Advances in Phylogenetic Comparative Methods. An understanding of our biota is impossible without understanding evolution, and developing ways to study it. The outcomes will be useful for biologists conducting theoretically important projects: understanding how and why species have evolved to be the way they are. In addition, the research will be of use to biologists studying more applied questions, such as how to predict whether certain species are likely to become endangered, go extinct, or wh ....Advances in Phylogenetic Comparative Methods. An understanding of our biota is impossible without understanding evolution, and developing ways to study it. The outcomes will be useful for biologists conducting theoretically important projects: understanding how and why species have evolved to be the way they are. In addition, the research will be of use to biologists studying more applied questions, such as how to predict whether certain species are likely to become endangered, go extinct, or whether certain species are likely to become invasive and feral. This research will maintain Australia as a leader in evolutionary biology by cementing strong collaborations with world-leading biologists and statisticians. Read moreRead less
Network structure, connectivity and wildlife disease. Emerging infectious diseases of wildlife pose threats to human health (75% of human emerging diseases are zoonotic). They also threaten biodiversity and livestock. Changes in connectivity between wildlife individuals and populations are occurring because of human activities, including globalisation, climate change and habitat destruction. Understanding how these changes in connectivity affect wildlife disease dynamics is crucial for the deve ....Network structure, connectivity and wildlife disease. Emerging infectious diseases of wildlife pose threats to human health (75% of human emerging diseases are zoonotic). They also threaten biodiversity and livestock. Changes in connectivity between wildlife individuals and populations are occurring because of human activities, including globalisation, climate change and habitat destruction. Understanding how these changes in connectivity affect wildlife disease dynamics is crucial for the development of better strategies to manage their impacts. The project will also build Australia's wider capacity to manage outbreaks of infectious diseases.Read moreRead less
How do past actions and rewards bias goal directed movement? This project aims to identify how different aspects of our past experience affect the accuracy of movements, and study the underlying brain mechanisms. This project will use timing methods and brain recordings to test how the history of movements we have executed in the past, and the rewards associated with those movements, interact to affect subsequent movement execution. The project should advance basic understanding of how the human ....How do past actions and rewards bias goal directed movement? This project aims to identify how different aspects of our past experience affect the accuracy of movements, and study the underlying brain mechanisms. This project will use timing methods and brain recordings to test how the history of movements we have executed in the past, and the rewards associated with those movements, interact to affect subsequent movement execution. The project should advance basic understanding of how the human brain controls movement, and provide theoretical foundations needed to improve the design of human-machine interfaces, and training approaches in industry, rehabilitation and sport.Read moreRead less
Protein structure prediction by deep long-range learning. This project aims to address the challenging problem of protein structure prediction by developing deep long-range learning methods. The project expects to advance protein structure prediction by capturing the long-range interactions through whole sequence learning, rather than short window-based learning. Expected outcomes include next-generation machine-learning techniques for predicting one, two and three-dimensional protein structures ....Protein structure prediction by deep long-range learning. This project aims to address the challenging problem of protein structure prediction by developing deep long-range learning methods. The project expects to advance protein structure prediction by capturing the long-range interactions through whole sequence learning, rather than short window-based learning. Expected outcomes include next-generation machine-learning techniques for predicting one, two and three-dimensional protein structures from their sequences. The expected outcomes should provide significant benefits by computationally determining protein structures beyond homologous sequences, and enabling structure-based drug discovery to disease-causing protein targets previously inaccessible to biotech and pharmaceutical companies.Read moreRead less
Coral Reef Fishes And The Global Decline In Reef Health: Is Biodiversity At Risk Or Resilient? Successful management and protection of marine species depends on understanding the processes that control the biodiversity of marine communities at both local and regional scales. This study will develop a general model to predict the response of reef fish communities to declining habitat structure and diversity across the tropical Pacific Ocean. Using expertise and ecological tools developed in Austr ....Coral Reef Fishes And The Global Decline In Reef Health: Is Biodiversity At Risk Or Resilient? Successful management and protection of marine species depends on understanding the processes that control the biodiversity of marine communities at both local and regional scales. This study will develop a general model to predict the response of reef fish communities to declining habitat structure and diversity across the tropical Pacific Ocean. Using expertise and ecological tools developed in Australia, and in collaboration with scientists working on the other side of the Pacific, this project will develop a broad-scale understanding of the threats to coral reefs and play a leading role in the development of marine-biodiversity management plans for Australia and neighbouring regions.Read moreRead less
