Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347962
Funder
Australian Research Council
Funding Amount
$218,000.00
Summary
Adelaide Mass Spectrometry and Analysis Facility. This joint proposal by two South Australian universities and the Hanson Institute seeks to establish a facility for rapid characterisation and identification of biomolecules by means of MALDI-TOF and Nano LC mass spectrometry. The requested equipment is not available in South Australia. This proposal would establish a Nano LC (Q-TOF) node at the University of Adelaide-University of South Australia location and a MALDI-TOF node at the Flinders loc ....Adelaide Mass Spectrometry and Analysis Facility. This joint proposal by two South Australian universities and the Hanson Institute seeks to establish a facility for rapid characterisation and identification of biomolecules by means of MALDI-TOF and Nano LC mass spectrometry. The requested equipment is not available in South Australia. This proposal would establish a Nano LC (Q-TOF) node at the University of Adelaide-University of South Australia location and a MALDI-TOF node at the Flinders location. Its presence would greatly enhance the quality of research and teaching in priority areas such as proteomics, bioinformatics and nanotechnology and would provide a basis for fostering university and biotechnology industry collaborations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0239035
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
Regional facility for surface and micro-structure analysis. Adelaide, Flinders and SA Universities seek to enhance the regional facility for surface and microstructure analysis. Equipment includes electron back scatter pattern imaging, high resolution coater, microprobe (CAMECA SX51) upgrade and X ray microtomography to be located at Adelaide University Centre for Electron Microscopy and Microstructure Analysis, the hub of the regional facility. The University of South Australia Ian Wark Researc ....Regional facility for surface and micro-structure analysis. Adelaide, Flinders and SA Universities seek to enhance the regional facility for surface and microstructure analysis. Equipment includes electron back scatter pattern imaging, high resolution coater, microprobe (CAMECA SX51) upgrade and X ray microtomography to be located at Adelaide University Centre for Electron Microscopy and Microstructure Analysis, the hub of the regional facility. The University of South Australia Ian Wark Research Institute node will house ToF-SIMS and SAM upgrades, the Flinders node a multimode STM atomic force microscope, and the Adelaide University Waite Campus node confocal xyz control and digital camera. Applications include biological, materials and geological research projects.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453973
Funder
Australian Research Council
Funding Amount
$696,093.00
Summary
Surface Spectroscopic and Microstructure Analysis. Funding is requested for an X-ray Photoelectron Spectrometer (XPS) and an Image Plate Guinier Camera (IPGC), to update and expand capabilities in surface spectroscopic and microstructural analysis of a wide range of materials. The XPS unit, to be located at the University of SA, will replace two 18-year old XPS units at UniSA and Flinders University. The IPGC is a new and unique instrument which will be located at the University of Adelaide. The ....Surface Spectroscopic and Microstructure Analysis. Funding is requested for an X-ray Photoelectron Spectrometer (XPS) and an Image Plate Guinier Camera (IPGC), to update and expand capabilities in surface spectroscopic and microstructural analysis of a wide range of materials. The XPS unit, to be located at the University of SA, will replace two 18-year old XPS units at UniSA and Flinders University. The IPGC is a new and unique instrument which will be located at the University of Adelaide. These items will be incorporated into the SA Regional Facility, which provides seamless access to instrumentation across nodes. Applications include materials science, geological and biological research projects.Read moreRead less
Designing microarray experiments. Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, pharmaceutical and agricultural sciences. There are many sources of uncertainty in microarray experimentation and good statistical designs are essential for ensuring that the effects of interest to scientists are accurately and precisely measured. This Pr ....Designing microarray experiments. Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, pharmaceutical and agricultural sciences. There are many sources of uncertainty in microarray experimentation and good statistical designs are essential for ensuring that the effects of interest to scientists are accurately and precisely measured. This Project will develop novel designs for microarray experiments and focus on the advancement of topics crucial to Australia's success in technological research.
