Force from lipids: the role of the lipid bilayer in mechanosensory transduction. The proposed research will significantly contribute to a better understanding of the wide range of physiological processes underlying mechanosensory transduction in living cells. The direct benefit for Australian science consists of: (i) strengthening international links with leading overseas laboratories, and (ii) accessing the state-of-the-art expertise not available in Australia. The acquired knowledge will aid i ....Force from lipids: the role of the lipid bilayer in mechanosensory transduction. The proposed research will significantly contribute to a better understanding of the wide range of physiological processes underlying mechanosensory transduction in living cells. The direct benefit for Australian science consists of: (i) strengthening international links with leading overseas laboratories, and (ii) accessing the state-of-the-art expertise not available in Australia. The acquired knowledge will aid in developing and designing artificial tactile sensors inspired by their biological models studied in this project. Long-term, the project is expected to make an original contribution towards developing new technologies and novel medical applications, both of which promise to be of great national benefit.Read moreRead less
Special Research Initiatives - Grant ID: SR0354636
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Australian Computational Molecular Science Network. Computational Molecular Science (CMS) involves the use of theory and computational methods to simulate and visualise molecular systems ranging from small atmospheric species to proteins, nucleic acids, chemical polymers and materials. It represents our most incisive expression of what we understand about the molecular basis of nature. The CMS network will integrate and cross-fertilize both fundamental and application-based expertize in molecula ....Australian Computational Molecular Science Network. Computational Molecular Science (CMS) involves the use of theory and computational methods to simulate and visualise molecular systems ranging from small atmospheric species to proteins, nucleic acids, chemical polymers and materials. It represents our most incisive expression of what we understand about the molecular basis of nature. The CMS network will integrate and cross-fertilize both fundamental and application-based expertize in molecular scale computations in the fields of nanoscience, biomaterials, biotechnology, biomedical science and environmental science. It will uncover and explore critical new interdisciplinary science and create new molecular-based paradigms that will drive advances in these fields over the next decade.Read moreRead less
Investigation of recognition memory in behavioural, electrophysiological, and functional neuro-imaging domains using state-trace analysis. This project utilises a novel methodology to investigate human recognition memory across three separate domains - behavioural, electrophysiological and functional neuro-imaging. The aim is to determine how these three aspects of memory are related and if they can be united by a single theory.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100192
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Deep Protein Sequencing, Structure and Quantification Facility. This project aims to establish state-of-the-art complementary mass spectrometers to help research into molecular structure and interactions, post-translational modifications, compound stability and availability within complex biological samples. The facility’s complementary mass spectrometers combine high specificity with high sensitivity and ultrafast scanning, and are expected to rapidly discover, identify and characterise biomole ....Deep Protein Sequencing, Structure and Quantification Facility. This project aims to establish state-of-the-art complementary mass spectrometers to help research into molecular structure and interactions, post-translational modifications, compound stability and availability within complex biological samples. The facility’s complementary mass spectrometers combine high specificity with high sensitivity and ultrafast scanning, and are expected to rapidly discover, identify and characterise biomolecules including peptides, proteins and small molecules. The discovery of unknown compounds is expected to improve fundamental understanding of molecular structure and function, provide opportunities for new bio-industries in health and the environment, and generate commercial opportunities through spin-off companies, patents and licensing.Read moreRead less
Harnessing the genome of the Australian paralysis tick to develop effective control products. This project aims to examine the potent cocktail produced by the salivary gland of Australia's paralysis tick. The paralysis tick continues to cause severe illness and deaths for companion pets with up to 100,000 cases of toxicoses per year. This project aims to develop new safe treatments and/or preventative vaccines.
ARC/NHMRC Research Network for Parasitology. The ARC Network for Parasitology will focus and coordinate Australia's world class fundamental, strategic and applied parasitology research. This targeted approach will raise Australia's standing in the field, assist in the community's understanding of parasitology and biosecurity and maintain and improve Australia's capacity for keeping its stock, crops, wildlife and people disease-free. On an international scale, the Network will work with other cou ....ARC/NHMRC Research Network for Parasitology. The ARC Network for Parasitology will focus and coordinate Australia's world class fundamental, strategic and applied parasitology research. This targeted approach will raise Australia's standing in the field, assist in the community's understanding of parasitology and biosecurity and maintain and improve Australia's capacity for keeping its stock, crops, wildlife and people disease-free. On an international scale, the Network will work with other countries to develop new technologies for the detection and eradication of parasites. This emphasis will not only protect Australia's borders but will assist our near neighbours and lead to the development of technologies with an economic benefit to Australia.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882854
Funder
Australian Research Council
Funding Amount
$6,000,000.00
Summary
Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shapin ....Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shaping oil and gas deposits, hydrothermal and igneous processes involved in ore genesis, and enhanced understanding of some of the world's largest earthquake- and tsunami-generating processes.
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Special Research Initiatives - Grant ID: SR120300015
Funder
Australian Research Council
Funding Amount
$16,000,000.00
Summary
The Science of Learning Research Centre. In this innovative new Centre, researchers in education, neuroscience and cognitive psychology will work together with teachers to understand the learning process. This collaboration will establish new criteria to assess the impact of different types of learning and strategies to inform teaching practices of benefit to all Australians.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100081
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Combined scanning tunnelling microscope system for materials characterisation and manipulation at nano scale. The proposed facility is unique in Australia and will substantially enhance national research capabilities in nano-materials, nanotechnology and biotechnology. The proposed infrastructure project will bring more than 20 leading Australian research groups from 10 institutions together to create an outstanding platform to underpin close collaborations among members in a broad field. The pr ....Combined scanning tunnelling microscope system for materials characterisation and manipulation at nano scale. The proposed facility is unique in Australia and will substantially enhance national research capabilities in nano-materials, nanotechnology and biotechnology. The proposed infrastructure project will bring more than 20 leading Australian research groups from 10 institutions together to create an outstanding platform to underpin close collaborations among members in a broad field. The proposed facility will provide significant benefits to Australian researchers in drug design and delivery, nano-material design and characterisation at nano scale for advanced materials, and promotion of renewable energy. This represents a great opportunity to make discoveries and breakthroughs in frontier science and technology in Australia.Read moreRead less