Discovery Early Career Researcher Award - Grant ID: DE190100694
Funder
Australian Research Council
Funding Amount
$372,014.00
Summary
Does disconnection in the aging brain cause age-related movement decline? This project aims to use new neurophysiological approaches to understand the causal role of age-related changes in brain network connectivity to the movement control. Brain regions interact through complex and dynamic neural networks to control voluntary movement, but whether age-related changes in network connectivity drive age-related decline in movement control is unknown. This project will provide significant benefits ....Does disconnection in the aging brain cause age-related movement decline? This project aims to use new neurophysiological approaches to understand the causal role of age-related changes in brain network connectivity to the movement control. Brain regions interact through complex and dynamic neural networks to control voluntary movement, but whether age-related changes in network connectivity drive age-related decline in movement control is unknown. This project will provide significant benefits such as the neurophysiological knowledge required to develop targeted interventions to improve movement control in the aging population.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100575
Funder
Australian Research Council
Funding Amount
$423,604.00
Summary
Does neuroplasticity protect against late life cognitive impairment? This project aims to investigate neuroplasticity across the adult lifespan, using novel neurophysiological approaches to determine its role in protecting against age-related cognitive decline. This project expects to generate new knowledge in the area of human cognitive ageing, using an innovative and interdisciplinary approach. Expected outcomes of this project include a critical understanding of the basic neural mechanisms of ....Does neuroplasticity protect against late life cognitive impairment? This project aims to investigate neuroplasticity across the adult lifespan, using novel neurophysiological approaches to determine its role in protecting against age-related cognitive decline. This project expects to generate new knowledge in the area of human cognitive ageing, using an innovative and interdisciplinary approach. Expected outcomes of this project include a critical understanding of the basic neural mechanisms of healthy brain ageing. This will provide significant benefits, such as the neurophysiological knowledge required to develop novel biological markers to detect, as well as therapeutic agents to curb, cognitive decline in the aging population.Read moreRead less
Understanding working memory: from cells to brain stimulation. This project aims to understand the neural mechanisms of working memory, a fundamental cognitive function in humans, using a novel framework which combines non-invasive brain stimulation, neuroimaging, pharmacological and experimental manipulations, and biological modelling. Expected outcomes include a critical understanding of the cellular mechanisms underlying both neural activity and working memory ability in healthy individuals a ....Understanding working memory: from cells to brain stimulation. This project aims to understand the neural mechanisms of working memory, a fundamental cognitive function in humans, using a novel framework which combines non-invasive brain stimulation, neuroimaging, pharmacological and experimental manipulations, and biological modelling. Expected outcomes include a critical understanding of the cellular mechanisms underlying both neural activity and working memory ability in healthy individuals and a detailed knowledge of how to non-invasively interact with these mechanisms using brain stimulation. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored approaches to reliably alter brain function and cognition.Read moreRead less
Human hippocampus subregions organisation and associative memory processes. This proposal will investigate the hippocampus, a highly inter-connected structure containing many subregions. Although considered the memory centre of the brain, we still do not know the exact roles of these subregions during memory processes. Using novel brain neuroimaging acquisition methods and analyses, this project aims to map the internal structure and functions of the hippocampus and its functional networks under ....Human hippocampus subregions organisation and associative memory processes. This proposal will investigate the hippocampus, a highly inter-connected structure containing many subregions. Although considered the memory centre of the brain, we still do not know the exact roles of these subregions during memory processes. Using novel brain neuroimaging acquisition methods and analyses, this project aims to map the internal structure and functions of the hippocampus and its functional networks under different memory conditions and how these functions change with age. The intended outcome of this proposal is to provide the foundations for the first integrated model of human memory and its biological basis and to generate a benchmark against which future development of memory interventions and retraining can be measured.Read moreRead less
Charting age-related changes in the quality of episodic memory. As we get older, our capacity to remember events in rich detail becomes less efficient. The mechanisms driving these changes remain unclear, severely limiting our capacity to accurately assess and optimise memory function in later years. This project aims to determine how memory accuracy and memory quality change across the adult lifespan using cutting-edge experimental and neuroimaging techniques. It will deliver new insights into ....Charting age-related changes in the quality of episodic memory. As we get older, our capacity to remember events in rich detail becomes less efficient. The mechanisms driving these changes remain unclear, severely limiting our capacity to accurately assess and optimise memory function in later years. This project aims to determine how memory accuracy and memory quality change across the adult lifespan using cutting-edge experimental and neuroimaging techniques. It will deliver new insights into the relationship between confidence, memory success and memory quality, and the underlying neural substrates of these processes. This work will provide the essential empirical foundation to augment memory function, ensuring that older adults can continue to participate as active members of society.Read moreRead less
