Multivariate Algorithmics: Meeting the Challenge of Real World computational complexity. This Project will result in better methods for designing the algorithms that all computer applications depend on. Algorithms are the instruction sets that tell computers how to process information. Some information processing tasks are intrinsically difficult, even for computers working at enormous speeds. This Project will deliver new mathematical approaches to overcome these difficulties. More efficient al ....Multivariate Algorithmics: Meeting the Challenge of Real World computational complexity. This Project will result in better methods for designing the algorithms that all computer applications depend on. Algorithms are the instruction sets that tell computers how to process information. Some information processing tasks are intrinsically difficult, even for computers working at enormous speeds. This Project will deliver new mathematical approaches to overcome these difficulties. More efficient algorithmic approaches for difficult problems enable advances in all areas of computer applications such as medical diagnosis and health prediction, national security, communications efficiency, industrial productivity and all fields of science and engineering.Read moreRead less
Local reoptimization for turbocharging heuristics. Theoretical computer science has up until now had little impact on the design of effective heuristics. While data sets may be large, significant structure is almost always present and important to take into account when designing algorithms. Parameterised complexity considers the underlying structure by parameterising not only on the size of the input but also on structural parameters. This project aims to take advantage of the many opportunitie ....Local reoptimization for turbocharging heuristics. Theoretical computer science has up until now had little impact on the design of effective heuristics. While data sets may be large, significant structure is almost always present and important to take into account when designing algorithms. Parameterised complexity considers the underlying structure by parameterising not only on the size of the input but also on structural parameters. This project aims to take advantage of the many opportunities for new theories in the design of new heuristics and in turbocharging existing heuristics for computationally hard problems.Read moreRead less
Skin Microbes and Animal Health: Understanding the Ecological Context. This project aims to understand the fundamental ecological relationships between animal hosts (frogs, geckos) and bacteria on their skin by separating host effects from environmental factors that determine skin microbiome composition. The research is significant because it will generate new knowledge needed to understand how skin microbes function in providing protection against disease. Expected outcomes include the provisio ....Skin Microbes and Animal Health: Understanding the Ecological Context. This project aims to understand the fundamental ecological relationships between animal hosts (frogs, geckos) and bacteria on their skin by separating host effects from environmental factors that determine skin microbiome composition. The research is significant because it will generate new knowledge needed to understand how skin microbes function in providing protection against disease. Expected outcomes include the provision of essential information that will guide future research efforts on the factors that determine a healthy skin microbial community (which is needed before skin diseases can be combated). The research will provide significant benefits, including more targeted conservation efforts to combat wildlife skin diseases.Read moreRead less
Competition between regulatory processes in Amphibians: Testing the effects of physical and physiological factors on thermoregulation and hydroregulation. Regulation of body temperature is important for many animals, and it influences processes such as growth and reproduction. However, it is not clear to what extent wet-skinned animals can control body temperature because of evaporation. Understanding this about frogs is crucial to understanding their habitat requirements and the effects of clim ....Competition between regulatory processes in Amphibians: Testing the effects of physical and physiological factors on thermoregulation and hydroregulation. Regulation of body temperature is important for many animals, and it influences processes such as growth and reproduction. However, it is not clear to what extent wet-skinned animals can control body temperature because of evaporation. Understanding this about frogs is crucial to understanding their habitat requirements and the effects of climate change, habitat modification, and the invasion of cane toads on their populations. Amphibians are in decline worldwide, and research into the basic ways that these animals interact with the physical environment is needed before effective management plans can be produced. The unique physiological characteristics of Australian frogs make this is the best place in the world to do this research.Read moreRead less
Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying ....Next generation high throughput lipidomics using adaptive modelling. This project aims to develop a unique high-throughput method to capture the lipidomic profile of human plasma suitable for large human population screening. Lipids are fundamental to every biological system, but our understanding of their regulation in humans have been largely superficial. By incorporating a new lipidomics approach, with genomic data, this project aims to expand our understanding of human biology by identifying regulators of lipid metabolism. The large diversity in humans necessitate sufficient sample sizes to identify true genetic regulators, but to date techniques capturing phenotypic data (lipids) have been largely limited. It is anticipated that this study will identify new regulators of lipid metabolism in humans.Read moreRead less
