Intravital super-resolution imaging via Stimulated Emission Depletion microscopy (STED)-microendoscopy. We will develop a new technology to enable the imaging of sub-cellular structures within a biological specimen, with super-resolution. This intravital super-resolution imaging technology will build off world leading techniques to image objects with super-resolution and to perform this within a specimen, with minimal invasion. The broad ramifications of this technology apply to biology, medical ....Intravital super-resolution imaging via Stimulated Emission Depletion microscopy (STED)-microendoscopy. We will develop a new technology to enable the imaging of sub-cellular structures within a biological specimen, with super-resolution. This intravital super-resolution imaging technology will build off world leading techniques to image objects with super-resolution and to perform this within a specimen, with minimal invasion. The broad ramifications of this technology apply to biology, medical science, imaging and sensing. Important applications include the early detection of debilitating diseases and the advancement of understanding of cellular biology. This research will raise Australia's profile as a world leader in science and technology, building on our emerging presence in the biophysical sciences.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347356
Funder
Australian Research Council
Funding Amount
$238,000.00
Summary
Real-time multi-dimensional multi-photon microscopy facility. The proposal seeks to establish an integrated microscopy facility and thus to expand the high-resolution imaging capabilities at Swinburne University of Technology, Peter MacCallum Cancer Institute and the University of Melbourne. The provision of the equipment requested will establish an innovative real-time multi-dimensional multi-photon imaging facility of world class. This facility will be accessed on a cooperative basis by the pa ....Real-time multi-dimensional multi-photon microscopy facility. The proposal seeks to establish an integrated microscopy facility and thus to expand the high-resolution imaging capabilities at Swinburne University of Technology, Peter MacCallum Cancer Institute and the University of Melbourne. The provision of the equipment requested will establish an innovative real-time multi-dimensional multi-photon imaging facility of world class. This facility will be accessed on a cooperative basis by the participants and will be available for collaborative projects with other Australian institutions and industry. The requested equipment will be used in conjunction with existing femtosecond laser and lifetime imaging systems installed in the research laboratories of the participating institutions. The facility will enable real-time investigations of biomolecular processes and the development of novel biomedical imaging techniques as well as the state-of-the-art nanophotonic devices such as nano-tweezers and nano compact disks.Read moreRead less
Diffractive Imaging using Soft X-rays and Electrons. Optical, electron and x-ray microscopy has yielded enormous biological insights and medical benefits to society. Optical microscopy is able to image live tissue, but at relatively low resolution. Electron microscopy can yield high resolution images, but only of highly prepared material. X-ray microscopy yields images of live tissue with a resolution that is intermediate between optical and electron microscopy. This project will provide Austral ....Diffractive Imaging using Soft X-rays and Electrons. Optical, electron and x-ray microscopy has yielded enormous biological insights and medical benefits to society. Optical microscopy is able to image live tissue, but at relatively low resolution. Electron microscopy can yield high resolution images, but only of highly prepared material. X-ray microscopy yields images of live tissue with a resolution that is intermediate between optical and electron microscopy. This project will provide Australian scientists with their first access to x-ray microscopy at its optimum wavelength; and secondly it will provide a superb testbed for x-ray microscopy to be enhanced using unique methods being developed in Australia.Read moreRead less
Optical manipulation of single molecules in nanocontainers and nanotubes. Modern medicine has benefited greatly from technological advances in instrumentation. The ability to probe and manipulate new aspects of biological function often provides unique information that can be used as the basis of new medical treatments. Recent advances in optical instrumentation and biochemical labelling has enabled the study of biological function at the single molecule level. This project proposes to develop n ....Optical manipulation of single molecules in nanocontainers and nanotubes. Modern medicine has benefited greatly from technological advances in instrumentation. The ability to probe and manipulate new aspects of biological function often provides unique information that can be used as the basis of new medical treatments. Recent advances in optical instrumentation and biochemical labelling has enabled the study of biological function at the single molecule level. This project proposes to develop new techniques in single molecule manipulation, to perform studies not easily addressable using current techniques. The proposed research will form the basis of an enabling technology for Australian researchers to make breakthroughs in biomedical research, potentially leading to improvements in healthcare.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989915
Funder
Australian Research Council
Funding Amount
$127,000.00
Summary
X-ray Nano-scale Coherence Facility. Australia is rapidly developing into a world leader for x-ray imaging. This position has been supported by leading research groups and more recently by the development of the Australian Synchrotron. This project will fill a vital missing link in the experimental capability of Australian researchers - a flexible facility that can provide a nanoscale x-ray source. This enhanced capability will lead to new developments in coherent imaging methods. These new meth ....X-ray Nano-scale Coherence Facility. Australia is rapidly developing into a world leader for x-ray imaging. This position has been supported by leading research groups and more recently by the development of the Australian Synchrotron. This project will fill a vital missing link in the experimental capability of Australian researchers - a flexible facility that can provide a nanoscale x-ray source. This enhanced capability will lead to new developments in coherent imaging methods. These new methods will be used in the study of biological systems, leading to better drug design as well as in the study of materials, leading to stronger and lighter components. Read moreRead less