How does electrical stimulation affect brain networks? This project aims to generate fundamental knowledge about links between neural mechanisms, electrical brain stimulation and brain function. The project aims to improve knowledge about transcranial direct current stimulation (tDCS) and its effects on complex human brain networks. Such knowledge is necessary to enhance the effectiveness of current stimulation protocols. Using the innovative and interdisciplinary approach, this project will pr ....How does electrical stimulation affect brain networks? This project aims to generate fundamental knowledge about links between neural mechanisms, electrical brain stimulation and brain function. The project aims to improve knowledge about transcranial direct current stimulation (tDCS) and its effects on complex human brain networks. Such knowledge is necessary to enhance the effectiveness of current stimulation protocols. Using the innovative and interdisciplinary approach, this project will provide significant benefits such as crucial mechanistic information about how tDCS modulates healthy brain function which has broad implications for research and clinical use of this technique.Read moreRead less
Alternative Splicing in the Mouse Transcriptome. Although the human genome completion is cause for excitement we do not have any firm indication of precisely how many protein-coding genes exist in a mammalian genome. We have even less indication of the extent to which these genes generate alternative gene products, through a process termed alternative splicing. The detection and sequencing of these full-length alternative gene products is the focus of this application. This application details t ....Alternative Splicing in the Mouse Transcriptome. Although the human genome completion is cause for excitement we do not have any firm indication of precisely how many protein-coding genes exist in a mammalian genome. We have even less indication of the extent to which these genes generate alternative gene products, through a process termed alternative splicing. The detection and sequencing of these full-length alternative gene products is the focus of this application. This application details the opportunity to participate in the identification of the full transcriptome of the mouse and is part of a collaborative effort with The RIKEN Genome Sciences Center in Japan.Read moreRead less
RNA structure prediction by deep learning and evolution-derived restraints. This project addresses the long-standing structure-folding problem of Ribonucleic acids (RNA) whose solution is essential for elucidating the roles of noncoding RNAs in living organisms. The proposed approach will detect hidden homologous sequences and enhance evolutionary covariation signals by developing new algorithms for search and smarter neural networks for deep learning. The project expects to generate new tools ....RNA structure prediction by deep learning and evolution-derived restraints. This project addresses the long-standing structure-folding problem of Ribonucleic acids (RNA) whose solution is essential for elucidating the roles of noncoding RNAs in living organisms. The proposed approach will detect hidden homologous sequences and enhance evolutionary covariation signals by developing new algorithms for search and smarter neural networks for deep learning. The project expects to generate new tools for structure-based probing of RNA evolutional and functional mechanisms. The outcomes should provide significant benefits by high-accuracy computational modelling of RNA structures that are difficult and costly to solve by current structural biology techniques but important for enabling biotech and clinical applications.Read moreRead less
Constructing robust climate proxies to explore human and primate evolution. This project will build the requisite foundation to resolve whether variable climate change sparked the origins of humans and our great ape forebears. Scientists endeavor to recover ancient environmental records to examine this influential idea, but have lacked the means to do so at the scale of a human lifespan. This multidisciplinary effort will harness groundbreaking advances pioneered by our collaborative team to pro ....Constructing robust climate proxies to explore human and primate evolution. This project will build the requisite foundation to resolve whether variable climate change sparked the origins of humans and our great ape forebears. Scientists endeavor to recover ancient environmental records to examine this influential idea, but have lacked the means to do so at the scale of a human lifespan. This multidisciplinary effort will harness groundbreaking advances pioneered by our collaborative team to produce the first fine-scaled climate proxies from the teeth of humans’ closest living relatives. Documenting climate variation across diverse landscapes promises to transform studies of prehistoric ecosystems and past behaviour from omnipresent fossilised teeth, providing further insight into humanity’s unprecedented success.Read moreRead less
SCP/TAPS proteins of the barber’s pole worm. This integrated, collaborative project, will explore, in a targeted way, the structure and function of a key group of molecules in a socio-economically important eukaryotic pathogen and their involvement in pathogen-host interactions. Fundamental knowledge and understanding of these molecules will provide a solid foundation for understanding disease processes and finding new intervention strategies for a range of pathogens. This is crucial, given the ....SCP/TAPS proteins of the barber’s pole worm. This integrated, collaborative project, will explore, in a targeted way, the structure and function of a key group of molecules in a socio-economically important eukaryotic pathogen and their involvement in pathogen-host interactions. Fundamental knowledge and understanding of these molecules will provide a solid foundation for understanding disease processes and finding new intervention strategies for a range of pathogens. This is crucial, given the serious drug resistance problems in pathogens, and residue problems in meat, milk and the environment.Read moreRead less