ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reac ....ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reactions and how higher brain function emerges from networks of neurons. By building a diverse, multidisciplinary, and industry-engaged ecosystem, the Centre means to develop our future leaders at the interface of quantum science and biology and drive Australian innovation across manufacturing, energy, agriculture, health, and national security.Read moreRead less
ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. The ARC Centre for the Mathematical Analysis of Cellular Systems aims to deliver the mathematics required to compute life. The Centre will deliver innovation in computational and mathematical biology and establish in silico biology alongside in vivo and in vitro biology. These models will allow us to understand the complexity of life at the cellu ....ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. ARC Centre of Excellence for the Mathematical Analysis of Cellular Systems. The ARC Centre for the Mathematical Analysis of Cellular Systems aims to deliver the mathematics required to compute life. The Centre will deliver innovation in computational and mathematical biology and establish in silico biology alongside in vivo and in vitro biology. These models will allow us to understand the complexity of life at the cellular level and enable new ways of combining diverse and heterogenous data. This will allow us to understand the mechanisms underlying cellular behaviour, and to apply rational design engineering methods in order to control the dynamics of biological systems. Read moreRead less
Uncovering the molecular mechanisms of potassium channel activity. The aim of this project is to determine the mechanisms of protein-mediated potassium ion transport across cell membranes. It will combine advanced simulations, structural biology and electrophysiology to describe the detailed molecular processes underscoring calcium-activated potassium channel conduction, gating and inactivation. The expected outcome is an improved description of how ion channels recognise and respond to physiolo ....Uncovering the molecular mechanisms of potassium channel activity. The aim of this project is to determine the mechanisms of protein-mediated potassium ion transport across cell membranes. It will combine advanced simulations, structural biology and electrophysiology to describe the detailed molecular processes underscoring calcium-activated potassium channel conduction, gating and inactivation. The expected outcome is an improved description of how ion channels recognise and respond to physiological stimuli to control electrical signalling the body. Our results will provide benefits in the form of basic understanding relevant to ion transport phenomena in biological systems, and atomic-level views of nervous system function to guide future directions in pharmacology.Read moreRead less
Comparing properties of innate immune proteins of bats and humans. Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the “supra-immunity” of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms t ....Comparing properties of innate immune proteins of bats and humans. Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the “supra-immunity” of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms that regulate the signalosomes. The intended outcome is to answer the long-standing question of control of speed and amplitude of innate immune response at the molecular level. Both locally and internationally, this new approach should provide benefits across structural biology, molecular evolution and biotechnology.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100036
Funder
Australian Research Council
Funding Amount
$4,999,600.00
Summary
ARC Training Centre for Radiation Innovation. This Centre aims to train the next generation of transdisciplinary leaders to enable, grow and transform industries that utilise or are impacted by radiation. Rapid growth in the natural resources, health, space and national security sectors urgently requires a highly capable workforce with scientific and regulatory knowledge to develop new technologies and social licence needs to maximise benefits. Outcomes include new methods of radiopharmaceutical ....ARC Training Centre for Radiation Innovation. This Centre aims to train the next generation of transdisciplinary leaders to enable, grow and transform industries that utilise or are impacted by radiation. Rapid growth in the natural resources, health, space and national security sectors urgently requires a highly capable workforce with scientific and regulatory knowledge to develop new technologies and social licence needs to maximise benefits. Outcomes include new methods of radiopharmaceutical production, more resilient spacecraft and robust regulatory frameworks. Industries and communities will benefit from a future workforce prepared for safe adoption, development and delivery of emerging techniques and advanced radiation technologies, enhancing Australia’s prosperity and security.Read moreRead less
A Space-Based Quantum Communications Platform using Continuous Variables. This work proposes to investigate a new space-borne platform capable of quantum communications with a terrestrial ground station. Different from existing space-borne quantum communication platforms, our new platform will be based on CV (Continuous Variable) technology and will integrate the ability to seamlessly switch to classical Free-Space Optical communications when channel conditions deem quantum communications are .... A Space-Based Quantum Communications Platform using Continuous Variables. This work proposes to investigate a new space-borne platform capable of quantum communications with a terrestrial ground station. Different from existing space-borne quantum communication platforms, our new platform will be based on CV (Continuous Variable) technology and will integrate the ability to seamlessly switch to classical Free-Space Optical communications when channel conditions deem quantum communications are too difficult. Currently no quantum satellite built on CV technology exists. Our research will produce a significant advance in an emerging technology space, and will allow Australia to take scientific leadership in an important aspect of ultra-secure communications from satellites.
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Nanostructure engineered low activation superconductors for fusion energy. This project aims to develop a novel, low activation and liquid helium-free superconducting solution with superior electromagnetic, mechanical and thermal properties for use in fusion reactors. Superconducting magnets and their associated cryogenic cooling systems represent a key determinant of thermal efficiency and the construction/operating costs of fusion reactors. The project expects to overcome these barriers so tha ....Nanostructure engineered low activation superconductors for fusion energy. This project aims to develop a novel, low activation and liquid helium-free superconducting solution with superior electromagnetic, mechanical and thermal properties for use in fusion reactors. Superconducting magnets and their associated cryogenic cooling systems represent a key determinant of thermal efficiency and the construction/operating costs of fusion reactors. The project expects to overcome these barriers so that widespread uptake of these reactors becomes viable. Outcomes from the project will include a fundamental understanding of pure and doping-induced isotopic magnesium diboride superconductors and their behaviour under high neutron flux and harsh plasma atmosphere, which are specifically designed for application in next-generation, low-cost fusion reactors.Read moreRead less
Next generation lasers for short-reach optical fibre communication. This project aims to develop next-generation laser systems for multimode fibre-optic communication systems, by leveraging recently developed techniques for measuring and controlling the spatial properties of light. These techniques will provide new insights into the physics of the lasers themselves, as well as overcoming fundamental limitations which have traditionally hindered their operation at high speed. The expected outcome ....Next generation lasers for short-reach optical fibre communication. This project aims to develop next-generation laser systems for multimode fibre-optic communication systems, by leveraging recently developed techniques for measuring and controlling the spatial properties of light. These techniques will provide new insights into the physics of the lasers themselves, as well as overcoming fundamental limitations which have traditionally hindered their operation at high speed. The expected outcome of this project is the inclusion of these techniques in the development and operation of future generations of fibre communication systems. Creating new classes of laser systems, which can scale to large bit rates, will enable the growth in this area to be sustained into the future.Read moreRead less
Neural circuit control of effort under stress . This Project aims to investigate how the ‘decision’ to persist in exerting effort to obtain a reward is encoded in the the brain and affected by stress. This work will generate new knowledge on the neural mechanisms through which stress modifies neural activity to control decision making processes underpinning adaptive behaviours essential for survival. The expected outcomes of this work include enhanced capacity at the interface of behavioural a ....Neural circuit control of effort under stress . This Project aims to investigate how the ‘decision’ to persist in exerting effort to obtain a reward is encoded in the the brain and affected by stress. This work will generate new knowledge on the neural mechanisms through which stress modifies neural activity to control decision making processes underpinning adaptive behaviours essential for survival. The expected outcomes of this work include enhanced capacity at the interface of behavioural and computational neuroscience, that will in turn provide significant benefits through greater insight into brain functions essential for survival, with long ranging implications for performance optimisation and brain-inspired computing. Read moreRead less