Development of Pyrrolopyrimidines as Inhibitors of ATP-Binding Proteins. This project seeks to generate analogues of natural products that have been found to be active against cancer cells and tropical parasites. The new materials produced by this project will aid in the study of biochemical processes involved in diseases such as cancer and lymphatic filariasis, thus leading the way to development of these compounds as potential treatments for such diseases.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347962
Funder
Australian Research Council
Funding Amount
$218,000.00
Summary
Adelaide Mass Spectrometry and Analysis Facility. This joint proposal by two South Australian universities and the Hanson Institute seeks to establish a facility for rapid characterisation and identification of biomolecules by means of MALDI-TOF and Nano LC mass spectrometry. The requested equipment is not available in South Australia. This proposal would establish a Nano LC (Q-TOF) node at the University of Adelaide-University of South Australia location and a MALDI-TOF node at the Flinders loc ....Adelaide Mass Spectrometry and Analysis Facility. This joint proposal by two South Australian universities and the Hanson Institute seeks to establish a facility for rapid characterisation and identification of biomolecules by means of MALDI-TOF and Nano LC mass spectrometry. The requested equipment is not available in South Australia. This proposal would establish a Nano LC (Q-TOF) node at the University of Adelaide-University of South Australia location and a MALDI-TOF node at the Flinders location. Its presence would greatly enhance the quality of research and teaching in priority areas such as proteomics, bioinformatics and nanotechnology and would provide a basis for fostering university and biotechnology industry collaborations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0239035
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
Regional facility for surface and micro-structure analysis. Adelaide, Flinders and SA Universities seek to enhance the regional facility for surface and microstructure analysis. Equipment includes electron back scatter pattern imaging, high resolution coater, microprobe (CAMECA SX51) upgrade and X ray microtomography to be located at Adelaide University Centre for Electron Microscopy and Microstructure Analysis, the hub of the regional facility. The University of South Australia Ian Wark Researc ....Regional facility for surface and micro-structure analysis. Adelaide, Flinders and SA Universities seek to enhance the regional facility for surface and microstructure analysis. Equipment includes electron back scatter pattern imaging, high resolution coater, microprobe (CAMECA SX51) upgrade and X ray microtomography to be located at Adelaide University Centre for Electron Microscopy and Microstructure Analysis, the hub of the regional facility. The University of South Australia Ian Wark Research Institute node will house ToF-SIMS and SAM upgrades, the Flinders node a multimode STM atomic force microscope, and the Adelaide University Waite Campus node confocal xyz control and digital camera. Applications include biological, materials and geological research projects.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882289
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, ( ....New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, (ii) investigating the structure(s) of lipids (fats) in cardiovascular disease and cataract, (iii) developing anticancer drugs, and (iv) development of new materials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453973
Funder
Australian Research Council
Funding Amount
$696,093.00
Summary
Surface Spectroscopic and Microstructure Analysis. Funding is requested for an X-ray Photoelectron Spectrometer (XPS) and an Image Plate Guinier Camera (IPGC), to update and expand capabilities in surface spectroscopic and microstructural analysis of a wide range of materials. The XPS unit, to be located at the University of SA, will replace two 18-year old XPS units at UniSA and Flinders University. The IPGC is a new and unique instrument which will be located at the University of Adelaide. The ....Surface Spectroscopic and Microstructure Analysis. Funding is requested for an X-ray Photoelectron Spectrometer (XPS) and an Image Plate Guinier Camera (IPGC), to update and expand capabilities in surface spectroscopic and microstructural analysis of a wide range of materials. The XPS unit, to be located at the University of SA, will replace two 18-year old XPS units at UniSA and Flinders University. The IPGC is a new and unique instrument which will be located at the University of Adelaide. These items will be incorporated into the SA Regional Facility, which provides seamless access to instrumentation across nodes. Applications include materials science, geological and biological research projects.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989374
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
South Australian High-Resolution and Ion-Mobility Mass Spectrometry Facility. The analytical facility will enhance (i) fundamental research to understand the mechanisms of the reactions of charged species with neutral molecules, and (ii) the provision of structural information, including the precise atomic composition of any molecule, small or large. Research supported by this facility includes (a)nanotechnology, including supramolecular chemistry, (b) bioscience: cancer research, neurodegenera ....South Australian High-Resolution and Ion-Mobility Mass Spectrometry Facility. The analytical facility will enhance (i) fundamental research to understand the mechanisms of the reactions of charged species with neutral molecules, and (ii) the provision of structural information, including the precise atomic composition of any molecule, small or large. Research supported by this facility includes (a)nanotechnology, including supramolecular chemistry, (b) bioscience: cancer research, neurodegenerate diseases (e.g. Parkinson's disease) osteoarthritis, inflammation, cardiac diseases and synthetic approaches to anticancer and other drugs.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0346895
