Communication and information storage mechanisms in complex dynamical brain networks. Recordings of electrical activity in the brain often cycle repetitively. The aim of this research is to explain how these brain rhythms assist the brain to coordinate simultaneous activity in several regions. Australian socioeconomic benefits include: (i) contributions to the knowledge base of theoretical neuroscience, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of internation ....Communication and information storage mechanisms in complex dynamical brain networks. Recordings of electrical activity in the brain often cycle repetitively. The aim of this research is to explain how these brain rhythms assist the brain to coordinate simultaneous activity in several regions. Australian socioeconomic benefits include: (i) contributions to the knowledge base of theoretical neuroscience, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of international collaborations with Europe and Japan; (iii) outcomes will ultimately impact on improved medical bionics and future interfaces between brain activity and machines or computers; and (iv) commercialization and technology transfer opportunities, via the transfer of results to biologically inspired engineering.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100031
Funder
Australian Research Council
Funding Amount
$333,684.00
Summary
Mathematical modelling of the complex mechanics of biological materials and their role in tissue function and development. The mechanics of biological materials is complicated because they consist of many components such as fibres, proteins and polymers. We aim to use mathematical tools to understand how these components interact in tissues such as the spinal disc which will aid the development of new treatments to reverse the effects of injury, disease or aging.
Quantifying yeast cell mechanisms: filamentous growth and biofilm formation. This project aims to quantify the cellular mechanisms of yeast growth to advance our understanding of these organisms and support strategies to prevent and treat disease. Although yeasts are some of the most studied organisms in biology, their modes of filamentous growth and biofilm formation are not fully understood. Yeasts such as the Candida species cause potentially lethal infections through filamentous invasion of ....Quantifying yeast cell mechanisms: filamentous growth and biofilm formation. This project aims to quantify the cellular mechanisms of yeast growth to advance our understanding of these organisms and support strategies to prevent and treat disease. Although yeasts are some of the most studied organisms in biology, their modes of filamentous growth and biofilm formation are not fully understood. Yeasts such as the Candida species cause potentially lethal infections through filamentous invasion of tissues. The project plans to develop methods to quantify the mechanisms driving these growth processes. These methods will be designed to permit classification and selection of strain-specific properties of yeasts, providing a deeper understanding of the mechanisms controlling cellular and colonial morphology in the growth of Saccharomyces cerevisiae, the most important yeast in both biotechnology and bioscience.Read moreRead less
Fibre sensors with subwavelength features in the Terahertz radiation (T-ray) regime. With this program, Australia will benefit from expertise in photonics that will develop new chemical biosensors based on optical fibre technology. The novelty is that the fibres will be used to guide Terahertz radiation (T-ray) frequencies that will be able to detect very small samples of material or fluid. This is a fundamental step towards a system that will impact on applications in the medical, pharmaceutica ....Fibre sensors with subwavelength features in the Terahertz radiation (T-ray) regime. With this program, Australia will benefit from expertise in photonics that will develop new chemical biosensors based on optical fibre technology. The novelty is that the fibres will be used to guide Terahertz radiation (T-ray) frequencies that will be able to detect very small samples of material or fluid. This is a fundamental step towards a system that will impact on applications in the medical, pharmaceutical, forensic, and security industries. Ultimately, Australia will benefit from a new cutting-edge technology and a new diagnostic biosensing technique.Read moreRead less
A modelling challenge: bridging the gap between molecular and neuronal networks. We will develop innovative frameworks, which unify small-scale molecular activity with electrical signals in branches of brain cells. This research aims to enhance our understanding how molecular scale phenomena influence brain disease, via studying the model dynamics using cutting-edge techniques on a supercomputer. The socio-economic benefits to Australia include: (i) Enhancing Australia's international reputation ....A modelling challenge: bridging the gap between molecular and neuronal networks. We will develop innovative frameworks, which unify small-scale molecular activity with electrical signals in branches of brain cells. This research aims to enhance our understanding how molecular scale phenomena influence brain disease, via studying the model dynamics using cutting-edge techniques on a supercomputer. The socio-economic benefits to Australia include: (i) Enhancing Australia's international reputation for cutting-edge multidisciplinary research; (ii) international collaborations will be strengthened; (iii) outcomes will potentially lead to commercialisation opportunities; (iv) results will ultimately lay the foundations to explore the cellular and molecular origin of brain disorders.Read moreRead less
