Elucidating structure and function of activation-associated secreted proteins (ASPs) in blood-feeding hookworms – toward new methods of control. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links betwee ....Elucidating structure and function of activation-associated secreted proteins (ASPs) in blood-feeding hookworms – toward new methods of control. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links between basic and applied research; (3) to develop excellence in research by promoting collaborative research, resulting in a more efficient use of resources in a national and international context; (4) to enhance the skills-base in biology and biotechnology; (5) to substantially increase global visibility through quality research, leading to an increased investment in Australian science.Read moreRead less
Mitogenomics using a massively parallel reactor platform - from barcoding to diagnostic tools for pathogens of major socioeconomic importance. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links between ....Mitogenomics using a massively parallel reactor platform - from barcoding to diagnostic tools for pathogens of major socioeconomic importance. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links between basic and applied research; (3) to develop excellence in research by promoting collaborative research, resulting in a more efficient use of resources in a national and international context; (4) to enhance the skills-base in biology and biotechnology; (5) to substantially increase global visibility through quality research, leading to an increased investment in Australian science.
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Special Research Initiatives - Grant ID: SR0567460
Funder
Australian Research Council
Funding Amount
$85,000.00
Summary
Development of a collaborative environment for high throughput biology discovery pipelines. Modern biological science involves the parallel high-throughput investigation of many hundreds of different experimental targets. Traditional approaches for recording, analysing, mining and cross comparing experimental data are inadequate for conducting high throughput experiments. This proposal aims to develop new algorithms in the high throughput arena that will revolutionize biological discovery.
Infrakingdom Alveolata: searching for a defining structural feature. This project will establish the first molecular nexus between a cellular structure currently used to define an Infrakingdom of life. It will aid in the higher order systematics of our microscopic diversity and allow us to interpret how important parasites learned to penetrate host cells to establish infection. We will train excellent graduate and Honours students in cellular and molecular biology.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0231228
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Victorian Environmental Scanning Electron Microscopy Facility. The aim of this proposal is to establish a state-of-the-art Environmental Scanning Electron Microscope (ESEM) facility in the Melbourne region. ESEMs have considerable advantages over conventional instruments in that they allow imaging and analysis to be performed in gaseous or high pressure environments. This enables electron microscopy to be used for the detailed analysis of insulating, wet or out-gassing specimens in their natural ....Victorian Environmental Scanning Electron Microscopy Facility. The aim of this proposal is to establish a state-of-the-art Environmental Scanning Electron Microscope (ESEM) facility in the Melbourne region. ESEMs have considerable advantages over conventional instruments in that they allow imaging and analysis to be performed in gaseous or high pressure environments. This enables electron microscopy to be used for the detailed analysis of insulating, wet or out-gassing specimens in their natural state as well as the investigation, in real time, of dynamical processes such as crystallisation and corrosion. The new facility will support a wide range of multi-disciplinary research programs from four Universities and three CSIRO divisions.Read moreRead less
Statistical methods for detection of non-coding RNAs in eukaryote genomes. Understanding how eukaryotic cells work is a major goal of 21st century biology. A crucial step will be to catalogue the functional components of eukaryotic genomes. Australian researchers must be involved in this process at an early stage, in order to maximise commercial opportunities, attract quality researchers and position ourselves for further advances. This project will make major contributions to international effo ....Statistical methods for detection of non-coding RNAs in eukaryote genomes. Understanding how eukaryotic cells work is a major goal of 21st century biology. A crucial step will be to catalogue the functional components of eukaryotic genomes. Australian researchers must be involved in this process at an early stage, in order to maximise commercial opportunities, attract quality researchers and position ourselves for further advances. This project will make major contributions to international efforts in this area, via the development of statistical methods for segmenting genomes, classification of those segments, and study of the resulting classes. In the long term, enhanced understanding of eukaryotic cells will lead to breakthroughs in biology, and to medical, pharmaceutical, agricultural and scientific advances.Read moreRead less
ARC Centre of Excellence - Coherent X-ray Science. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This Centre draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membra ....ARC Centre of Excellence - Coherent X-ray Science. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This Centre draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membrane protein. We will develop techniques based on the latest developments in theoretical physics & chemistry, imaging, biology and technology - including the new Australian Synchrotron - to create new approaches to structural biology.Read moreRead less
Testing the free radical theory of aging: do indicators of oxidative damage predict lifespan? Because of the Free Radical Theory of Aging, many millions of dollars are spent around the world on dietary antioxidants of unproven efficacy. Many millions of research dollars are spent providing support for this theory but few studies test it rigorously. The first major benefit of this research is worldwide; to refute, or to substantially enhance and focus the current support for the Free Radical Theo ....Testing the free radical theory of aging: do indicators of oxidative damage predict lifespan? Because of the Free Radical Theory of Aging, many millions of dollars are spent around the world on dietary antioxidants of unproven efficacy. Many millions of research dollars are spent providing support for this theory but few studies test it rigorously. The first major benefit of this research is worldwide; to refute, or to substantially enhance and focus the current support for the Free Radical Theory. This should help to rationalise and direct funding supplied to these areas. The second benefit is for Australia: aging is a fruitful area for research because of the high general public interest and for training because of its multidisciplinary nature, and funding in Australia is very low by international standards. Read moreRead less
Evaluation of the EG95 vaccine against hydatid infection in macropodid marsupials. A parasitic infection known as hydatids was introduced into Australia by Europeans and is now causing mortality in Australian wallabies and kangaroos, including amongst endangered species. A vaccine against the disease, that was developed in Australia for use in domestic livestock, is being evaluated to determine if it could be used to prevent hydatids closely monitored populations of endangered macropod marsupia ....Evaluation of the EG95 vaccine against hydatid infection in macropodid marsupials. A parasitic infection known as hydatids was introduced into Australia by Europeans and is now causing mortality in Australian wallabies and kangaroos, including amongst endangered species. A vaccine against the disease, that was developed in Australia for use in domestic livestock, is being evaluated to determine if it could be used to prevent hydatids closely monitored populations of endangered macropod marsupials, such as Petrogale penicillata.Read moreRead less
Mathematical modelling in developmental biology. Modern observational techniques in biology and medicine generate a wealth of genetic and molecular detail. Mathematical modelling integrates and synthesises this information to provide insight into how complex biological processes are coupled to produce experimentally observed behaviour. Mathematical modelling generates experimentally testable predictions that can be used to verify the validity of the models. This program is dedicated to exciting ....Mathematical modelling in developmental biology. Modern observational techniques in biology and medicine generate a wealth of genetic and molecular detail. Mathematical modelling integrates and synthesises this information to provide insight into how complex biological processes are coupled to produce experimentally observed behaviour. Mathematical modelling generates experimentally testable predictions that can be used to verify the validity of the models. This program is dedicated to exciting opportunities for advancing our knowledge of normal and abnormal developmental processes, especially in embryonic growth. Understanding these processes will lead to prediction and treatment of congenital disorders and contribute to a healthy start to life. Read moreRead less