An efficient approach to the computation of bacterial evolutionary distance. This project aims to apply advanced mathematical tools to improve our understanding of bacterial evolution. Bacteria account for as much total Earth biomass as all plant species put together, and have an unparalleled ability to evolve quickly and adapt to changing environments. Unfortunately, the existing mathematical models used to model bacterial evolution are generally computationally intractable. This project will r ....An efficient approach to the computation of bacterial evolutionary distance. This project aims to apply advanced mathematical tools to improve our understanding of bacterial evolution. Bacteria account for as much total Earth biomass as all plant species put together, and have an unparalleled ability to evolve quickly and adapt to changing environments. Unfortunately, the existing mathematical models used to model bacterial evolution are generally computationally intractable. This project will rectify this situation by using representation theory to transform combinatorial group theory into linear algebra, allowing for the application of advanced methods of numeric approximation. This will provide a better understanding of how bacteria evolve and improve our ability to manage their impact.Read moreRead less
How does warming prevent soil nitrogen availability from declining in response to elevated CO2? The sustainable use of the terrestrial environment depends upon maintaining ecosystem productivity which in turn depends upon nutrient availability within the soil. Increasing levels of CO2 in the atmosphere are known to decrease nutrient availability while warming prevents this from happening. The aims of this project are to determine how warming is able to prevent elevated CO2 concentrations from re ....How does warming prevent soil nitrogen availability from declining in response to elevated CO2? The sustainable use of the terrestrial environment depends upon maintaining ecosystem productivity which in turn depends upon nutrient availability within the soil. Increasing levels of CO2 in the atmosphere are known to decrease nutrient availability while warming prevents this from happening. The aims of this project are to determine how warming is able to prevent elevated CO2 concentrations from reducing soil N availability and hence productivity in a native grassland ecosystems. This is important, as it will allow likely problems caused by global climate change to be predicted by increasing the understanding of the underlying mechanisms as well as improving the management of grasslands in an environmentally sustainable way. Read moreRead less
Carbon in - carbon out: can carbon inputs keep up with losses in peatland? This project aims to quantify the current and predict the future carbon balance of a high altitude, carbon-dense ecosystem, namely sub-alpine grassy peatland, by measuring how environmental variables including experimental warming control the fluxes of carbon and water into and out of the system. In this way, this project will produce new knowledge on the susceptibility of high-altitude peaty soils to climate change. Expe ....Carbon in - carbon out: can carbon inputs keep up with losses in peatland? This project aims to quantify the current and predict the future carbon balance of a high altitude, carbon-dense ecosystem, namely sub-alpine grassy peatland, by measuring how environmental variables including experimental warming control the fluxes of carbon and water into and out of the system. In this way, this project will produce new knowledge on the susceptibility of high-altitude peaty soils to climate change. Expected outcomes include an enhanced ability to predict future carbon accumulation rates and the resilience of the vital water-storage and filtration services provided by these systems. This project will enhance outputs from new infrastructure and assist planning for future flood and drought management across SE Australia.Read moreRead less
Understanding the mechanisms underpinning complex sociality. This project aims to investigate the mechanisms underlying the formation of complex social systems in vertebrates. Our understanding of these mechanisms is strongly biased towards a few model systems. We have identified a novel Australian model system with a wide range of sociality for this purpose. This project expects to generate new knowledge on how the social environment interacts with the brain during social organisation. Expected ....Understanding the mechanisms underpinning complex sociality. This project aims to investigate the mechanisms underlying the formation of complex social systems in vertebrates. Our understanding of these mechanisms is strongly biased towards a few model systems. We have identified a novel Australian model system with a wide range of sociality for this purpose. This project expects to generate new knowledge on how the social environment interacts with the brain during social organisation. Expected outcomes include the refinement of social theory and capacity building via international collaboration and postgraduate training. This work will provide significant benefits by increasing our understanding of how the brain and social environment interact to moderate aggression and enhance social associations.Read moreRead less