Generalized imaging systems incorporating hybrid hardware-software optics. Fundamental optics research underpins the commercial optical technologies of tomorrow. Modern examples of such evolution, from the fundamental to the commercial, include lasers, LED traffic lights, thin-screen computer monitors and digital cameras. The recent advent of accessible powerful computers, together with recent advances in optical physics, promise a powerful merging of computing and optical technologies into so ....Generalized imaging systems incorporating hybrid hardware-software optics. Fundamental optics research underpins the commercial optical technologies of tomorrow. Modern examples of such evolution, from the fundamental to the commercial, include lasers, LED traffic lights, thin-screen computer monitors and digital cameras. The recent advent of accessible powerful computers, together with recent advances in optical physics, promise a powerful merging of computing and optical technologies into so-called virtual optical systems in which the computer processes optical information in a manner very similar to lenses. In particular, the computer may be used to decode distorted images provided by an imperfect imaging system. Read moreRead less
The Mechanics of Nanoscale Devices. Australian developments in biosensing, medical diagnostics, clean energy, communication and security technologies, are rapidly growing due to our mounting capacity in nanoscale fabrication. Vital for evolution of next-generation nanodevices is an understanding of how mechanical processes operate at such small scales. This application will contribute to this scientific knowledge base. This will in turn assist Australian industries to progress these applications ....The Mechanics of Nanoscale Devices. Australian developments in biosensing, medical diagnostics, clean energy, communication and security technologies, are rapidly growing due to our mounting capacity in nanoscale fabrication. Vital for evolution of next-generation nanodevices is an understanding of how mechanical processes operate at such small scales. This application will contribute to this scientific knowledge base. This will in turn assist Australian industries to progress these applications and devices, leading to economic, social and technological gains for the Australian community.Read moreRead less
Bifurcations of dissipative solitons. Fundamental research on the basic concepts of solitons in dissipative systems and their bifurcations is the next essential step for further progress in the science of optical pulse generators and amplifiers. Australia was the first country in the world to use self-organized ultra-short pulses, called solitons, in a commercially-deployed optical transmission line. This proposed new research will answer the question of how solitons behave at the ultimate limi ....Bifurcations of dissipative solitons. Fundamental research on the basic concepts of solitons in dissipative systems and their bifurcations is the next essential step for further progress in the science of optical pulse generators and amplifiers. Australia was the first country in the world to use self-organized ultra-short pulses, called solitons, in a commercially-deployed optical transmission line. This proposed new research will answer the question of how solitons behave at the ultimate limits of optics. New principles of ultra-short pulse generation and amplification, developed in our research, will provide the basis for an unprecedented increase in the capacity of optical transmission and processing of information.Read moreRead less
Dissipative soliton resonances and their applications. Many branches of science and technology, such as precise eye surgery, biological cell machinery, painless dentistry, optical data storage, material micro-machining and laser fusion, rely heavily on high power femtosecond pulse laser oscillators that deliver the necessary power, in a very short time, to nanometer scale targets within a tissue or a material. A further increase in the power of a pulse and a decrease in its duration, combined wi ....Dissipative soliton resonances and their applications. Many branches of science and technology, such as precise eye surgery, biological cell machinery, painless dentistry, optical data storage, material micro-machining and laser fusion, rely heavily on high power femtosecond pulse laser oscillators that deliver the necessary power, in a very short time, to nanometer scale targets within a tissue or a material. A further increase in the power of a pulse and a decrease in its duration, combined with a reduction in complexity and price can be achieved, but this advance depends strongly on the theory of dissipative solitons, and particularly on the idea of soliton resonances. Novel ideas developed within this project will put new productive tools in the hands of doctors, biologists and physicists.Read moreRead less
Spin-dependent interactions: a fundamental basis for spin-electronics. This project will establish a comprehensive understanding of spin-dependent interactions and correlated behaviour of multi-electron systems that are responsible for spin-relaxation, spin transport and spin coherence in spin-electronic devices. Our approach is based on the spin-resolved two-electron coincidence spectroscopy that is inherently suited for studying electronic correlations. Systematic investigations of spin-depend ....Spin-dependent interactions: a fundamental basis for spin-electronics. This project will establish a comprehensive understanding of spin-dependent interactions and correlated behaviour of multi-electron systems that are responsible for spin-relaxation, spin transport and spin coherence in spin-electronic devices. Our approach is based on the spin-resolved two-electron coincidence spectroscopy that is inherently suited for studying electronic correlations. Systematic investigations of spin-dependent interactions in atoms, molecules and ultrathin films will increase understanding of magnetic (spin) properties of artificially structured materials with reduced dimensionality for the benefit of nanotechnology. This understanding will be used to design and control, at the quantum mechanical level, the building blocks of spin-electronic devices.Read moreRead less