Paving the way for ultra-long haul flights: strategies to mitigate jetlag. This project aims to develop and test strategies to mitigate jetlag, founded on biophysical modelling of circadian rhythms. It sets out to quantify the speed of circadian adaptation of sleep, alertness, and metabolism after transmeridian travel and to maximise speed of adaptation via optimised timing of light exposure, food, and exercise in-flight and on-the-ground. Expected outcomes include powerful models for jetlag str ....Paving the way for ultra-long haul flights: strategies to mitigate jetlag. This project aims to develop and test strategies to mitigate jetlag, founded on biophysical modelling of circadian rhythms. It sets out to quantify the speed of circadian adaptation of sleep, alertness, and metabolism after transmeridian travel and to maximise speed of adaptation via optimised timing of light exposure, food, and exercise in-flight and on-the-ground. Expected outcomes include powerful models for jetlag strategies, ready for application in air travel. The project will directly inform Qantas’ operations for ultra-long haul flights and their international network more broadly. Project outcomes will benefit society and the economy through improving travellers’ alertness, sleep, and reducing the risk of fatigue-related accidents.Read moreRead less
Special Research Initiatives - Grant ID: SR0354636
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Australian Computational Molecular Science Network. Computational Molecular Science (CMS) involves the use of theory and computational methods to simulate and visualise molecular systems ranging from small atmospheric species to proteins, nucleic acids, chemical polymers and materials. It represents our most incisive expression of what we understand about the molecular basis of nature. The CMS network will integrate and cross-fertilize both fundamental and application-based expertize in molecula ....Australian Computational Molecular Science Network. Computational Molecular Science (CMS) involves the use of theory and computational methods to simulate and visualise molecular systems ranging from small atmospheric species to proteins, nucleic acids, chemical polymers and materials. It represents our most incisive expression of what we understand about the molecular basis of nature. The CMS network will integrate and cross-fertilize both fundamental and application-based expertize in molecular scale computations in the fields of nanoscience, biomaterials, biotechnology, biomedical science and environmental science. It will uncover and explore critical new interdisciplinary science and create new molecular-based paradigms that will drive advances in these fields over the next decade.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883036
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials, and Medical Research. The expected benefits that will arise will include: green chemical processes with improved environmental and economic impacts; improved treatments and diagnoses of diseases; understanding of fundamental geological processes; identification of the earliest forms; studies of archaeological artefacts; evolution of life on Earth; the design of improved dental materials. Ultimatel ....Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials, and Medical Research. The expected benefits that will arise will include: green chemical processes with improved environmental and economic impacts; improved treatments and diagnoses of diseases; understanding of fundamental geological processes; identification of the earliest forms; studies of archaeological artefacts; evolution of life on Earth; the design of improved dental materials. Ultimately, this research will include economic and social benefits in; industrial processes; the mining industry; medicine; and dentistry. An understanding of the origin and early evolution of life on Earth also has many social implications.Read moreRead less
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Targeted mining for new drugs against parasitic nematodes of animals - a synergy of integrated, frontier technologies and a committed partnership with industry. This project will: develop a quality scientific and technological program in national priority areas, leading to a strong basic research, new concepts and the enhanced international collaborative links; strengthen links between basic and applied research, and academia and industry; develop excellence via pan-Australian collaborations, re ....Targeted mining for new drugs against parasitic nematodes of animals - a synergy of integrated, frontier technologies and a committed partnership with industry. This project will: develop a quality scientific and technological program in national priority areas, leading to a strong basic research, new concepts and the enhanced international collaborative links; strengthen links between basic and applied research, and academia and industry; develop excellence via pan-Australian collaborations, resulting in a more efficient use of resources in a national and international context; enhance the skills-base in biology, biotechnology and bioinformatics; increase global visibility with increased investment in Australian science; improved animal welfare and production via better control of infectious diseases; commercial products with benefits to agricultural producers in regional and rural communities.Read moreRead less
Characterisation of tumour variants of Devil Facial Tumour Disease. This project will take a new approach to cancer research by studying the evolution of Devil Facial Tumour Disease. The results will directly contribute to the conservation management of the Tasmanian devil, as well as generating new information on tumour growth, metastasis and emergence of resistance.
