A new platform for poled glass waveguides in the mid-infrared. Mid-infrared light (beyond red out to what we feel as radiant heat) underpins many crucial applications that include the remote detection of explosives, chemicals and biological agents; dramatically speeding up internet communications; and even helping us detect planets in distant solar systems. The enormous cost of generating and analysing mid-infrared light using current technology has prevented many of these life-changing applicat ....A new platform for poled glass waveguides in the mid-infrared. Mid-infrared light (beyond red out to what we feel as radiant heat) underpins many crucial applications that include the remote detection of explosives, chemicals and biological agents; dramatically speeding up internet communications; and even helping us detect planets in distant solar systems. The enormous cost of generating and analysing mid-infrared light using current technology has prevented many of these life-changing applications coming to fruition. This project aims to change this and deliver technological leadership in this crucial field to Australia, thereby generating significant social and economic benefits. This project will also enhance Australia's international links and build on a range of national research programs.Read moreRead less
Effective and accurate model dynamics, deterministic and stochastic, across multiple space and time scales. A persistent feature of complex systems in engineering and science is the emergence of macroscopic, coarse grained, coherent behaviour from the interactions of microscopic agents (molecules, cells, grains) and with their environment. In current modeling, ranging from ecology to materials science, the underlying microscopic mechanisms are often known, but the closures to translate microscal ....Effective and accurate model dynamics, deterministic and stochastic, across multiple space and time scales. A persistent feature of complex systems in engineering and science is the emergence of macroscopic, coarse grained, coherent behaviour from the interactions of microscopic agents (molecules, cells, grains) and with their environment. In current modeling, ranging from ecology to materials science, the underlying microscopic mechanisms are often known, but the closures to translate microscale knowledge to a system level macroscopic description are rarely available in closed form. Our novel methodology will explore this stumbling block, and promises to radically change the modeling, exploration and understanding of multiscale complex system behaviour.Read moreRead less
Study of mathematical models of evolution using the theory of quantum games - strengthening the theoretical foundation of quantum computation. The fields of nanotechnology, quantum technology and quantum information processing are rapidly converging. This project aims to provide a novel approach in the fundamental understanding of quantum computation/information by using methods inspired by mathematics of evolutionary competition. The project will contribute towards the theoretical foundations o ....Study of mathematical models of evolution using the theory of quantum games - strengthening the theoretical foundation of quantum computation. The fields of nanotechnology, quantum technology and quantum information processing are rapidly converging. This project aims to provide a novel approach in the fundamental understanding of quantum computation/information by using methods inspired by mathematics of evolutionary competition. The project will contribute towards the theoretical foundations of quantum computation by complementing efforts of several groups in Australia collaborating on the experimental design of quantum computers. The outcome of this project will contribute towards the successful operation of quantum computers and will help maintain Australia's position in the global forefront of quantum computation/information.
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Modelling of multiscale systems in engineering and science supports large-scale equation-free simulations and analysis. A persistent feature of complex systems in engineering and science is the emergence of macroscopic, coarse grained, coherent behaviour from the interactions of microscopic agents (molecules, cells) and with their environment. In current modeling, ranging from ecology to materials science, the underlying microscopic mechanisms are known, but the closures to translate microscale ....Modelling of multiscale systems in engineering and science supports large-scale equation-free simulations and analysis. A persistent feature of complex systems in engineering and science is the emergence of macroscopic, coarse grained, coherent behaviour from the interactions of microscopic agents (molecules, cells) and with their environment. In current modeling, ranging from ecology to materials science, the underlying microscopic mechanisms are known, but the closures to translate microscale knowledge to a system level macroscopic description are rarely available in closed form. Our novel, equation free, computational methodologies will circumvent this stumbling block, and promises to radically change the modeling, exploration and understanding of complex system behavior. We continue to develop this powerful computational methodology. Read moreRead less
Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions. Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpi ....Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions. Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpin the rational design of drugs for the treatment of a range of human health conditions. This project will also provide training of young researchers to the highest international standards in mass spectrometry and protein science, for benefit to Australian industry and research.Read moreRead less
