Visualisation of latent DNA. This project aims to deliver a proof-of-concept that allows visualisation of invisible DNA (latent DNA) into a quick, inexpensive and practical DNA collection method that will lead to DNA evidence being available in more cases. It will build upon a proof-of-concept method ready for transferal to forensic casework. This will allow DNA evidence recovery technicians to improve their hit rate in recovering latent DNA from real crime items, leading to more informative DNA ....Visualisation of latent DNA. This project aims to deliver a proof-of-concept that allows visualisation of invisible DNA (latent DNA) into a quick, inexpensive and practical DNA collection method that will lead to DNA evidence being available in more cases. It will build upon a proof-of-concept method ready for transferal to forensic casework. This will allow DNA evidence recovery technicians to improve their hit rate in recovering latent DNA from real crime items, leading to more informative DNA profiles. Crime items that currently yield no genetic information will now be informative, assisting investigations of serious crimes or terrorist incidents.Read moreRead less
Early warning of cyanobacteria blooms in drinking water reservoirs by means of evolutionary algorithms. Estimated economic cost of cyanobacteria blooms to Australia are at $150 million p.a. Early warning for cyanobacteria blooms will inform water managers to conduct preventive and operational control in reservoirs and water works, and significantly lower risks for public health and costs for monitoring and treatment. Resulting early warning systems will be novel prototypes for cyanobacteria bloo ....Early warning of cyanobacteria blooms in drinking water reservoirs by means of evolutionary algorithms. Estimated economic cost of cyanobacteria blooms to Australia are at $150 million p.a. Early warning for cyanobacteria blooms will inform water managers to conduct preventive and operational control in reservoirs and water works, and significantly lower risks for public health and costs for monitoring and treatment. Resulting early warning systems will be novel prototypes for cyanobacteria blooms in drinking water reservoirs based on forecasting models adaptable to environmental and climate change. Model-based scenario analysis will also assist in informed decisions on effects of drought, injection of recycled water and global warming to cyanobacteria growth.Read moreRead less
Mechanisms controlling enteroendocrine hormone secretion in human duodenum. This project aims to gain a deeper understanding of nutrient sensing pathways present in enteroendocrine cells within the human intestine. These cells control digestive function, blood glucose levels and food intake and are thus critical to digestion. This project will endeavour to be the first to assess the biology of human enteroendocrine cells and will use innovative approaches to deeply assess function from the level ....Mechanisms controlling enteroendocrine hormone secretion in human duodenum. This project aims to gain a deeper understanding of nutrient sensing pathways present in enteroendocrine cells within the human intestine. These cells control digestive function, blood glucose levels and food intake and are thus critical to digestion. This project will endeavour to be the first to assess the biology of human enteroendocrine cells and will use innovative approaches to deeply assess function from the level of the individual to isolated enteroendocrine cells.Read moreRead less
Ecology, morphology and the diversification of Australian lizards. This project aims to determine the factors driving the spectacular radiation of lizards in Australia. To date, most investigations of lizard anatomy have focused exclusively on external characteristics. This project will examine the underlying internal anatomy to investigate whether morphological innovation is associated with enhanced rates of ecological, life-history and species diversification. The project expects to shed light ....Ecology, morphology and the diversification of Australian lizards. This project aims to determine the factors driving the spectacular radiation of lizards in Australia. To date, most investigations of lizard anatomy have focused exclusively on external characteristics. This project will examine the underlying internal anatomy to investigate whether morphological innovation is associated with enhanced rates of ecological, life-history and species diversification. The project expects to shed light on the evolution of Australia’s most diverse vertebrate lineage, and provide comparative data with which to interpret the lizard fossil record in Australia, and the range declines and relative extinction risks of native lizard species.Read moreRead less
Mechanisms and management of inducible tolerance to synthetic insecticides and Bacillus thuringiensis (Bt)-formulations in Australian populations of diamondback moth. Insects have a cunning ability to respond to damaging environments by evolving genetic resistance or mobilising metabolic tolerance mechanisms. Recent observations of inducible tolerance to synthetic and biopesticides, which can be transmitted to offspring by a maternal effect has the potential to cause ecological and economic prob ....Mechanisms and management of inducible tolerance to synthetic insecticides and Bacillus thuringiensis (Bt)-formulations in Australian populations of diamondback moth. Insects have a cunning ability to respond to damaging environments by evolving genetic resistance or mobilising metabolic tolerance mechanisms. Recent observations of inducible tolerance to synthetic and biopesticides, which can be transmitted to offspring by a maternal effect has the potential to cause ecological and economic problems in agricultural production. We will use field-collected Diamondback moth (DBM), a major insect pest in canola and brassica vegetable crops, to investigate the genetic implications of inducible tolerance for the integrated management of DBM and for the design of new resistance management strategies.Read moreRead less
