Discovery Early Career Researcher Award - Grant ID: DE120102352
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Three-dimensional structural imaging in optical microscopy and tomography. This project will develop fundamentally new strategies for looking inside live cells to determine their internal structures. Such capability will permit a better understanding of diseases, the link between diabetes and heart failure for example, opening the door for new diagnostic techniques and treatments.
Imaging the invisible. This project aims to develop imaging technology to see and quantify objects normally invisible with X-rays. It will develop an X-ray imaging system that should provide orders of magnitude greater sensitivity to subtle changes in material composition than conventional radiography. It will devise quantitative image analysis tools for isolating specific materials of interest from complex multi-material samples, including low density components that often go undetected. Indust ....Imaging the invisible. This project aims to develop imaging technology to see and quantify objects normally invisible with X-rays. It will develop an X-ray imaging system that should provide orders of magnitude greater sensitivity to subtle changes in material composition than conventional radiography. It will devise quantitative image analysis tools for isolating specific materials of interest from complex multi-material samples, including low density components that often go undetected. Industries that could benefit significantly from this technology include airport security, the mining sector, agriculture, manufacturing quality control, and biomedical researchers studying anatomical form and function.Read moreRead less
Non-destructing X-ray testing. This project aims to improve imaging with X-rays, providing better image quality with higher throughput at a lower radiation dose. It will develop an X-ray imaging system that provides orders of magnitude greater sensitivity for detecting low-density objects that are often invisible with conventional X-ray scanners, and quantitative image analysis tools that can isolate materials from complex multi-material samples and detect individual chemical elements. Significa ....Non-destructing X-ray testing. This project aims to improve imaging with X-rays, providing better image quality with higher throughput at a lower radiation dose. It will develop an X-ray imaging system that provides orders of magnitude greater sensitivity for detecting low-density objects that are often invisible with conventional X-ray scanners, and quantitative image analysis tools that can isolate materials from complex multi-material samples and detect individual chemical elements. Significant benefits from these technologies are expected in industries including airport security, mining, agriculture, manufacturing quality control, and in research fields from medicine to geology.Read moreRead less
Functional nonlinear optical endoscopy - the third-generation optical endoscopy technology toward early cancer detection at a cellular level. The third-generation optical endoscopy technology can be used for a better understanding of nonlinear optical interaction with organ sites and thus for early cancer detection. Such a novel device will enable biomedical scientists to gain the fundamental knowledge needed to enable Australians to develop better medical strategies for health and productive li ....Functional nonlinear optical endoscopy - the third-generation optical endoscopy technology toward early cancer detection at a cellular level. The third-generation optical endoscopy technology can be used for a better understanding of nonlinear optical interaction with organ sites and thus for early cancer detection. Such a novel device will enable biomedical scientists to gain the fundamental knowledge needed to enable Australians to develop better medical strategies for health and productive lives. Since 1 in 3 Australians will feel the effects of cancers, development of portable nonlinear optical endoscopes is of national importance, in particular for rural Australia, and therefore improves the healthcare of human beings. The potential spin-off activity will lead to economic benefits from new R&D development.Read moreRead less
Dynamic multi-modal x-ray imaging. This project aims to create sensitive new methods of x-ray imaging that capture multiple image modalities with a single snapshot. Conventional x-ray imaging is widely used in a range of industries, but captures only a fraction of the rich information that is available in the x-ray wavefield. This project expects to extract additional image modalities to reveal x-ray-transparent features, and detect microscopic textures. By combining these capabilities with the ....Dynamic multi-modal x-ray imaging. This project aims to create sensitive new methods of x-ray imaging that capture multiple image modalities with a single snapshot. Conventional x-ray imaging is widely used in a range of industries, but captures only a fraction of the rich information that is available in the x-ray wavefield. This project expects to extract additional image modalities to reveal x-ray-transparent features, and detect microscopic textures. By combining these capabilities with the ability to capture images of a moving sample, this project will enable innovative biomedical and materials research studies, and develop new imaging technologies for use in security, hospitals and manufacturing. New methods of x-ray imaging will have wide-ranging benefits for society, the economy and healthcare.Read moreRead less
Ultrafast Photonic Electron Microscopy: Visualising dynamics at the nanoscale. The dynamics of molecular processes are too fast to observe with any microscope so science has instead relied on recording the static before and after states of these changes, inferring what happens in between. This project aims to combine the advantages of ultrafast photonic laser control and electron microscopy to allow the direct visualisation of dynamics at the nanoscale in physical and biological systems. By prov ....Ultrafast Photonic Electron Microscopy: Visualising dynamics at the nanoscale. The dynamics of molecular processes are too fast to observe with any microscope so science has instead relied on recording the static before and after states of these changes, inferring what happens in between. This project aims to combine the advantages of ultrafast photonic laser control and electron microscopy to allow the direct visualisation of dynamics at the nanoscale in physical and biological systems. By providing a view into how order emerges from the thermal chaos of molecular objects this project aims to help to reveal the physical basis for life.Read moreRead less
Optical Fibre Touch Sensor for Cochlear Implants. The touch sensor will be part of a cochlear implant, which is surgically implanted to provide a sense of hearing for people who are profoundly or severely deaf. Approximately 100,000 people worldwide have received cochlear implants so far. However, the delicate internal structures of the ear can easily be damaged when the implant is inserted. By helping surgeons to preserve the inner ear, this sensor will help to further improve the hearing abili ....Optical Fibre Touch Sensor for Cochlear Implants. The touch sensor will be part of a cochlear implant, which is surgically implanted to provide a sense of hearing for people who are profoundly or severely deaf. Approximately 100,000 people worldwide have received cochlear implants so far. However, the delicate internal structures of the ear can easily be damaged when the implant is inserted. By helping surgeons to preserve the inner ear, this sensor will help to further improve the hearing ability of future patients. The 'bionic ear' was invented in Australia and this project will help to ensure the continued success of Australia's world leading implant industry.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101504
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Nano-resolution hard x-ray diffraction imaging with conventional laboratory sources. The project will combine advanced optics and algorithms for diffraction imaging to develop a desktop hard x-ray microscope. The system will display ultra-high resolution and will be highly complementary to electronic and optical microscopies for diverse applications in materials engineering, nanofluidics and cell biology.