Intravital super-resolution imaging via Stimulated Emission Depletion microscopy (STED)-microendoscopy. We will develop a new technology to enable the imaging of sub-cellular structures within a biological specimen, with super-resolution. This intravital super-resolution imaging technology will build off world leading techniques to image objects with super-resolution and to perform this within a specimen, with minimal invasion. The broad ramifications of this technology apply to biology, medical ....Intravital super-resolution imaging via Stimulated Emission Depletion microscopy (STED)-microendoscopy. We will develop a new technology to enable the imaging of sub-cellular structures within a biological specimen, with super-resolution. This intravital super-resolution imaging technology will build off world leading techniques to image objects with super-resolution and to perform this within a specimen, with minimal invasion. The broad ramifications of this technology apply to biology, medical science, imaging and sensing. Important applications include the early detection of debilitating diseases and the advancement of understanding of cellular biology. This research will raise Australia's profile as a world leader in science and technology, building on our emerging presence in the biophysical sciences.Read moreRead less
Coherent X-ray Science and Biophysics. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However, as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This program draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membrane protein ....Coherent X-ray Science and Biophysics. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However, as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This program draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membrane protein. We will develop techniques based on the latest developments in theoretical physics & chemistry, imaging, biology and technology - including the new Australian Synchrotron - to create new approaches to structural biology.Read moreRead less
Diffractive Imaging using Soft X-rays and Electrons. Optical, electron and x-ray microscopy has yielded enormous biological insights and medical benefits to society. Optical microscopy is able to image live tissue, but at relatively low resolution. Electron microscopy can yield high resolution images, but only of highly prepared material. X-ray microscopy yields images of live tissue with a resolution that is intermediate between optical and electron microscopy. This project will provide Austral ....Diffractive Imaging using Soft X-rays and Electrons. Optical, electron and x-ray microscopy has yielded enormous biological insights and medical benefits to society. Optical microscopy is able to image live tissue, but at relatively low resolution. Electron microscopy can yield high resolution images, but only of highly prepared material. X-ray microscopy yields images of live tissue with a resolution that is intermediate between optical and electron microscopy. This project will provide Australian scientists with their first access to x-ray microscopy at its optimum wavelength; and secondly it will provide a superb testbed for x-ray microscopy to be enhanced using unique methods being developed in Australia.Read moreRead less
Optical manipulation of single molecules in nanocontainers and nanotubes. Modern medicine has benefited greatly from technological advances in instrumentation. The ability to probe and manipulate new aspects of biological function often provides unique information that can be used as the basis of new medical treatments. Recent advances in optical instrumentation and biochemical labelling has enabled the study of biological function at the single molecule level. This project proposes to develop n ....Optical manipulation of single molecules in nanocontainers and nanotubes. Modern medicine has benefited greatly from technological advances in instrumentation. The ability to probe and manipulate new aspects of biological function often provides unique information that can be used as the basis of new medical treatments. Recent advances in optical instrumentation and biochemical labelling has enabled the study of biological function at the single molecule level. This project proposes to develop new techniques in single molecule manipulation, to perform studies not easily addressable using current techniques. The proposed research will form the basis of an enabling technology for Australian researchers to make breakthroughs in biomedical research, potentially leading to improvements in healthcare.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989915
Funder
Australian Research Council
Funding Amount
$127,000.00
Summary
X-ray Nano-scale Coherence Facility. Australia is rapidly developing into a world leader for x-ray imaging. This position has been supported by leading research groups and more recently by the development of the Australian Synchrotron. This project will fill a vital missing link in the experimental capability of Australian researchers - a flexible facility that can provide a nanoscale x-ray source. This enhanced capability will lead to new developments in coherent imaging methods. These new meth ....X-ray Nano-scale Coherence Facility. Australia is rapidly developing into a world leader for x-ray imaging. This position has been supported by leading research groups and more recently by the development of the Australian Synchrotron. This project will fill a vital missing link in the experimental capability of Australian researchers - a flexible facility that can provide a nanoscale x-ray source. This enhanced capability will lead to new developments in coherent imaging methods. These new methods will be used in the study of biological systems, leading to better drug design as well as in the study of materials, leading to stronger and lighter components. Read moreRead less