Early Nutrition and the Programming of Body Composition in Cattle. Australia is the worlds largest beef exporter with the net value of beef export valued at $4.6 billion. The economy of rural and regional Australia relies upon cattle production with the industry bringing a total value to these communities of $7.4 billion. Cattle production in remote Australia is becoming less viable as input costs of production increase relative to income earned and the beef industry is keen to transform produc ....Early Nutrition and the Programming of Body Composition in Cattle. Australia is the worlds largest beef exporter with the net value of beef export valued at $4.6 billion. The economy of rural and regional Australia relies upon cattle production with the industry bringing a total value to these communities of $7.4 billion. Cattle production in remote Australia is becoming less viable as input costs of production increase relative to income earned and the beef industry is keen to transform production methods. Protein is the major limiting nutrient in the Australian rangelands and this proposal will provide new information on how providing protein to cattle during critical periods in their pregnancy can 'program' the body composition of the growing calf to be optimal for the market.Read moreRead less
Beneficial arthropods in Coonawarra vineyards and sustainable grape production. Many species of pest and beneficial arthropods live in vines and groundcover of vineyards. Vignerons often devote considerable effort to sustain populations of what they believe to be beneficial arthropods. However, the types of natural enemies and techniques to enhance their effectiveness are poorly known. This project aims to identify and quantify the role of natural enemies in controlling the main pest in Coonawar ....Beneficial arthropods in Coonawarra vineyards and sustainable grape production. Many species of pest and beneficial arthropods live in vines and groundcover of vineyards. Vignerons often devote considerable effort to sustain populations of what they believe to be beneficial arthropods. However, the types of natural enemies and techniques to enhance their effectiveness are poorly known. This project aims to identify and quantify the role of natural enemies in controlling the main pest in Coonawarra vineyards, identify their food and shelter requirements, and improve management practices and other techniques to optimise populations of beneficial species. The significance of this project is that it will enable the promotion of insecticide-free production of winegrapes in the Coonawarra.Read moreRead less
Development and implementation of biodiversity information for sustainable management of South Australian groundwater. Clean potable water is one of the most important resources for human health and a successful economy. Increasingly, subterranean aquifers are used for storage and recovery of water. These aquifers contain dynamic ecosystems, but little is known about species composition or about the importance of the presence of various species for water quality. We will use the latest laborator ....Development and implementation of biodiversity information for sustainable management of South Australian groundwater. Clean potable water is one of the most important resources for human health and a successful economy. Increasingly, subterranean aquifers are used for storage and recovery of water. These aquifers contain dynamic ecosystems, but little is known about species composition or about the importance of the presence of various species for water quality. We will use the latest laboratory techniques and DNA identification methods to provide a template for determining ground water diversity and food web dynamics throughout Australia. This project will lead to a better understanding of how to manage ground water in a sustainable manner.Read moreRead less
Understanding gender differences in pain: Cellular therapies for animal pain. Understanding gender differences in pain: Cellular therapies for animal pain. This project aims to relieve chronic pain in animals and lay the foundations for future human therapies, using molecular assays, cell technologies and immune/hormonal pain generators. Chronic pain affects females more than males. Establishing the fundamental mechanism in pain, the role of immune signalling and molecular mediators will enable ....Understanding gender differences in pain: Cellular therapies for animal pain. Understanding gender differences in pain: Cellular therapies for animal pain. This project aims to relieve chronic pain in animals and lay the foundations for future human therapies, using molecular assays, cell technologies and immune/hormonal pain generators. Chronic pain affects females more than males. Establishing the fundamental mechanism in pain, the role of immune signalling and molecular mediators will enable true pain-modifying treatments that address pivotal triggers in both genders. This project will then use specially selected stem cells separately targeting arthritic male and female pain and demonstrate novel veterinary chronic pain treatments. Expected outcomes are more effective gender-targeted treatments of pain and the realisation of economic value of molecular assays and cell technologies.Read moreRead less
Finding the targets of natural products in complex botanical extracts. Many plants are used for nutritional and traditional medicine purposes and have demonstrated, evidence based effects. However, standard methods to identify single chemical compounds responsible for the observed effects fail as they rely on a single compound having a single target and ignore the overall effects of many interacting compounds on many targets. In this application we propose a new method to simultaneously identify ....Finding the targets of natural products in complex botanical extracts. Many plants are used for nutritional and traditional medicine purposes and have demonstrated, evidence based effects. However, standard methods to identify single chemical compounds responsible for the observed effects fail as they rely on a single compound having a single target and ignore the overall effects of many interacting compounds on many targets. In this application we propose a new method to simultaneously identify the molecular targets of many compounds in complex plant extracts, along with their subsequent validation by responses in gene expression to the plant extract. This research will revolutionise understanding of the nutritional and medicinal effects of plants and will allow our partners to accelerate commercialisation. Read moreRead less