Structure and informatics of the genetic code. Recent advances in biotechnology have seen its emergence as a highly
quantitative, numerically-based discipline. To exploit the available
data to the full will require, alongside computing power, new
analytical techniques. This project aims to develop such techniques,
by handling the systematics of the genetic code with methods derived
from theoretical physics and chemistry. Expected outcomes include a
dynamical (quantum field theory) model ....Structure and informatics of the genetic code. Recent advances in biotechnology have seen its emergence as a highly
quantitative, numerically-based discipline. To exploit the available
data to the full will require, alongside computing power, new
analytical techniques. This project aims to develop such techniques,
by handling the systematics of the genetic code with methods derived
from theoretical physics and chemistry. Expected outcomes include a
dynamical (quantum field theory) model of phylogenetic branching,
analyses of nucleic acid structure and content (spin chain models of
RNA binding and of DNA open reading frames), and insights into the
origin of the code itself (via numerical codon similarity measures).
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Dynamics of Multiscale Complex Systems. Australia has built a strong position in the science and applications of multiscale phenomena, especially in interdisciplinary fields. The project will advance this position in plasma and biomedical physics by making new discoveries, developing new methods of analyzing such systems, and applying them to achieve practical outcomes. It will underpin Australia's participation in NASA's $600M STEREO mission, and will lead to improved methods and technologies ....Dynamics of Multiscale Complex Systems. Australia has built a strong position in the science and applications of multiscale phenomena, especially in interdisciplinary fields. The project will advance this position in plasma and biomedical physics by making new discoveries, developing new methods of analyzing such systems, and applying them to achieve practical outcomes. It will underpin Australia's participation in NASA's $600M STEREO mission, and will lead to improved methods and technologies for brain function analysis and imaging, which will be commercialized via industry partnerships. It will contribute to national research goals, especially in Breakthrough Science, Frontier Technologies, Smart Information Use, and Promoting Innovation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100186
Funder
Australian Research Council
Funding Amount
$322,054.00
Summary
Statistical mechanics and topology of polymer systems. This project aims to study the behaviour of systems of long polymers in solution, and the effects of temperature, solvent and other environmental properties. Polymer models capture important physical properties of real-world molecules like DNA. This project will study the topology of polymer chains in tightly confined spaces. Knots and links hinder important biological processes like DNA replication, and this project will research how entang ....Statistical mechanics and topology of polymer systems. This project aims to study the behaviour of systems of long polymers in solution, and the effects of temperature, solvent and other environmental properties. Polymer models capture important physical properties of real-world molecules like DNA. This project will study the topology of polymer chains in tightly confined spaces. Knots and links hinder important biological processes like DNA replication, and this project will research how entanglement forms and how the biological mechanisms are used to manage it. The project is expected to have both important biological consequences and to enhance Australia's position as a centre for research in statistical mechanics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101581
Funder
Australian Research Council
Funding Amount
$411,000.00
Summary
Stability and Complexity: New insights from Random Matrix Theory. Complexity is a rule of nature: large ecosystems, the human brain, and turbulent fluids are merely a few examples of complex systems. This project aims to study and classify criteria of stability in large complex systems based on universal probabilistic models. This project expects to generate new important understanding of stability using cutting-edge techniques from random matrix theory. Expected outcomes of this project includ ....Stability and Complexity: New insights from Random Matrix Theory. Complexity is a rule of nature: large ecosystems, the human brain, and turbulent fluids are merely a few examples of complex systems. This project aims to study and classify criteria of stability in large complex systems based on universal probabilistic models. This project expects to generate new important understanding of stability using cutting-edge techniques from random matrix theory. Expected outcomes of this project include development and expansion of an innovative mathematical framework and techniques which allow a unified and universal approach to the question of stability in large complex systems. Read moreRead less
ARC Complex Open Systems Research Network. Complexity is the common frontier in the physical, biological and social sciences. This Network will link specialists in all three sciences through five generic conceptual and mathematical theme activities. It will promote research into how subsystems self-organise into new emergent structures when assembled into an open, non-equilibrium system. Outcomes will include new technologies and software tools and deeper understanding of fundamental questions i ....ARC Complex Open Systems Research Network. Complexity is the common frontier in the physical, biological and social sciences. This Network will link specialists in all three sciences through five generic conceptual and mathematical theme activities. It will promote research into how subsystems self-organise into new emergent structures when assembled into an open, non-equilibrium system. Outcomes will include new technologies and software tools and deeper understanding of fundamental questions in science. An essential function of the network will be introducing researchers end users to new tools and broadening the horizons of graduate students.Read moreRead less
Fluctuations in the properties of nonequilibrium fluids and the influence of thermostatting mechanisms. The behaviour of nonequilibrium fluids will be studied by combining ideas from liquid state theory, statistical mechanics and dynamical systems theory. This work will result in development and testing of mathematical expressions (Fluctuation Theorems) that are consistent with the Second Law of Thermodynamics, which determines the direction of any change in any macroscopic system, but are also ....Fluctuations in the properties of nonequilibrium fluids and the influence of thermostatting mechanisms. The behaviour of nonequilibrium fluids will be studied by combining ideas from liquid state theory, statistical mechanics and dynamical systems theory. This work will result in development and testing of mathematical expressions (Fluctuation Theorems) that are consistent with the Second Law of Thermodynamics, which determines the direction of any change in any macroscopic system, but are also applicable to microscopic systems. The expressions will determine the probability that finite sized systems will violate the Second Law for small periods of time and will therefore contribute to development of a fundamental understanding of microscopic systems and the development of nanotechnology.
