Paving the way for ultra-long haul flights: strategies to mitigate jetlag. This project aims to develop and test strategies to mitigate jetlag, founded on biophysical modelling of circadian rhythms. It sets out to quantify the speed of circadian adaptation of sleep, alertness, and metabolism after transmeridian travel and to maximise speed of adaptation via optimised timing of light exposure, food, and exercise in-flight and on-the-ground. Expected outcomes include powerful models for jetlag str ....Paving the way for ultra-long haul flights: strategies to mitigate jetlag. This project aims to develop and test strategies to mitigate jetlag, founded on biophysical modelling of circadian rhythms. It sets out to quantify the speed of circadian adaptation of sleep, alertness, and metabolism after transmeridian travel and to maximise speed of adaptation via optimised timing of light exposure, food, and exercise in-flight and on-the-ground. Expected outcomes include powerful models for jetlag strategies, ready for application in air travel. The project will directly inform Qantas’ operations for ultra-long haul flights and their international network more broadly. Project outcomes will benefit society and the economy through improving travellers’ alertness, sleep, and reducing the risk of fatigue-related accidents.Read moreRead less
Australia’s first direct-detection dark matter search, at Stawell Gold Mine. This project aims to develop an underground integrated laboratory at Stawell Gold Mine in Victoria to host the Southern Hemisphere's first-ever direct-detection dark matter experiment. Following the Higgs boson discovery, the direct detection of dark matter is seen as the next major challenge for particle physics. This project sees Australian physicists team up with local and international partners in research and indus ....Australia’s first direct-detection dark matter search, at Stawell Gold Mine. This project aims to develop an underground integrated laboratory at Stawell Gold Mine in Victoria to host the Southern Hemisphere's first-ever direct-detection dark matter experiment. Following the Higgs boson discovery, the direct detection of dark matter is seen as the next major challenge for particle physics. This project sees Australian physicists team up with local and international partners in research and industry to join the search for dark matter. This Australian experiment aims to help to confirm or deny current results from Northern Hemisphere experiments. As the mine nears the end of its working life as a gold mine, this project is expected to benefit the local economy and provide opportunities for education and outreach.Read moreRead less
Development of electrophoretic cell sorters. The aim of this research is to develop the next generation of cell sorters to scale production of viable sperm and other cell types. Our approach is to understand the factors that control the migration of cells in an electric field so that we can design large-scale devices to purify cells using electrophoretic separation. The outcomes of this research enable large-scale production of viable sperm for human and animal-assisted conception, benefiting in ....Development of electrophoretic cell sorters. The aim of this research is to develop the next generation of cell sorters to scale production of viable sperm and other cell types. Our approach is to understand the factors that control the migration of cells in an electric field so that we can design large-scale devices to purify cells using electrophoretic separation. The outcomes of this research enable large-scale production of viable sperm for human and animal-assisted conception, benefiting infertile couples and the livestock breeding industry. Successful development of an efficient cell separation technology would add significant commercial value to the Australian biomanufacturing sector. Read moreRead less
Towards non-thermal hydrogen-boron fusion. Laser-induced non-thermal fusion of hydrogen and boron 11 is a promising approach to reach practical sustainable energy generation. In addition, being aneutronic, this specific fusion reaction virtually avoids the deleterious environmental impact associated with high energy neutron radiation. The recent observation of this reaction under non-thermal conditions is not only exciting but begs for a better understanding of its dynamics. This industry suppor ....Towards non-thermal hydrogen-boron fusion. Laser-induced non-thermal fusion of hydrogen and boron 11 is a promising approach to reach practical sustainable energy generation. In addition, being aneutronic, this specific fusion reaction virtually avoids the deleterious environmental impact associated with high energy neutron radiation. The recent observation of this reaction under non-thermal conditions is not only exciting but begs for a better understanding of its dynamics. This industry supported proposal thus aims at establishing an experimentally-proven analysis framework underpinning the future development of a viable hydrogen-boron fusion reactor. In the long term, its successful implementation would constitute a sea change by providing a virtually limitless source of energy.Read moreRead less
Understanding molecular negative ion production for use in pathology. The project aims to increase the yield of molecular negative ion sources by improving our understanding of the formation of ion beams from plasma sources and expand our knowledge of molecular negative ion generation in plasma environments leading to brighter ion beams. For example, understanding cancer requires cellular level tools to map how cells are changing. These maps are made using ion beams which are scanned across cell ....Understanding molecular negative ion production for use in pathology. The project aims to increase the yield of molecular negative ion sources by improving our understanding of the formation of ion beams from plasma sources and expand our knowledge of molecular negative ion generation in plasma environments leading to brighter ion beams. For example, understanding cancer requires cellular level tools to map how cells are changing. These maps are made using ion beams which are scanned across cells to remove material that is analysed at the atomic and molecular level. Ion beams are produced from plasma sources, but much of their operation is not understood. Such improved ion beams are expected to enable inexpensive and fast cellular level pathology at even small hospitals to tackle cancer for society’s benefit.Read moreRead less
