Quantitative multi-modal optical imaging of deep tissue. This project aims to create new tools to quantify the structural and functional properties of tissue. Combining multiple optical imaging technologies (multi-modal) into a single, miniaturised probe, these tools could enable physiologists and biomedical researchers to obtain new insight into disease. Encasing the highly miniaturised probe within a medical needle is aimed to allow insertion of the 'needle probe' deep into tissue, extending o ....Quantitative multi-modal optical imaging of deep tissue. This project aims to create new tools to quantify the structural and functional properties of tissue. Combining multiple optical imaging technologies (multi-modal) into a single, miniaturised probe, these tools could enable physiologists and biomedical researchers to obtain new insight into disease. Encasing the highly miniaturised probe within a medical needle is aimed to allow insertion of the 'needle probe' deep into tissue, extending optical imaging to areas not previously accessible. The project could develop novel quantification models to allow longitudinal assessment and comparison between subjects. Validating the tools with specific biomarkers, it could provide outcomes in breast and liver cancer, and a framework to explore other diseases.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100078
Funder
Australian Research Council
Funding Amount
$190,000.00
Summary
An advanced multimodal terahertz spectroscopy and imaging system for WA. An advanced multimodal terahertz spectroscopy and imaging system: Terahertz (THz) technology is in use in diverse applications from semiconductor inspection, metamaterials, biology and protein analysis, pharmaceutical sciences and formulations; security and surveillance, and biomedical imaging for burn assessment and cancer detection. This project will provide researchers with access to state-of-the-art THz spectroscopy and ....An advanced multimodal terahertz spectroscopy and imaging system for WA. An advanced multimodal terahertz spectroscopy and imaging system: Terahertz (THz) technology is in use in diverse applications from semiconductor inspection, metamaterials, biology and protein analysis, pharmaceutical sciences and formulations; security and surveillance, and biomedical imaging for burn assessment and cancer detection. This project will provide researchers with access to state-of-the-art THz spectroscopy and imaging facilities, resulting in high-impact outcomes across the physical and biological sciences and engineering, broadly contributing to Australia's economic and social well being.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100057
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
A high-resolution X-ray microtomography system. This project aims to establish a Scanco microCT 50 high resolution X-Ray microtomography system, to non-destructively visualise and quantitatively characterise complex samples, including advanced composites, tissue engineering constructs, biological tissues, minerals and fossils. The non-destructive characterisation of these samples is critical to advance research. The versatile system offers high spatial resolution (down to 500 nm voxel size) and ....A high-resolution X-ray microtomography system. This project aims to establish a Scanco microCT 50 high resolution X-Ray microtomography system, to non-destructively visualise and quantitatively characterise complex samples, including advanced composites, tissue engineering constructs, biological tissues, minerals and fossils. The non-destructive characterisation of these samples is critical to advance research. The versatile system offers high spatial resolution (down to 500 nm voxel size) and large sample size (up to 100 mm diameter). The project will enable progress in advanced composites, additive bio-manufacturing, physiology of biological tissues and palaeontology which will benefit Australian science. Additionally, through commercialisation and the formation of new companies, the project could potentially result in economic and health benefits to the wider Australian population and economy.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC180100024
Funder
Australian Research Council
Funding Amount
$4,000,000.00
Summary
ARC Training Centre for Medical Implant Technologies. The ARC Training Centre for Medical Implant Technologies aims to train a new generation of interdisciplinary engineers and to transform the orthopaedic and maxillofacial implant industry in Australia. In collaboration with industry, universities and hospitals, the Centre will build a dynamic training environment for interdisciplinary engineers to develop and evaluate personalised implants and surgeries. It will create new networks, internatio ....ARC Training Centre for Medical Implant Technologies. The ARC Training Centre for Medical Implant Technologies aims to train a new generation of interdisciplinary engineers and to transform the orthopaedic and maxillofacial implant industry in Australia. In collaboration with industry, universities and hospitals, the Centre will build a dynamic training environment for interdisciplinary engineers to develop and evaluate personalised implants and surgeries. It will create new networks, international collaborations and a generation of industry-ready researchers critical for growing Australia’s industry. The advances in materials and savings in time for procedures will reduce costs.
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Combined Terahertz Imaging and Optical Coherence Tomography. This project aims to exploit the synergies between terahertz imaging and optical coherence tomography. These novel imaging modalities will be combined into a single multi-modality technique which will have application in numerous industry sectors like manufacturing, non-destructive testing, pharmaceutical and medicine. The intended outcome of the project is to create an internationally leading position for Australia in cutting-edge res ....Combined Terahertz Imaging and Optical Coherence Tomography. This project aims to exploit the synergies between terahertz imaging and optical coherence tomography. These novel imaging modalities will be combined into a single multi-modality technique which will have application in numerous industry sectors like manufacturing, non-destructive testing, pharmaceutical and medicine. The intended outcome of the project is to create an internationally leading position for Australia in cutting-edge research in optical and terahertz imaging. This innovative, fundamental research will expand Australia’s research capacity in imaging with wide ranging applications. The anticipated goal of the project is to build a prototype imaging system with industry partners ready for the next step to commercialisation. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668435
Funder
Australian Research Council
Funding Amount
$1,300,000.00
Summary
Biomedical Engineering Sensing and Imaging Facility. The sensing and imaging facility will be the only national facility for leading engineering and medical researchers to undertake multidiscipline research into live and model biological systems. The facility will capture and combine existing strengths in these fields in Melbourne. This will provide new insights into the physiology of human, animal and plant systems and the development of preventive and curative strategies for disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100009
Funder
Australian Research Council
Funding Amount
$1,064,000.00
Summary
Ultra-high resolution magnetic resonance imaging (MRI) system for physical applications. Ultra-high resolution magnetic resonance imaging (MRI) system for physical applications: Ultra-high field magnetic resonance imaging provides unique high contrast images at previously inaccessible levels of resolution (<0.1mm). It non-invasively provides unprecedented information on chemical and biochemical processes including functional biological mechanisms. This infrastructure will be the focal point for ....Ultra-high resolution magnetic resonance imaging (MRI) system for physical applications. Ultra-high resolution magnetic resonance imaging (MRI) system for physical applications: Ultra-high field magnetic resonance imaging provides unique high contrast images at previously inaccessible levels of resolution (<0.1mm). It non-invasively provides unprecedented information on chemical and biochemical processes including functional biological mechanisms. This infrastructure will be the focal point for more than 100 academics and HDR students. It will take Australia to the forefront of magnetic resonance imaging capability as well as providing unique insights into diffusion and electrophoretic problems central to designing next generation energy storage. Outcomes will range from agricultural advances, higher performing batteries, and more effective cancer treatments as well advancing Australia's fundamental scientific capabilities.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less