Evolutionary history and impact of adeno-associated viruses in Australia. Recently accrued evidence identifies Australia as an ideal closed-model system in which to elucidate the evolutionary history of a group of non-pathogenic viruses, known as adeno-associated viruses (AAVs). This project aims to trace back the evolutionary history of AAVs for tens of millions of years via molecular fossil imprints left behind by ancient viral invasions of Australian marsupial genomes. Concurrently, the poten ....Evolutionary history and impact of adeno-associated viruses in Australia. Recently accrued evidence identifies Australia as an ideal closed-model system in which to elucidate the evolutionary history of a group of non-pathogenic viruses, known as adeno-associated viruses (AAVs). This project aims to trace back the evolutionary history of AAVs for tens of millions of years via molecular fossil imprints left behind by ancient viral invasions of Australian marsupial genomes. Concurrently, the potential impact that these viral invasions had on the evolutionary development of their ancestral hosts will be investigated. This could facilitate previously unattainable insights into both AAV and marsupial evolution, with broader implications relevant to the advancement of the fields of virology and mammalian evolution.Read moreRead less
Micro-electrofluidic platforms for monitoring 3D human biological models. The ability to study living cells and human biological models (cell cultures) delivers greater understanding of basic biological function and response to applied (bio)chemical stimuli. Creating the physical environments to sustain biological models, and mimic natural conditions and fluidic pathways, is immensely challenging, yet essential to deliver meaningful observational data. This project will deliver this capability t ....Micro-electrofluidic platforms for monitoring 3D human biological models. The ability to study living cells and human biological models (cell cultures) delivers greater understanding of basic biological function and response to applied (bio)chemical stimuli. Creating the physical environments to sustain biological models, and mimic natural conditions and fluidic pathways, is immensely challenging, yet essential to deliver meaningful observational data. This project will deliver this capability through the convergence of expertise and innovation in analytical chemistry, materials science and cellular biology, ultilising the latest technology and understanding of 3D micro/electrofluidics, to enable the study and stimulation of advanced biological models, sustained within precisely controlled 3D micro-environments.Read moreRead less
Lags and legacies: antecedent effects on grassland biomass response to carbon dioxide. This project aims to assess how past conditions influence grassland responses to the rising atmospheric concentration of carbon dioxide. High CO2 concentrations should stimulate productivity but in grasslands this is rarely realised because other, mostly unknown, factors constrain the response. By synthesising data from past experiments, this project aims to determine exactly why grasslands fail to realise the ....Lags and legacies: antecedent effects on grassland biomass response to carbon dioxide. This project aims to assess how past conditions influence grassland responses to the rising atmospheric concentration of carbon dioxide. High CO2 concentrations should stimulate productivity but in grasslands this is rarely realised because other, mostly unknown, factors constrain the response. By synthesising data from past experiments, this project aims to determine exactly why grasslands fail to realise the full productivity benefits of increased CO2 and when this will happen. This should improve predictions of carbon exchange and indicating the best direction for climate change adaptation measures.Read moreRead less
Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Detecting and deciphering extinction dynamics under environmental change. This project aims to improve knowledge of extinction processes and impacts. It will use high-performance computing and museum collections to disentangle the ecological mechanisms that were integral in the initial decline and later extinction of Australia's unique mammals. Its significance is that it will establish the historical ranges and past population trajectories of Australian threatened mammals, pinpointing the combi ....Detecting and deciphering extinction dynamics under environmental change. This project aims to improve knowledge of extinction processes and impacts. It will use high-performance computing and museum collections to disentangle the ecological mechanisms that were integral in the initial decline and later extinction of Australia's unique mammals. Its significance is that it will establish the historical ranges and past population trajectories of Australian threatened mammals, pinpointing the combinations of ecological characteristics and threats that most affect risk of extinction from environmental change. Expected outcomes and benefits are new data and verified models to enrich conservation research and inform evidence-based solutions to better protect and recover some of Australia’s most threatened species.Read moreRead less
Lamarckian lizards: novel integration of telomere epigenetics, free radicals and innate antioxidants in condition-dependant sexual signal evolution. In 2009, the Nobel Prize in physiology was awarded Drs. Blackburn, Greider and Szostak for discoveries on telomeres. This project will investigate how telomeres not only cap chromosomes from destruction by free radicals, but also have a key role in life itself, in their influence on ageing, longevity, ornaments and lifetime reproductive success.