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Fluid properties and chaotic dynamics in equilibrium and nonequilibrium states. Over the last decade a revolution has been taking place in nonequilibrium statistical mechanics [Physics Today, Sept, 2002]. This revolution is characterized by adapting the mathematical theory of chaos to nonequilibrium statistical mechanics. Fundamental new theorems and algorithms for computing transport coefficients have been derived. The CIs have played a key role in this revolution. We seek to broaden these dev ....Fluid properties and chaotic dynamics in equilibrium and nonequilibrium states. Over the last decade a revolution has been taking place in nonequilibrium statistical mechanics [Physics Today, Sept, 2002]. This revolution is characterized by adapting the mathematical theory of chaos to nonequilibrium statistical mechanics. Fundamental new theorems and algorithms for computing transport coefficients have been derived. The CIs have played a key role in this revolution. We seek to broaden these developments by: generalizing a theorem which relates transport coefficients to chaoticity; detailed studies of the influence of thermostatting mechanisms on nonequilibrium chaoticity and fluctuations, and by understanding the range of applicability of a nonequilibrium fluctuation theorem for non-isoenergetic systems.Read moreRead less
Exact dynamics of the asymmetric exclusion process with boundaries. This project offers an opportunity for a postgraduate student to participate in world-class research. It further strengthens collaborative ties with the renowned department of theoretical physics at Oxford University. The outcomes of this project are expected to provide valuable fundamental information for any applied science in which transport plays a crucial role.
Mathematics of the quantum-classical mechanics interface. Nanotechnology focusses increasing attention on the interface between quantum and classical mechanics. Semiclassical approximations have long been studied, as a means to describe classical systems with 'small' actions as this interface is approached from the classical side. I have recently shown that classical mechanics can be formulated in complex Hilbert space, as a pseudo-quantum theory. This establishes a framework for the developme ....Mathematics of the quantum-classical mechanics interface. Nanotechnology focusses increasing attention on the interface between quantum and classical mechanics. Semiclassical approximations have long been studied, as a means to describe classical systems with 'small' actions as this interface is approached from the classical side. I have recently shown that classical mechanics can be formulated in complex Hilbert space, as a pseudo-quantum theory. This establishes a framework for the development of 'semiquantum' approximations, to enable the description of quantum systems with 'large' actions as the quantum-classical interface is approached from the quantum side. The project aims to explore some ramifications of this theoretical breakthrough.Read moreRead less
Algebraic invariants in mathematics and physics. This project is at the leading edge of fundamental mathematics and will result in important scientific advances that will keep Australia at the forefront internationally in this field of research. The topics under investigation are having high impact worldwide so there is an emphasis on international networking and on research training, particularly of research students. Australians would normally need to go to leading international centres such a ....Algebraic invariants in mathematics and physics. This project is at the leading edge of fundamental mathematics and will result in important scientific advances that will keep Australia at the forefront internationally in this field of research. The topics under investigation are having high impact worldwide so there is an emphasis on international networking and on research training, particularly of research students. Australians would normally need to go to leading international centres such as Paris to partake in projects of this nature. That high profile research of this kind can be done in Australia will enhance our capacity to retain scientific talent.Read moreRead less