Tissue Engineering of Human Heart Valve Grown In Vitro. Tissue engineering (TE) of heart valves is a new approach to cultivate a functional heart valve from human autologous cells. This innovative study aims to develop the technology to transplant cells onto a 3D biocompatible valve scaffold that is capable of mimicking native valve. The work proposed is a ground breaking study that will encompass development of a new biomaterial, manufacture of scaffolds using the Fused Deposition Modelling ra ....Tissue Engineering of Human Heart Valve Grown In Vitro. Tissue engineering (TE) of heart valves is a new approach to cultivate a functional heart valve from human autologous cells. This innovative study aims to develop the technology to transplant cells onto a 3D biocompatible valve scaffold that is capable of mimicking native valve. The work proposed is a ground breaking study that will encompass development of a new biomaterial, manufacture of scaffolds using the Fused Deposition Modelling rapid prototyping process, hemodynamic optimisation and in vitro cell culture. This will advance our knowledge in cellular and scaffold technologies and may ultimately lead to the development of a TE heart valve.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989384
Funder
Australian Research Council
Funding Amount
$233,000.00
Summary
High-speed, three-dimensional, x-ray fluoroscopy for accurate measurement of human joint motion. This proposal addresses one of the most difficult and long-standing problems in the field of biomechanics: How can human joint motion be measured accurately and non-invasively during common activities such as walking, stair ambulation and running? Low-dose, high-speed, three-dimensional, x-ray fluoroscopy provides an excellent solution to this problem and, in so doing, can play a pivotal role in heal ....High-speed, three-dimensional, x-ray fluoroscopy for accurate measurement of human joint motion. This proposal addresses one of the most difficult and long-standing problems in the field of biomechanics: How can human joint motion be measured accurately and non-invasively during common activities such as walking, stair ambulation and running? Low-dose, high-speed, three-dimensional, x-ray fluoroscopy provides an excellent solution to this problem and, in so doing, can play a pivotal role in healthcare, through clinical gait analysis and gait rehabilitation (diagnosis, prevention and treatment of movement disorders); in sports, through the development of personalized training programs for elite athletes; and in entertainment, through the creation of physics-based animations for the video/digital games industry.Read moreRead less
Fluid dynamics and mechanical stress of tissue heart valves. Major problems with thrombo-embolic complications and leaflet failure and calcification still exist with bioprosthetic valves. Valves fabricated from polyether urethanes are efficient and can offer more resistance to calcification. No complete study on the haemodynamics and structure interactions is found in literature. Moreover, todate the effect of aortic wall motion on the blood flow has never been examined. A complete holistic ap ....Fluid dynamics and mechanical stress of tissue heart valves. Major problems with thrombo-embolic complications and leaflet failure and calcification still exist with bioprosthetic valves. Valves fabricated from polyether urethanes are efficient and can offer more resistance to calcification. No complete study on the haemodynamics and structure interactions is found in literature. Moreover, todate the effect of aortic wall motion on the blood flow has never been examined. A complete holistic approach to simulataneuosly simulating the fluid dynamics, the valve motion and the stress in a synthetic Polyether urethane valve is proposed. Cell adhesion study will also be carried out. The findings may yield to new insights into valve research.Read moreRead less
Characterization and optimisation of Myomatrix: A novel extracellular matrix hydrogel from muscle. This project would have several sources of benefit for the community. Foremost we will have produced a product that will have a strong commercial application in several fields including basic science and bioengineering. If its full potential were achieved, the development of this innovative new hydrogel would strengthen Australia's standing in the biotechnology field and also enrich specific applic ....Characterization and optimisation of Myomatrix: A novel extracellular matrix hydrogel from muscle. This project would have several sources of benefit for the community. Foremost we will have produced a product that will have a strong commercial application in several fields including basic science and bioengineering. If its full potential were achieved, the development of this innovative new hydrogel would strengthen Australia's standing in the biotechnology field and also enrich specific applications. The knowledge gained from the characterization of this product could also be of benefit to several areas including chemical engineering, tissue engineering, tissue repair, polymer chemistry and food manufacture. The expertise generated and the possibility of collaboration, both academic and with industry would also benefit the community. Read moreRead less
Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric ....Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric oxide regulates large artery stiffness and we believe that other endothelial mediators are also important regulators. Therefore, we aim to explore this in a series of studies. Regulation of stiffness of large arteries will improve treatment of age-related cardiovascular disease (eg isolated systolic hypertension)Read moreRead less