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
A Mass Directed Molecular Resolution Laboratory. The proposed "Mass Directed Molecular Resolution Laboratory" combines an integrated suite of instrumentation housed in purpose built laboratories with technical expertise to provide an unique "one stop shop" to meet the burgeoning mass spectrometry needs of the chemical community in the Melbourne area. This truly collaborative effort will service the needs of 17 research groups with 92 PhD students and post doctoral researchers and will enhance ex ....A Mass Directed Molecular Resolution Laboratory. The proposed "Mass Directed Molecular Resolution Laboratory" combines an integrated suite of instrumentation housed in purpose built laboratories with technical expertise to provide an unique "one stop shop" to meet the burgeoning mass spectrometry needs of the chemical community in the Melbourne area. This truly collaborative effort will service the needs of 17 research groups with 92 PhD students and post doctoral researchers and will enhance existing excellence in a range of areas. Finally, the laboratory will provide opportunities to: collaborate and consult with industry; train postgraduate students in instrumentation used at the cutting edge of chemical and biochemical sciences.Read moreRead less
The fate of dietary selenium in vivo; a direct approach to linking chemical form with biological activity. Dietary selenium supplementation has great potential as a preventative treatment for a range of human health conditions, including cancer, that widely affect the Australian population. However, the adverse effects of such treatments are not fully recognised. This project will increase our knowledge of how selenium compounds are stored and utilised in the body and relate the information to c ....The fate of dietary selenium in vivo; a direct approach to linking chemical form with biological activity. Dietary selenium supplementation has great potential as a preventative treatment for a range of human health conditions, including cancer, that widely affect the Australian population. However, the adverse effects of such treatments are not fully recognised. This project will increase our knowledge of how selenium compounds are stored and utilised in the body and relate the information to clinical observations regarding dietary intake of selenium and other compounds. The new understanding generated will delineate the conditions for safe intake, so that the beneficial effects associated with selenium supplementation may be harnessed more effectively.Read moreRead less
Gas Phase Reactivity of Charged Peptide and DNA Radicals: Fundamentals and Applications. Radicals derived from the "molecules of life", proteins and DNA, play both beneficial (e.g. enzyme catalysis) and deleterious roles (e.g. protein and DNA damage associated with disease). Two electrospray ionisation mass spectrometry approaches have been discovered to generate charged radicals of related models systems (e.g. peptides and nucleobases). The gas phase chemistry of these species is a largely unch ....Gas Phase Reactivity of Charged Peptide and DNA Radicals: Fundamentals and Applications. Radicals derived from the "molecules of life", proteins and DNA, play both beneficial (e.g. enzyme catalysis) and deleterious roles (e.g. protein and DNA damage associated with disease). Two electrospray ionisation mass spectrometry approaches have been discovered to generate charged radicals of related models systems (e.g. peptides and nucleobases). The gas phase chemistry of these species is a largely unchartered area! We will examine the fundamental chemistry (unimolecular and bimolecular reactions) of these systems and build upon some exciting preliminary results which suggest potential applications (e.g. as a proteomics tool to sequence and distinguish between leucine and isoleucine residues in peptides).Read moreRead less
New Methodology for the Stereoselective Construction of Oxygen Heterocycles and Rare Sugar Analogues. The overall goal of this research is to develop new synthetic methods, particularly ones that exhibit high levels of stereocontrol. Current research efforts are directed towards the stereoselective construction of oxygen heterocycles and rare sugar analogues both in their racemic and chiral forms utilising 1,2-dioxines containing tethered hydroxyl moieties as the key chemical precursors. It is e ....New Methodology for the Stereoselective Construction of Oxygen Heterocycles and Rare Sugar Analogues. The overall goal of this research is to develop new synthetic methods, particularly ones that exhibit high levels of stereocontrol. Current research efforts are directed towards the stereoselective construction of oxygen heterocycles and rare sugar analogues both in their racemic and chiral forms utilising 1,2-dioxines containing tethered hydroxyl moieties as the key chemical precursors. It is envisaged that these investigations will lead to the development of simple experimental protocols for the synthesis of new bioactive organics.Read moreRead less