Communication and information storage mechanisms in complex dynamical brain networks. Recordings of electrical activity in the brain often cycle repetitively. The aim of this research is to explain how these brain rhythms assist the brain to coordinate simultaneous activity in several regions. Australian socioeconomic benefits include: (i) contributions to the knowledge base of theoretical neuroscience, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of internation ....Communication and information storage mechanisms in complex dynamical brain networks. Recordings of electrical activity in the brain often cycle repetitively. The aim of this research is to explain how these brain rhythms assist the brain to coordinate simultaneous activity in several regions. Australian socioeconomic benefits include: (i) contributions to the knowledge base of theoretical neuroscience, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of international collaborations with Europe and Japan; (iii) outcomes will ultimately impact on improved medical bionics and future interfaces between brain activity and machines or computers; and (iv) commercialization and technology transfer opportunities, via the transfer of results to biologically inspired engineering.Read moreRead less
Negative ion mass spectrometry: fundamental studies and applied applications. We seek to:
(i) establish negative ion mass spectrometry as an analytical tool for the sequencing of proteins and to probe the structures of active peptide Ca2+ calmodulin complexes which, for example, inhibit the formation of NO from nitric oxide synthases. Controlling the concentration of nitric oxide may assist with the treatment of inflammatory and cardiac diseases, stroke and diseases of the central nervous syst ....Negative ion mass spectrometry: fundamental studies and applied applications. We seek to:
(i) establish negative ion mass spectrometry as an analytical tool for the sequencing of proteins and to probe the structures of active peptide Ca2+ calmodulin complexes which, for example, inhibit the formation of NO from nitric oxide synthases. Controlling the concentration of nitric oxide may assist with the treatment of inflammatory and cardiac diseases, stroke and diseases of the central nervous system.
(ii) to study the possibility of the formation of biological molecules of life in interstellar regions
(iii) to train graduate students to international standards in the chemistry of proteomics.Read moreRead less
Fibre sensors with subwavelength features in the Terahertz radiation (T-ray) regime. With this program, Australia will benefit from expertise in photonics that will develop new chemical biosensors based on optical fibre technology. The novelty is that the fibres will be used to guide Terahertz radiation (T-ray) frequencies that will be able to detect very small samples of material or fluid. This is a fundamental step towards a system that will impact on applications in the medical, pharmaceutica ....Fibre sensors with subwavelength features in the Terahertz radiation (T-ray) regime. With this program, Australia will benefit from expertise in photonics that will develop new chemical biosensors based on optical fibre technology. The novelty is that the fibres will be used to guide Terahertz radiation (T-ray) frequencies that will be able to detect very small samples of material or fluid. This is a fundamental step towards a system that will impact on applications in the medical, pharmaceutical, forensic, and security industries. Ultimately, Australia will benefit from a new cutting-edge technology and a new diagnostic biosensing technique.Read moreRead less
Advanced studies of QCD and the strong interaction. This project will significantly advance our knowledge of the subatomic structure of the universe. It will maintain excellence and strength in an area where Australia has built an outstanding international reputation over the past decade. It will place Australia at the cutting edge of fundamental and computational science research and it will maintain and grow strong international links. It will produce Australian graduates and research associa ....Advanced studies of QCD and the strong interaction. This project will significantly advance our knowledge of the subatomic structure of the universe. It will maintain excellence and strength in an area where Australia has built an outstanding international reputation over the past decade. It will place Australia at the cutting edge of fundamental and computational science research and it will maintain and grow strong international links. It will produce Australian graduates and research associates of high quality, who will benefit from participating in these state-of-the-art studies and from the advanced training in modelling, high-performance computer simulation and visualisation. This training will have major economic benefits for and provide strong links to Australian industry.Read moreRead less
The Essence of QCD Vacuum Structure. This first-principles study of quantum field theory will elucidate an outstanding mystery of modern particle physics. Understanding confinement is recognized as one of the top 10 Physics Questions to Ponder for a Millennium or Two. In support of the National Research Priorities, new scientific data visualization techniques will be transferred to industry, facilitating smart information use. Further economic benefits are realized through the training and devel ....The Essence of QCD Vacuum Structure. This first-principles study of quantum field theory will elucidate an outstanding mystery of modern particle physics. Understanding confinement is recognized as one of the top 10 Physics Questions to Ponder for a Millennium or Two. In support of the National Research Priorities, new scientific data visualization techniques will be transferred to industry, facilitating smart information use. Further economic benefits are realized through the training and development of expertise in high-performance parallel computing, promoting an innovation culture and economy. The opportunity for young Australian Honours and Postgraduate students to work at the forefront of nuclear and particle theory is an obvious social benefit.
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