Response of residential structures to blast vibration. This proposed project combines the expertise and disciplines of residential construction, structural dynamics and blasting technology. The ultimate aim of the project is to develop a rational methodology for assessing the damage potential of ground vibration resulting from blasting on typical Australian residential structures. The project involves field blast vibration measurements, static and dynamic laboratory tests on structural sub-assem ....Response of residential structures to blast vibration. This proposed project combines the expertise and disciplines of residential construction, structural dynamics and blasting technology. The ultimate aim of the project is to develop a rational methodology for assessing the damage potential of ground vibration resulting from blasting on typical Australian residential structures. The project involves field blast vibration measurements, static and dynamic laboratory tests on structural sub-assemblages in a controlled environment, and comprehensive analytical modelling of both loading and response. The outcomes from this research will have direct application to the mining, insurance, construction and defence industries.Read moreRead less
Microstructure-Based Computational Homogenization of Geomaterials. This project seeks to establish a basis for virtual testing of materials. This type of non-destructive testing has numerous applications of obvious benefit to society and will contribute to the continued growth and development of a large number of industries in Australia and worldwide. The methods developed will allow for cheaper, faster, and more accurate testing of materials. The outcomes of the project can find direct applicat ....Microstructure-Based Computational Homogenization of Geomaterials. This project seeks to establish a basis for virtual testing of materials. This type of non-destructive testing has numerous applications of obvious benefit to society and will contribute to the continued growth and development of a large number of industries in Australia and worldwide. The methods developed will allow for cheaper, faster, and more accurate testing of materials. The outcomes of the project can find direct application in civil engineering as well as in environmental, mining and petroleum engineering which together make up a significant portion of the nation's industry.Read moreRead less
Thin-walled Structures Subjected to Impact and Blast Loading. Terrorist attacks have cost Australians much human grief and billions of dollars. Containing the consequences of a blast or impact is crucial to survival and restricting damage to critical civilian/defence infrastructure. Thin-walled structures are used extensively in such infrastructure. There is a lack of knowledge about their behaviour when subjected to impulse and blast loads. The investigators will establish the most economical m ....Thin-walled Structures Subjected to Impact and Blast Loading. Terrorist attacks have cost Australians much human grief and billions of dollars. Containing the consequences of a blast or impact is crucial to survival and restricting damage to critical civilian/defence infrastructure. Thin-walled structures are used extensively in such infrastructure. There is a lack of knowledge about their behaviour when subjected to impulse and blast loads. The investigators will establish the most economical means of designing passive blast protection into thin-walled structures and hence, Australia's critical infrastructure. This knowledge will be transferred into design standards and Australia's limited defence resources.Read moreRead less
A Mechanistic Approach to the Compression Properties of Z-Pinned Composites. The proposed research is a fundamental investigation of the compressive mechanical properties and failure mechanisms of fibre reinforced polymer (FRP) composites reinforced with z-pins. These composites are a new material with strong potential applications in aerospace structures subject to high compressive loads, however their compressive properties are poorly understood. Using theoretical modelling, finite element an ....A Mechanistic Approach to the Compression Properties of Z-Pinned Composites. The proposed research is a fundamental investigation of the compressive mechanical properties and failure mechanisms of fibre reinforced polymer (FRP) composites reinforced with z-pins. These composites are a new material with strong potential applications in aerospace structures subject to high compressive loads, however their compressive properties are poorly understood. Using theoretical modelling, finite element analysis and experimentation, the research program will greatly enhance the fundamental understanding of the strengthening and failure mechanisms of z-pinned composites. A key outcome of the research will be design guidelines for optimising the pinning of composites for maximum structural performance in aerospace applications.Read moreRead less
Role of Reactive Particles in Explosive Emulsions. Concentrated water-in oil explosive emulsions are widely used in the minerals industry because they are cheap, easily detonated and relatively safe to handle. Their explosive energy can be significantly increased when reactive particles are introduced into the emulsion matrix. To do this, the interaction between the solid, oil, and water phases needs to be optimised. This investigation will increase our basic understanding of the physical and ch ....Role of Reactive Particles in Explosive Emulsions. Concentrated water-in oil explosive emulsions are widely used in the minerals industry because they are cheap, easily detonated and relatively safe to handle. Their explosive energy can be significantly increased when reactive particles are introduced into the emulsion matrix. To do this, the interaction between the solid, oil, and water phases needs to be optimised. This investigation will increase our basic understanding of the physical and chemical interactions that occur between the particle and the oil-water interface, and develop a more efficient explosive that can be produced continuously on a commercial scale.Read moreRead less