Read moreRead less
Targeted analysis of the arbuscular mycorrhizal symbiosis phenome in a model host, tomato. We will capitalise on our previous discovery of novel phenotypic variation in arbuscular mycorrhizas in mutant and wild-type tomato, to explore development and function of the symbiosis at the molecular-genetic level. We will clone and sequence the gene responsible for mycorrhiza-defective phenotypes to provide inferences on function and relations with other genes. We will determine if plant defence blocks ....Targeted analysis of the arbuscular mycorrhizal symbiosis phenome in a model host, tomato. We will capitalise on our previous discovery of novel phenotypic variation in arbuscular mycorrhizas in mutant and wild-type tomato, to explore development and function of the symbiosis at the molecular-genetic level. We will clone and sequence the gene responsible for mycorrhiza-defective phenotypes to provide inferences on function and relations with other genes. We will determine if plant defence blocks fungal colonisation in the mutant and/or varies with different wild-type phenotypes and explore molecular mechanisms of nutrient transfer from fungus to plant in relation to phenotypic diversity. The project will provide new insights into genome/phenome interactions controlling this widespread beneficial symbiosis.Read moreRead less
Wireless microvalve for biomedical applications. This program will investigate and perform an in-laboratory proof-of-concept demonstration of a polymer microvalve that can operate by a remote control radio signal. This will be a wireless microvalve that does not require a battery power source. This advance in the technology and scientific knowledge will have important applications for humankind ranging from drug delivery devices to through to valves in chips that can perform microfluidic chemica ....Wireless microvalve for biomedical applications. This program will investigate and perform an in-laboratory proof-of-concept demonstration of a polymer microvalve that can operate by a remote control radio signal. This will be a wireless microvalve that does not require a battery power source. This advance in the technology and scientific knowledge will have important applications for humankind ranging from drug delivery devices to through to valves in chips that can perform microfluidic chemical analysis. A far reaching long-range vision is its use in electronically reversible male fertility control. The community benefit in terms of novel biomedical devices and the resulting large international commercial market is significant.Read moreRead less
Afferent stimulation-induced plasticity and its functional significance. Certain regions of the brain can reorganise (plasticity) during motor learning or when there is damage to peripheral nerves or muscles. There is a large body of evidence for these plastic changes in animals. Until recently data showing that similar changes occurred in humans was limited. However, we have recently demonstrated that certain patterns of peripheral stimulation can indeed induce similar changes in human subjects ....Afferent stimulation-induced plasticity and its functional significance. Certain regions of the brain can reorganise (plasticity) during motor learning or when there is damage to peripheral nerves or muscles. There is a large body of evidence for these plastic changes in animals. Until recently data showing that similar changes occurred in humans was limited. However, we have recently demonstrated that certain patterns of peripheral stimulation can indeed induce similar changes in human subjects. These findings are important for our understanding of the mechanisms of motor control and learning.Read moreRead less
Mathematical and mechanical models in nano-engineering and nanomedicine. The major environmental problems generated from global warming and the major human health problems, like cancer and diabetes, if they are to be solved at all, will most likely be resolved making use of advances in nanobiotechnology. This proposal will position Australia as a leader in the modelling of nanodevices such as gigahertz oscillators, nano-electromagnets, nanosensors, nanosyringes and nanoporous media suitable for ....Mathematical and mechanical models in nano-engineering and nanomedicine. The major environmental problems generated from global warming and the major human health problems, like cancer and diabetes, if they are to be solved at all, will most likely be resolved making use of advances in nanobiotechnology. This proposal will position Australia as a leader in the modelling of nanodevices such as gigahertz oscillators, nano-electromagnets, nanosensors, nanosyringes and nanoporous media suitable for hydrogen storage and gas separation, which will lead to new technologies and commercial spin-offs that will be of major benefit to this country. The applicants will develop a range of topics in nano-engineering and nanomedicine, training a team that will provide the next generation of researchers in these vital areas.Read moreRead less
Foundations for a Cognitive Biology. Understanding cognition has important implications for individual and social wellbeing and thus for the nation's economic health. Until the many disciplines concerned with cognition can effectively integrate their disparate findings, public investment in cognitive research will not yield benefits to its potential. The project aims to produce a coherent model of cognition that will facilitate new cross-disciplinary approaches to research, thereby improving Aus ....Foundations for a Cognitive Biology. Understanding cognition has important implications for individual and social wellbeing and thus for the nation's economic health. Until the many disciplines concerned with cognition can effectively integrate their disparate findings, public investment in cognitive research will not yield benefits to its potential. The project aims to produce a coherent model of cognition that will facilitate new cross-disciplinary approaches to research, thereby improving Australia's means of promoting and maintaining healthy cognitive function and treating cognitive dysfunction.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100078
Funder
Australian Research Council
Funding Amount
$190,000.00
Summary
An advanced multimodal terahertz spectroscopy and imaging system for WA. An advanced multimodal terahertz spectroscopy and imaging system: Terahertz (THz) technology is in use in diverse applications from semiconductor inspection, metamaterials, biology and protein analysis, pharmaceutical sciences and formulations; security and surveillance, and biomedical imaging for burn assessment and cancer detection. This project will provide researchers with access to state-of-the-art THz spectroscopy and ....An advanced multimodal terahertz spectroscopy and imaging system for WA. An advanced multimodal terahertz spectroscopy and imaging system: Terahertz (THz) technology is in use in diverse applications from semiconductor inspection, metamaterials, biology and protein analysis, pharmaceutical sciences and formulations; security and surveillance, and biomedical imaging for burn assessment and cancer detection. This project will provide researchers with access to state-of-the-art THz spectroscopy and imaging facilities, resulting in high-impact outcomes across the physical and biological sciences and engineering, broadly contributing to Australia's economic and social well being.Read moreRead less