In-situ biofunctionalisation for additive manufacturing. Additive manufacturing that incorporates printing of live cells can create hierarchical, multi-component structures that mimic biology. However, an ability to include spatially segregated biological cues is currently lacking. This project will develop plasma pen modules to selectively functionalise surfaces and interfaces, as they are being printed, with robustly immobilised hydrogels and biological signalling molecules to direct cell beha ....In-situ biofunctionalisation for additive manufacturing. Additive manufacturing that incorporates printing of live cells can create hierarchical, multi-component structures that mimic biology. However, an ability to include spatially segregated biological cues is currently lacking. This project will develop plasma pen modules to selectively functionalise surfaces and interfaces, as they are being printed, with robustly immobilised hydrogels and biological signalling molecules to direct cell behaviour. The expected outcome is a green technology enabling the fabrication of structures that replicate the native environments of cells in the body to provide optimal efficacy in drug discovery and regenerative medicine, and significant benefits for the Australian biomedical sector.Read moreRead less
Illuminating genomic dark matter to develop new interventions for parasites. This project aims to unravel the molecular basis of parasitism using leading-edge post-genomics approaches. This research expects to explore genomic ‘dark matter’ in the genome to discover how parasites survive and cause disease. The resultant shift in the understanding of molecular mechanisms and processes governing parasitism will lead to new ways of disrupting the intricate parasite-host relationship, which will tran ....Illuminating genomic dark matter to develop new interventions for parasites. This project aims to unravel the molecular basis of parasitism using leading-edge post-genomics approaches. This research expects to explore genomic ‘dark matter’ in the genome to discover how parasites survive and cause disease. The resultant shift in the understanding of molecular mechanisms and processes governing parasitism will lead to new ways of disrupting the intricate parasite-host relationship, which will translate into innovative technologies or products to ameliorate the burden of parasites in livestock animals. Expected socioeconomic benefits include lifting Australia’s scientific knowledge base, reputation in biology and biotechnology, livestock production and investment in translational research.Read moreRead less
Manufacturing diamond membranes for quantum industries. Diamond materials are ideal for quantum technologies and are leading the charge in the new wave of real-world quantum industries. The aim of this project is to develop a reliable source of quantum-active diamond membranes to enable the development of new industries. This would be significant for technologies including quantum telecommunication, medical imaging and nano-scale quantum sensing. Of particular interest, expected outcomes include ....Manufacturing diamond membranes for quantum industries. Diamond materials are ideal for quantum technologies and are leading the charge in the new wave of real-world quantum industries. The aim of this project is to develop a reliable source of quantum-active diamond membranes to enable the development of new industries. This would be significant for technologies including quantum telecommunication, medical imaging and nano-scale quantum sensing. Of particular interest, expected outcomes include the development of materials for advanced medical imaging technologies. Successful development in any of these industries has the potential to greatly benefit society through improved healthcare, the development of new high-tech industries and advanced secure computing. Read moreRead less
A Quantum Matterwave Vortex Gyroscope for Ultrastable Rotation Sensing. This project aims to investigate the basic science underpinning a new rotation sensing technology based on matterwave vortices. Current gyroscopes are susceptible to long-term calibration drifts, which limit their applicability on long timescales where re-calibration is not practical or possible. This project expects to build a matterwave vortex gyroscope and demonstrate that it offers unparalleled long-term stability over ` ....A Quantum Matterwave Vortex Gyroscope for Ultrastable Rotation Sensing. This project aims to investigate the basic science underpinning a new rotation sensing technology based on matterwave vortices. Current gyroscopes are susceptible to long-term calibration drifts, which limit their applicability on long timescales where re-calibration is not practical or possible. This project expects to build a matterwave vortex gyroscope and demonstrate that it offers unparalleled long-term stability over `classical’ gyroscopes based on mechanical and/or optical technology. This could deliver new navigation capabilities, benefitting Australia’s defence forces and nascent space technology industry, as well as enabling slow timescale precision gravimetry for mineral exploration, hydrology, and geology. Read moreRead less
A Memory Powered Engine. Classical heat engines, such as petrol motors, convert thermal energy from hot gases into useful work, but with limited efficiency as much of the thermal energy is lost as waste heat. The project aims to combine experimental techniques in quantum information processing with recent theoretical developments in quantum thermodynamics to demonstrate a proof-of-concept heat engine that converts thermal energy into work with 100% efficiency. A heat engine of this kind would pr ....A Memory Powered Engine. Classical heat engines, such as petrol motors, convert thermal energy from hot gases into useful work, but with limited efficiency as much of the thermal energy is lost as waste heat. The project aims to combine experimental techniques in quantum information processing with recent theoretical developments in quantum thermodynamics to demonstrate a proof-of-concept heat engine that converts thermal energy into work with 100% efficiency. A heat engine of this kind would provide significant benefits to Australia with its potential to revolutionise how we store and use energy. The project will enable Griffith University to continue its pioneering role in developing this technology and to maintain long-term international collaborations.Read moreRead less