A lossy compression paradigm for sensory neural coding. By applying new interdisciplinary theoretical results, this research aims to enhance our understanding of how the ear turns sounds into electrical signals in the presence of high levels of random noise. Socio-economic benefits to Australia include: (i) contributions to the knowledge base of theoretical neuroscience, and communications systems, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of European interna ....A lossy compression paradigm for sensory neural coding. By applying new interdisciplinary theoretical results, this research aims to enhance our understanding of how the ear turns sounds into electrical signals in the presence of high levels of random noise. Socio-economic benefits to Australia include: (i) contributions to the knowledge base of theoretical neuroscience, and communications systems, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of European international collaborations; (iii) outcomes that will ultimately impact on improved designs for bionic ears and future biomedical prosthetics; and (iv) commercialisation and technology transfer opportunities, via the transfer of results to wireless artificial sensor networks.Read moreRead less
The evolution of species traits and spread during biological invasions. Exotic species pose a dire threat to Australia's biodiversity and natural resources due to the speed at which non-indigenous pests spread and the ecological and environmental damage they are capable of causing. The proposed research, on identifying traits associated with the spread of exotic vertebrate species and modelling the reproductive and dispersal parameters among different populations, will provide new knowledge and ....The evolution of species traits and spread during biological invasions. Exotic species pose a dire threat to Australia's biodiversity and natural resources due to the speed at which non-indigenous pests spread and the ecological and environmental damage they are capable of causing. The proposed research, on identifying traits associated with the spread of exotic vertebrate species and modelling the reproductive and dispersal parameters among different populations, will provide new knowledge and aid in developing innovative solutions for arresting the spread of exotic species. The validation of current models of spread will represent a major and timely addition to the national research capability on exotic species, and add substantially to Australia's reputation as a global leader in evolutionary ecology.Read moreRead less
Special Research Initiatives - Grant ID: SR0354716
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Energetically Open Systems Research Network Study. Conceptual frameworks arising in the physical sciences, such as non-equilibrium statistical mechanics and thermodynamics, synergetics, chaos and dynamical systems theory, are seminal in the emerging science of complexity. This study will lay the groundwork for a network to link Australian and overseas research on these fundamental concepts, and their application within the context of entropy-producing systems vital to the long-term sustainabilit ....Energetically Open Systems Research Network Study. Conceptual frameworks arising in the physical sciences, such as non-equilibrium statistical mechanics and thermodynamics, synergetics, chaos and dynamical systems theory, are seminal in the emerging science of complexity. This study will lay the groundwork for a network to link Australian and overseas research on these fundamental concepts, and their application within the context of entropy-producing systems vital to the long-term sustainability of the earth - oceans, atmosphere, biosphere, CO2-free energy production, space and solar environment. The network would facilitate the development of young investigators and be linked into wider complex systems networks such as the CSIRO Centre for Complex Systems Science.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100690
Funder
Australian Research Council
Funding Amount
$373,316.00
Summary
Mathematical modelling of the early stages of multicellular evolution. This project aims to develop new mathematical methodology to understand the early stages of the evolution of multicellular organisms from unicellular ancestors. This is the best known example of the creation of a new level of biological organisation. However, the early stages of this transition are poorly understood, especially how early groups of cells came to possess Darwinian characteristics, which then allows natural sele ....Mathematical modelling of the early stages of multicellular evolution. This project aims to develop new mathematical methodology to understand the early stages of the evolution of multicellular organisms from unicellular ancestors. This is the best known example of the creation of a new level of biological organisation. However, the early stages of this transition are poorly understood, especially how early groups of cells came to possess Darwinian characteristics, which then allows natural selection to act on them. It is anticipated that the models produced will be used to give the first mechanistic account of this intrinsically stochastic, multi-level, phenomenon. This may lead to new insights into the emergence and subsequent evolution of simple multicellular life cycles and early forms of development.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101486
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Animal groups as mobile sensor networks. This project aims to provide biologically inspired solutions to the problems faced by mobile sensor networks. Mobile sensor networks provide a powerful new tool in environmental monitoring and surveillance, however, designing them to be energy efficient while not sacrificing information detection remains a challenge. By immersing animal groups into dynamically changing virtual environments this project will design new efficient mobile sensor networks. The ....Animal groups as mobile sensor networks. This project aims to provide biologically inspired solutions to the problems faced by mobile sensor networks. Mobile sensor networks provide a powerful new tool in environmental monitoring and surveillance, however, designing them to be energy efficient while not sacrificing information detection remains a challenge. By immersing animal groups into dynamically changing virtual environments this project will design new efficient mobile sensor networks. The project is expected to provide solutions to mobile sensor network limitations, benefitting areas including robotics, environmental monitoring and defence.Read moreRead less