Intelligent training (iTraining) for the human Achilles tendon. The project aims to improve understanding of the mechanical environment of the Achilles tendon. The Achilles tendon plays a crucial role in human motor function and is also a structure that is commonly injured and notoriously difficult to treat. A major barrier to improving Achilles tendon function, preventing tendon injury and enhancing tendon repair is a poor understanding of the mechanical environment of the Achilles tendon durin ....Intelligent training (iTraining) for the human Achilles tendon. The project aims to improve understanding of the mechanical environment of the Achilles tendon. The Achilles tendon plays a crucial role in human motor function and is also a structure that is commonly injured and notoriously difficult to treat. A major barrier to improving Achilles tendon function, preventing tendon injury and enhancing tendon repair is a poor understanding of the mechanical environment of the Achilles tendon during training and rehabilitation. The project aims to develop a better understanding of the loading conditions that optimise tendon metabolism. Based on this, it then intends to develop new technologies to estimate the mechanical behaviour of the human Achilles tendon in real time based on integrated use of wearable technology, and new training guidelines that will optimise human tendon adaptation.Read moreRead less
Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of ....Targeting the undruggable: epitope mapping using Phylomers peptides to modulate activity of Transcription Factors. This project aims at expanding the pool of drug targets, by extending drug screening to protein-protein interaction networks. This project aims to assemble a novel technical platform to detect binding between proteins, using a combination of cell-free protein expression, AlphaScreen and single-molecule fluorescence. This pipeline has great potential to accelerate the exploration of protein networks, and provides also a generic platform for drug screening on difficult targets. The project intends to screen Phylogica's libraries of peptides called Phylomers to discover tight binders to a Transcription Factor, Sox18. The objective of this project is to determine which Phylomers can disrupt specific interactions between Sox18 and its binding partners involved in lymphangiogenesis.Read moreRead less
A microfluidic array of phylomers for rapid discovery of peptide probes and biomarkers. This project, through an alliance with Phylogica, aims at exploiting a unique source of structural diversity for drug discovery, harvesting the creativity of nature in its most exotic places. The project will develop a novel approach to validate design and validate drug candidates, by gathering them on a single screening chip for a powerful discovery platform.
Barriers for cost - effective rock fall hazard mitigation. Rock fall barriers are used throughout Australia to protect its extensive road and rail networks. These networks are vital links in the nation's infrastructure and underpin its economic prosperity and development. There are thousands of cuttings on Australia' transport networks, many of which have the potential to be affected by rock falls. These events can take lives and severely disrupt the performance of our transport infrastructure. ....Barriers for cost - effective rock fall hazard mitigation. Rock fall barriers are used throughout Australia to protect its extensive road and rail networks. These networks are vital links in the nation's infrastructure and underpin its economic prosperity and development. There are thousands of cuttings on Australia' transport networks, many of which have the potential to be affected by rock falls. These events can take lives and severely disrupt the performance of our transport infrastructure. This project will develop new cost-effective methods for designing against rock fall events using a combination of advanced testing and computer modelling.Read moreRead less
Securing Australian floating wind developments with helical anchors. This project will reduce the cost of offshore floating wind energy by uniting leading academic expertise and innovative industry partners to develop the knowledge and practical tools that will enable the deployment of helical anchors as a cheap and reliable anchoring system for floating wind. Helical anchors are seen as the most promising solution to anchor wind turbines, but their deployment has been limited by uncertainties a ....Securing Australian floating wind developments with helical anchors. This project will reduce the cost of offshore floating wind energy by uniting leading academic expertise and innovative industry partners to develop the knowledge and practical tools that will enable the deployment of helical anchors as a cheap and reliable anchoring system for floating wind. Helical anchors are seen as the most promising solution to anchor wind turbines, but their deployment has been limited by uncertainties associated with the torque and vertical force required for installation in complex seabeds, and their performance under environmental loading. The project will address these specific points through a combination of physical, numerical and analytical modelling, using data and design scenarios provided by industry.
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Vaporization of heavier gas oil in Fluid Catalytic Cracking risers. Fluid Catalytic Cracking (FCC) is an important refinery operation responsible for about 45 per cent of the total petrol produced. The project is aimed at improving production efficiency of Australian refineries by applying fundamental modelling to the FCC. The outcomes will enable refiners to produce cleaner fuel and decrease greenhouse gas emissions.
Assessment of structural integrity and deterioration of masonry walls. Brickwork for housing and medium-rise buildings is a traditional material, also much used for modern construction, with aesthetic appeal and modest cost. However, building regulators and others are increasingly concerned about evidence of slow building deterioration, particularly of older buildings. This increases public safety risks, even under normal conditions and more so under high winds or earthquake-induced ground-shaki ....Assessment of structural integrity and deterioration of masonry walls. Brickwork for housing and medium-rise buildings is a traditional material, also much used for modern construction, with aesthetic appeal and modest cost. However, building regulators and others are increasingly concerned about evidence of slow building deterioration, particularly of older buildings. This increases public safety risks, even under normal conditions and more so under high winds or earthquake-induced ground-shaking. This project will help address this issue. It will obtain unbiased evidence of typical masonry building deterioration. It will couple this with mathematical modelling and state-of-the-art non-destructive visual and dynamic techniques to develop tools for making fast, low-cost practical building risk assessments.Read moreRead less
Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization ....Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization tools and numerical models. The final outcome of the project will be a set of designs of the columns, which should be more efficient, safer and cheaper to operate, and have smaller physical and environmental footprints, thus helping the Australian LNG industry to stay globally competitive.Read moreRead less
In-situ Characterisation of Coal from Coal Seam Gas Developments. We aim to develop advanced methods for determination of coal properties required for optimising gas recovery, scheduling future developments and water management by Queensland Gas Company. We will characterise multiphase flow of gas and water in coal cores by Positron Emission Tomography and flooding experiments. Advancement in knowledge is achieved by using massive data from 4D-imaging to predict evolution of petrophysical proper ....In-situ Characterisation of Coal from Coal Seam Gas Developments. We aim to develop advanced methods for determination of coal properties required for optimising gas recovery, scheduling future developments and water management by Queensland Gas Company. We will characterise multiphase flow of gas and water in coal cores by Positron Emission Tomography and flooding experiments. Advancement in knowledge is achieved by using massive data from 4D-imaging to predict evolution of petrophysical properties at in situ condition in different types of coal. This will future proof Australia as the world’s largest exporter of natural gas and will provide significant benefit for the industry in satisfying domestic gas security, maintaining international commitment and addressing environmental concerns. Read moreRead less
Efficiently unlocking full-scale WEC dynamics for industry cost reduction. This project will reduce the cost of ocean wave energy, by uniting leading expertise from academia with cutting-edge know-how and full-scale data from industry to advance the way oceanic forces on wave energy converters are represented in industry models. These models are critical for designing and controlling the next generation of wave energy converters, which have larger motions than ever before. Carefully tested model ....Efficiently unlocking full-scale WEC dynamics for industry cost reduction. This project will reduce the cost of ocean wave energy, by uniting leading expertise from academia with cutting-edge know-how and full-scale data from industry to advance the way oceanic forces on wave energy converters are represented in industry models. These models are critical for designing and controlling the next generation of wave energy converters, which have larger motions than ever before. Carefully tested models will lead to better estimates of power production and loads, which will drive down the cost of wave energy and enable its large-scale utilisation. Broad communication of benefits and sharing of new knowledge will accelerate commercialisation of ocean energy in Australia and pave the way to meeting our future energy needs.Read moreRead less