Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitri ....Structure and activity of host-defence peptides from Australian anurans: anticancer agents, neuropeptides and nNOS inhibitors. We have discovered peptides that may have clinical applications. This is significant as these molecules may have one or more of the following properties. They may have anti-cancer effects; they may increase the effectiveness of the immune system by enhancing lymphocyte formation; and, they may act to reduce inflammation, stroke or cardiac conditions by controlling nitric oxide formation. Another national benefit is that personnel involved in this project are trained to the highest international standards in peptide chemistry/mass spectrometry/nuclear magnetic resonance: currently, there are not enough trained scientists in this area to meet demand.Read moreRead less
Biologically active peptides and proteins from anurans: the relationship between structure and activity. We have identified peptides (from glands of frogs and toads), some of which are amongst the most powerful biologically active compounds in the animal kingdom. The aims of this project are to investigate the relationship between the structure and bioactivity of chosen groups of peptides including pheromones, anticancer and antibiotic peptides, and peptides which inhibit neuronal nitric oxide ....Biologically active peptides and proteins from anurans: the relationship between structure and activity. We have identified peptides (from glands of frogs and toads), some of which are amongst the most powerful biologically active compounds in the animal kingdom. The aims of this project are to investigate the relationship between the structure and bioactivity of chosen groups of peptides including pheromones, anticancer and antibiotic peptides, and peptides which inhibit neuronal nitric oxide synthase. It would be of national benefit if any of these peptides have applied application, e.g. if we can use the sex pheromone of the cane toad to reduce its population, or if we can produce an anticancer active peptide of clinical applicability.Read moreRead less
ARC Molecular and Materials Structure Research Network. The Network will build powerful e-Science resources for the structural sciences. Collaborative remote access will be developed for sophisticated instrumentation, including instruments planned for the Replacement Research Reactor and Australian Synchrotron. A structure database service with cross disciplinary content and versatile visualisation and analysis capabilities will further exemplify smart information use. The internet services will ....ARC Molecular and Materials Structure Research Network. The Network will build powerful e-Science resources for the structural sciences. Collaborative remote access will be developed for sophisticated instrumentation, including instruments planned for the Replacement Research Reactor and Australian Synchrotron. A structure database service with cross disciplinary content and versatile visualisation and analysis capabilities will further exemplify smart information use. The internet services will ultimately harness the Grid, enabling linkage into other national and international Grid systems. Encompassing physics, computer science, applied mathematics, chemistry and biochemistry, and catalysing interaction across these disciplines, the MMSN will impact all five National Research Priority 3 goals.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989759
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Australian Access to and Operation of Advanced Synchrotron Radiation Facilities at the Photon Factory. The primary national benefit of this application will be continued access by peer review for Australian scientists to the advanced synchrotron-radiation capabilities of the Australian National Beamline Facility and other complementary beamlines at the Photon Factory, Japan. This proposal is consistent with the National Research Priorities of An Environmentally Sustainable Australia, Promoting a ....Australian Access to and Operation of Advanced Synchrotron Radiation Facilities at the Photon Factory. The primary national benefit of this application will be continued access by peer review for Australian scientists to the advanced synchrotron-radiation capabilities of the Australian National Beamline Facility and other complementary beamlines at the Photon Factory, Japan. This proposal is consistent with the National Research Priorities of An Environmentally Sustainable Australia, Promoting and Maintaining Good Health and Frontier Technologies for Building and Transforming Australian Industries and will generate science to support and stimulate domestic industry, enhance the domestic knowledge base and international research profile, train students and future synchrotron scientists and foster domestic and international collaborations.Read moreRead less
ARC Research Network for a Secure Australia. The Research Network for a Secure Australia (RNSA) is a multi-disciplinary collaboration established to strengthen Australia's research capacity for protecting critical infrastructure from natural or human-caused disasters including terrorist acts. The RNSA will facilitate a knowledge-sharing network for research organisations, government and the private sector to develop research tools and methods to mitigate emerging safety and security issues relat ....ARC Research Network for a Secure Australia. The Research Network for a Secure Australia (RNSA) is a multi-disciplinary collaboration established to strengthen Australia's research capacity for protecting critical infrastructure from natural or human-caused disasters including terrorist acts. The RNSA will facilitate a knowledge-sharing network for research organisations, government and the private sector to develop research tools and methods to mitigate emerging safety and security issues relating to critical infrastructure. World-leaders with extensive national and international linkages in relevant scientific, engineering and technological research will lead this collaboration. The RNSA will launch various activities to foster research collaboration and nurture young investigators.Read moreRead less
Special Research Initiatives - Grant ID: SR0354781
Funder
Australian Research Council
Funding Amount
$40,000.00
Summary
Research Network for Engineering a Secure Australia (RNESA). The Research Network for Engineering a Secure Australia (RNESA) is a multi-disciplinary collaboration established to strengthen Australia's science and technology capacity for protecting the Nation's critical infrastructure from natural or human-caused disasters. RNESA will facilitate a knowledge sharing network for government, universities and the private sector to produce innovative engineering solutions to the emerging security prob ....Research Network for Engineering a Secure Australia (RNESA). The Research Network for Engineering a Secure Australia (RNESA) is a multi-disciplinary collaboration established to strengthen Australia's science and technology capacity for protecting the Nation's critical infrastructure from natural or human-caused disasters. RNESA will facilitate a knowledge sharing network for government, universities and the private sector to produce innovative engineering solutions to the emerging security problems relating to the safety of critical infrastructure. This initiative will draw together researchers across disciplines to identify a roadmap for future R&D in this area. RNESA's final outcomes will lead to multi-hazard mitigation strategies and a real-time crisis support network to enable the nation to manage potential disasters.Read moreRead less