How does habitat complexity drive motor ageing and fitness in wild mammals? This project aims to demonstrate how habitat complexity shapes motor ageing in wild dasyurid marsupials, and to improve these animals’ motor function, slow its decline and increase reproductive output via behavioural and physiological changes. Motor decline should dramatically impact an animal growth, survival and reproduction by affecting how it moves through habitats when foraging, seeking mates, or escaping from preda ....How does habitat complexity drive motor ageing and fitness in wild mammals? This project aims to demonstrate how habitat complexity shapes motor ageing in wild dasyurid marsupials, and to improve these animals’ motor function, slow its decline and increase reproductive output via behavioural and physiological changes. Motor decline should dramatically impact an animal growth, survival and reproduction by affecting how it moves through habitats when foraging, seeking mates, or escaping from predators. However, little is known about the environmental drivers of motor ageing in wild animals. Our project addresses an important gap in the field of evolutionary ecology. Since decline in muscle function affects the quality of Australian's life, our work could lead to important economic and health implications.Read moreRead less
Do frogs hydroregulate? Regulation versus tolerance of thermal and hydric states. Amphibians are in decline in Australia and worldwide. Frogs are a middle link in terrestrial and aquatic food chains (as predators and prey) so are important for the sustainability of Australia's biodiversity and as indicators of environmental problems. Basic research about the ways Australian frogs interact with the physical environment to balance body water and temperature is crucial to predicting the effects of ....Do frogs hydroregulate? Regulation versus tolerance of thermal and hydric states. Amphibians are in decline in Australia and worldwide. Frogs are a middle link in terrestrial and aquatic food chains (as predators and prey) so are important for the sustainability of Australia's biodiversity and as indicators of environmental problems. Basic research about the ways Australian frogs interact with the physical environment to balance body water and temperature is crucial to predicting the effects of climate change or habitat modification on frogs. This basic information is needed to produce effective conservation plans for native frogs and management plans for invasive cane toads. We will train students in techniques and concepts in ecology, conservation biology, and animal physiology.Read moreRead less
Density regulation as a major determinant of population persistence: advancing empirical and theoretical approaches to conserve biodiversity. Without efficient application of limited conservation resources, more species will go extinct and invasive species will continue to proliferate. With a better understanding of extinction processes, a higher benefit:cost ratio will ensure better outcomes for biodiversity. We will directly address (1) the sustainable use of Australia's biodiversity by provid ....Density regulation as a major determinant of population persistence: advancing empirical and theoretical approaches to conserve biodiversity. Without efficient application of limited conservation resources, more species will go extinct and invasive species will continue to proliferate. With a better understanding of extinction processes, a higher benefit:cost ratio will ensure better outcomes for biodiversity. We will directly address (1) the sustainable use of Australia's biodiversity by providing evidence-based support for minimum viable population size targets to avoid extinction; (2) responding to climate change by determining the species- and environmentally specific contexts leading to elevated risks of extinction; and (3) protecting Australia from invasive diseases and pests by determining density targets that maximise eradication success.Read moreRead less
Linking terrestrial–aquatic fluxes to rectify the Australian carbon balance. This project aims to rectify the Australian carbon balance by determining the amount of terrestrial carbon that is lost to streams and rivers across the country. Through a novel integration of high-resolution hydrochemical and gas measurements, remote sensing and machine learning algorithms, the project intends to generate new knowledge about the links between terrestrial carbon sequestration and aquatic carbon export. ....Linking terrestrial–aquatic fluxes to rectify the Australian carbon balance. This project aims to rectify the Australian carbon balance by determining the amount of terrestrial carbon that is lost to streams and rivers across the country. Through a novel integration of high-resolution hydrochemical and gas measurements, remote sensing and machine learning algorithms, the project intends to generate new knowledge about the links between terrestrial carbon sequestration and aquatic carbon export. Expected outcomes include a refined estimate of the net carbon sequestration potential across Australian biomes and seasons. This should provide significant benefits such as avoiding misalignment of greenhouse gas abatement policies and advancing carbon cycling models and predictions.Read moreRead less
Do marine heat waves cause pathogen outbreaks in Australian coastal waters? This project aims to identify links between increasingly frequent Marine Heat Wave (MHW) events and outbreaks of microbes that cause disease in marine animals, reduced aquaculture yields and human health hazards. Pathogenic bacteria from the Vibrio genus exhibit a preference for elevated seawater temperature and this project will test the hypothesis that episodic MHWs will trigger blooms of dangerous species. Using innov ....Do marine heat waves cause pathogen outbreaks in Australian coastal waters? This project aims to identify links between increasingly frequent Marine Heat Wave (MHW) events and outbreaks of microbes that cause disease in marine animals, reduced aquaculture yields and human health hazards. Pathogenic bacteria from the Vibrio genus exhibit a preference for elevated seawater temperature and this project will test the hypothesis that episodic MHWs will trigger blooms of dangerous species. Using innovative ecogenomic tools, this project will track the impact of MHWs on the dynamics of pathogenic Vibrio within coastal habitats, oyster farming facilities and coral reefs. The benefit of this project will be essential new knowledge on an emerging threat to Australia’s valuable marine estate, food security and public health.Read moreRead less