanding of how splicing quality control and nuclear RNA surveillance work. The project will also identify sequence features that trigger abortive splicing reactions and will thus help to improve the design of synthetic mRNAs.Read moreRead less
Can exercise slow down the epigenetic ageing clock? The aged population accounts for a significant amount of Australia’s health budget. This project aims to uncover novel molecular biomarkers that slow the ageing process and maintain good health for longer. This project aims to use innovative epigenetic analysis to study the molecular ‘clocks’ of young and old populations and to test whether exercise can slow the ageing process. This is expected to lead to a better understanding of how humans re ....Can exercise slow down the epigenetic ageing clock? The aged population accounts for a significant amount of Australia’s health budget. This project aims to uncover novel molecular biomarkers that slow the ageing process and maintain good health for longer. This project aims to use innovative epigenetic analysis to study the molecular ‘clocks’ of young and old populations and to test whether exercise can slow the ageing process. This is expected to lead to a better understanding of how humans respond to changing environments during their lifetime, and will underpin the development of evidence-based personalised health interventions to keep Australians healthier for longer.
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