Generalized imaging systems incorporating hybrid hardware-software optics. Fundamental optics research underpins the commercial optical technologies of tomorrow. Modern examples of such evolution, from the fundamental to the commercial, include lasers, LED traffic lights, thin-screen computer monitors and digital cameras. The recent advent of accessible powerful computers, together with recent advances in optical physics, promise a powerful merging of computing and optical technologies into so ....Generalized imaging systems incorporating hybrid hardware-software optics. Fundamental optics research underpins the commercial optical technologies of tomorrow. Modern examples of such evolution, from the fundamental to the commercial, include lasers, LED traffic lights, thin-screen computer monitors and digital cameras. The recent advent of accessible powerful computers, together with recent advances in optical physics, promise a powerful merging of computing and optical technologies into so-called virtual optical systems in which the computer processes optical information in a manner very similar to lenses. In particular, the computer may be used to decode distorted images provided by an imperfect imaging system. Read moreRead less
Nanometric optical sensing for characterisation of microbioreactors. Microfabrication of microfluidic based microbioreactors is a novel technology that is creating advanced tools in the fields of biology and medicine. A critically important step in the development of a microbioreactor is the ability to characterise fluid shear stress of the microenvironment without impacting on the biological system. The development of a microbioreactor in which individual or multiple cells can be cultured and ....Nanometric optical sensing for characterisation of microbioreactors. Microfabrication of microfluidic based microbioreactors is a novel technology that is creating advanced tools in the fields of biology and medicine. A critically important step in the development of a microbioreactor is the ability to characterise fluid shear stress of the microenvironment without impacting on the biological system. The development of a microbioreactor in which individual or multiple cells can be cultured and manipulated will have a significant impact on study of biological systems in cancer research and stem cell research. Read moreRead less
Non-Interferometric Phase Measurement of Exotic Waves. Phase is a key concept in all aspects of physics from biological microscopy through to length measurement and on to industrial inspection. The University of Melbourne has developed a new class of phase measurement techniques that possesses unprecedented flexibility. The aim of this project is to build on the international leadership of the Australian team so as to fully explore and develop these techniques.
Moving-beam phase retrieval - a route to better microscopy! This research will benefit the nation by improving the quality of x-ray diffraction and electron microscopy techniques available to Australian scientists. It will make it possible to examine microscopic structures in more detail and therefore gain more information about the atomic positions in these structures. This will greatly benefit research that depends on finding the structure of very small objects. Such research areas include ....Moving-beam phase retrieval - a route to better microscopy! This research will benefit the nation by improving the quality of x-ray diffraction and electron microscopy techniques available to Australian scientists. It will make it possible to examine microscopic structures in more detail and therefore gain more information about the atomic positions in these structures. This will greatly benefit research that depends on finding the structure of very small objects. Such research areas include nanomaterials, biological engineering, medical science and materials science. The work is also expected to have industrial applications and to make an important contribution to the development of the synchrotron science industry in Australia.Read moreRead less
Scanning Probe Microscopy for Fabrication and Analysis of Polymer Photovoltaics. Australian economic growth will depend increasingly on the provision of devices using materials designed at the molecular level. Scanning probe microscopy, which uses tips placed very close to surfaces to analyse or modify the surfaces with molecular precision, is an indispensible tool in designing such materials. In this project, scanning probe microscopy will be used to analyse and build structures on polymer sola ....Scanning Probe Microscopy for Fabrication and Analysis of Polymer Photovoltaics. Australian economic growth will depend increasingly on the provision of devices using materials designed at the molecular level. Scanning probe microscopy, which uses tips placed very close to surfaces to analyse or modify the surfaces with molecular precision, is an indispensible tool in designing such materials. In this project, scanning probe microscopy will be used to analyse and build structures on polymer solar cells in order to maximise the efficiency of the cells and build prototype nanoscale polymer devices. This will lead to the improvement in devices delivering sustainable energy production - a technology which has the promise of producing energy cheaply from sunlight.Read moreRead less