Unpacking the immune system with applied mathematics. This project aims to model immune interactions across cells and structures spanning scales of nanometres to millimetres. It expects to develop innovative mathematical insights, improve our understanding of immunology, and consolidate collaborations with top American and European laboratories and groups. Expected outcomes include cutting-edge techniques for multiscale biological modelling and improved prediction and analysis of immune dynami ....Unpacking the immune system with applied mathematics. This project aims to model immune interactions across cells and structures spanning scales of nanometres to millimetres. It expects to develop innovative mathematical insights, improve our understanding of immunology, and consolidate collaborations with top American and European laboratories and groups. Expected outcomes include cutting-edge techniques for multiscale biological modelling and improved prediction and analysis of immune dynamics. The project should provide benefits to industries where highly organised behaviours are important, for example those interested in robot swarming, optimal transportation, and epidemic management. It should also benefit Australian students and researchers with novel overseas training opportunities.Read moreRead less
Molecular study of copper-promoted ubiquitination. This project aims to study copper-promoted ubiquitination, a novel discovery that a conserved copper binding site in conjugating enzyme UBE2D2 promotes ubiquitination of a range of proteins including tumor suppressor p53. It predicts a correlation between copper homeostasis and cellular proteostasis and may rationalise an inverse relationship between Alzheimer's disease and cancer. This project will employ a range of integrated approaches to ill ....Molecular study of copper-promoted ubiquitination. This project aims to study copper-promoted ubiquitination, a novel discovery that a conserved copper binding site in conjugating enzyme UBE2D2 promotes ubiquitination of a range of proteins including tumor suppressor p53. It predicts a correlation between copper homeostasis and cellular proteostasis and may rationalise an inverse relationship between Alzheimer's disease and cancer. This project will employ a range of integrated approaches to illuminate the molecular nature of this copper action. Expected outcomes include an understanding of the molecular mechanisms of this process, and enhanced interdisciplinary collaboration. Potential benefits include new strategies to intervene in copper-related disorders.Read moreRead less
Dynamical systems theory and mathematical modelling of viral infections. This project aims to use mathematical modelling to elucidate the emergence of complex, population-level behaviour from local interactions. In particular, the project will study the self-organising dynamics of the immune response. The project expects to develop new mathematical models of self-organisation, advance links between computational agent-based modelling and dynamical systems modelling, and build new tools for mat ....Dynamical systems theory and mathematical modelling of viral infections. This project aims to use mathematical modelling to elucidate the emergence of complex, population-level behaviour from local interactions. In particular, the project will study the self-organising dynamics of the immune response. The project expects to develop new mathematical models of self-organisation, advance links between computational agent-based modelling and dynamical systems modelling, and build new tools for mathematically analysing complex biological systems. Expected outcomes include strengthened collaborations within Australia and with South Korea. Expected benefits include joint research funding with Korean institutions, increased international visibility, and expanded scope for high school and community outreach.Read moreRead less
Targeted isolation of specific marine bacterial species associated with higher organsims for the purpose of discovering new antimicrobial compounds. Specific bacterial species that are commonly found in association with marine plants and animals often produce active secondary metabolites. The aim of this project is to apply our understanding of these bacterial-host associations to the targeted isolation of novel antimicrobials from the marine environment. While these new compounds will undoubted ....Targeted isolation of specific marine bacterial species associated with higher organsims for the purpose of discovering new antimicrobial compounds. Specific bacterial species that are commonly found in association with marine plants and animals often produce active secondary metabolites. The aim of this project is to apply our understanding of these bacterial-host associations to the targeted isolation of novel antimicrobials from the marine environment. While these new compounds will undoubtedly have a number of commercial applications this project focuses on the development of products for dental hygiene in animals. Generally, the urgent need for new antimicrobial compounds to combat the growing number of microbes that are resistant to current antibiotics highlights the importance of this project.Read moreRead less