Individualised predictions of circadian timing, sleep, and performance. The body's 24-hour clock regulates when we feel sleepy or alert. In shift workers, disrupted sleep and rhythms leads to fatigue and costly, often deadly, workplace accidents. Existing methods for measuring body clock timing are costly, impractical for operational settings, and do not work in real time. Using a shift-worker population, this project will develop models that accurately predict body timing, sleep/wake patterns, ....Individualised predictions of circadian timing, sleep, and performance. The body's 24-hour clock regulates when we feel sleepy or alert. In shift workers, disrupted sleep and rhythms leads to fatigue and costly, often deadly, workplace accidents. Existing methods for measuring body clock timing are costly, impractical for operational settings, and do not work in real time. Using a shift-worker population, this project will develop models that accurately predict body timing, sleep/wake patterns, and performance for an individual, requiring only a simple activity/light sensor and an assessment of the body clock's sensitivity to light. The new model would revolutionise fatigue management and make safer work environments for millions of shift workers. Read moreRead less
Neural circuitry of maternal behaviour. Elaborate maternal care is a defining characteristic of mammalian species, suggesting conserved brain pathways evolved to orchestrate these responses. The neural substrates underscoring maternal behaviour have not been fully elucidated. This project aims to investigate the brain circuitry underpinning maternal care using a multidisciplinary approach combining behavioural assays and pharmacogenetic manipulations in mice alongside sophisticated molecular and ....Neural circuitry of maternal behaviour. Elaborate maternal care is a defining characteristic of mammalian species, suggesting conserved brain pathways evolved to orchestrate these responses. The neural substrates underscoring maternal behaviour have not been fully elucidated. This project aims to investigate the brain circuitry underpinning maternal care using a multidisciplinary approach combining behavioural assays and pharmacogenetic manipulations in mice alongside sophisticated molecular and functional analyses. The outcomes of this project are expected to improve our understanding of how specific brain pathways govern maternal behaviour. The novel insight gained is expected to advance theories regarding the organisation of maternal care and enable their practical testing.Read moreRead less
Circadian photoreceptor sensitivity and impacts of modern lighting on sleep. Light has powerful non-visual effects, including effects on sleep. These non-visual effects are mediated by cells in the eye that are most sensitive to blue light. There are large individual differences in sensitivity to non-visual effects of light that are not understood and that would give great insight into suboptimal sleep, which has become widespread in modern society. This study will be the first systematic examin ....Circadian photoreceptor sensitivity and impacts of modern lighting on sleep. Light has powerful non-visual effects, including effects on sleep. These non-visual effects are mediated by cells in the eye that are most sensitive to blue light. There are large individual differences in sensitivity to non-visual effects of light that are not understood and that would give great insight into suboptimal sleep, which has become widespread in modern society. This study will be the first systematic examination of individual differences in the effect of blue light on sleep and will uncover how alterations in the gene responsible for the effects of blue light on sleep (OPN4) contribute to these differences. This will lead to scalable individualised solutions to the unmet problem of how modern light environments impact sleep.Read moreRead less
Dissecting the Brain Circuitry Shaping Fear Regulation Across Development. Adolescence is an important time when individuals learn to manage stress-related emotions like fear. This project aims to understand how maturational changes in the prefrontal cortex of the brain hinder adolescents when learning to reduce reactivity to threats. It aims to do so by dissecting the brain circuitry shaping learning, memory, and emotional regulation across pre-adolescence, adolescence, and adulthood. The proje ....Dissecting the Brain Circuitry Shaping Fear Regulation Across Development. Adolescence is an important time when individuals learn to manage stress-related emotions like fear. This project aims to understand how maturational changes in the prefrontal cortex of the brain hinder adolescents when learning to reduce reactivity to threats. It aims to do so by dissecting the brain circuitry shaping learning, memory, and emotional regulation across pre-adolescence, adolescence, and adulthood. The project expects to generate new knowledge about why developmental changes in the brain are necessary for mature forms of learning and memory. The expected outcomes of this project include a significantly richer knowledge of the developing brain, which will ultimately inform approaches for improving emotion regulation in youth.Read moreRead less
Understanding biological pathways underlying social behaviour in humans. This project aims to show for the first time how oxytocin interacts with neural social and reward pathways to guide social behaviour. Oxytocin is a natural neuropeptide and hormone that has a critical role in the regulation of social behaviour across mammalian species. In animals, direct evidence demonstrates how endogenous and exogenous oxytocin interacts with social and reward neural pathways to alter social behaviour, in ....Understanding biological pathways underlying social behaviour in humans. This project aims to show for the first time how oxytocin interacts with neural social and reward pathways to guide social behaviour. Oxytocin is a natural neuropeptide and hormone that has a critical role in the regulation of social behaviour across mammalian species. In animals, direct evidence demonstrates how endogenous and exogenous oxytocin interacts with social and reward neural pathways to alter social behaviour, including social recognition, relationship formation, and long-term bonds. The project intends to use radio-labelling techniques in combination with positron emission tomography to track oxytocin and show what regions of the brain oxytocin impacts to then influence social cognition and behaviour in humans.Read moreRead less