Discovery Early Career Researcher Award - Grant ID: DE220100302
Funder
Australian Research Council
Funding Amount
$461,300.00
Summary
A long-lasting interface for communicating with the brain. This project aims to address the most urgent challenges in developing the next generation of implantable devices for communicating with the brain. Using a new type of carbon-based electrode, along with light therapy, this project expects to build innovative technologies that can greatly enhance the functionality and longevity of these devices. Expected outcomes include a novel tool that can be implemented to obtain detailed insights into ....A long-lasting interface for communicating with the brain. This project aims to address the most urgent challenges in developing the next generation of implantable devices for communicating with the brain. Using a new type of carbon-based electrode, along with light therapy, this project expects to build innovative technologies that can greatly enhance the functionality and longevity of these devices. Expected outcomes include a novel tool that can be implemented to obtain detailed insights into neural circuits, advancing our understanding of neural function and pioneering feedback and closed-loop neuroscience. This project should provide significant benefits in neuroscience research and the neural interface industry, both of which have the ultimate goal to unlock the mysteries of the brain.Read moreRead less
Novel Targeted PEG Nanoparticles For Cancer Treatment And Monitoring
Funder
National Health and Medical Research Council
Funding Amount
$606,979.00
Summary
We will develop novel targeted cancer therapies based on next generation nanoparticles. These particles will deliver highly potent drugs to tumours with less adverse effects to healthy organs. The ability to image the therapeutic can be used to detect diseases at early, potentially curable stages, identify patients likely to respond to certain treatments, and predict response to therapy. Our project has the potential to increase the survival of patients suffering from the most deadly cancer.
Nanomedicines Immunotargeting: Hitting The Target Or Lost In Translation ?
Funder
National Health and Medical Research Council
Funding Amount
$413,042.00
Summary
Nanomedicines are some of the most exciting novel approaches to improving the way we detect, manage and treat cancers. This cross-disciplinary project aims to provide a rigorous understanding of how nanomedicines penetrate solid tumour tissues. To validate in vitro tumour model developed in the project, in vivo studies will be carried out in a mice model. The penetration and distribution of nanomedicines inside tumour tissues after intravenous administration will be determined.
Bacterial detection and infection control using tethered membranes. This project will develop a rapid diagnostic tool to detect live bacteria, which will subsequently reduce risk of infection, increase efficiencies in patient care and hospital management, and produce savings in health care budgets. It also has the potential to save lives through addressing the serious and growing problem of antibiotic resistance.
Harnessing the bioactivity of proteins and polypeptides: understanding and controlling adsorption processes to optimise linker free immobilisation. This project will use physical techniques and simulations to understand the interactions of biomolecules and plasma activated surfaces, allowing control of the biomolecule layer composition, orientation and conformation. This control, together with the ability of these surfaces to "lock-in" the optimised layer, will create a new generation of biodevi ....Harnessing the bioactivity of proteins and polypeptides: understanding and controlling adsorption processes to optimise linker free immobilisation. This project will use physical techniques and simulations to understand the interactions of biomolecules and plasma activated surfaces, allowing control of the biomolecule layer composition, orientation and conformation. This control, together with the ability of these surfaces to "lock-in" the optimised layer, will create a new generation of biodevices.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100900
Funder
Australian Research Council
Funding Amount
$366,000.00
Summary
Smart aptamer-guided nanoexosome as a novel biotechnology platform. This project aims to develop guided novel nanomaterials as a new biotechnological platform for in vivo targeted delivery of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) for gene editing. By systematically engineering the surface properties of natural nanovesicles known as exosomes, a novel nanotechnology platform should be established. The guided nano biotechnological platform should not only enable targete ....Smart aptamer-guided nanoexosome as a novel biotechnology platform. This project aims to develop guided novel nanomaterials as a new biotechnological platform for in vivo targeted delivery of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) for gene editing. By systematically engineering the surface properties of natural nanovesicles known as exosomes, a novel nanotechnology platform should be established. The guided nano biotechnological platform should not only enable targeted in vivo precision gene editing via CRISPR but also specific delivery of gene editing machinery across the blood brain barrier for better exploration of fundamental biology of the brain.Read moreRead less
Biofabricated tissue mimics for nanoparticle design and development. Nanoparticles are widely used in commercial applications spanning biotechnology, health and environmental monitoring, and drug delivery. Materials scientists can generate large libraries of nanoparticles, but the toolbox available to test these nanoparticles is limited. We will use biofabrication to comprehensively evaluate the fate of polymer grafted nanocellulose across simulated tissue barriers. Model blood vessels with reci ....Biofabricated tissue mimics for nanoparticle design and development. Nanoparticles are widely used in commercial applications spanning biotechnology, health and environmental monitoring, and drug delivery. Materials scientists can generate large libraries of nanoparticles, but the toolbox available to test these nanoparticles is limited. We will use biofabrication to comprehensively evaluate the fate of polymer grafted nanocellulose across simulated tissue barriers. Model blood vessels with recirculating flow will help understand permeation; tunable matrices will establish ‘matrix structure—nanoparticle diffusion’ criteria. The outcome from this project will be an understanding of how plastic nanoparticles penetrate tissue, to guide nanomaterials design and mitigate risk associated with toxicity. Read moreRead less
Ultrathin Gold Nanocrystal Conductors for Wearable Epidermal Biofuel Cells. This project aims to fabricate ultrathin, soft yet stretchable gold nanocrystal conductors to push the thickness limit of next-generation soft bioelectrodes for fabrication of wearable epidermal biofuel cells. This will generate new knowledge and patentable technologies related to design/fabrication of soft nanocrystal conductors, bioanode and biocathode, which require to be thin, soft, conductive and biocompatible. Expe ....Ultrathin Gold Nanocrystal Conductors for Wearable Epidermal Biofuel Cells. This project aims to fabricate ultrathin, soft yet stretchable gold nanocrystal conductors to push the thickness limit of next-generation soft bioelectrodes for fabrication of wearable epidermal biofuel cells. This will generate new knowledge and patentable technologies related to design/fabrication of soft nanocrystal conductors, bioanode and biocathode, which require to be thin, soft, conductive and biocompatible. Expected outcomes of this project include enhanced national capacity in disruptive wearable bioelectronics, strengthening international collaborations, unskilled workforce training, as well as advancement of Australian knowledge base in the fields of nanotechnology, materials science, energy, biosensors and bioelectronics.Read moreRead less
Engineering layered double hydroxide nanoparticles toward an efficient targeted clinical delivery system. This project will develop a more effective drug delivery system using clay nanoparticles and biofriendly serum proteins. Outcomes from this project will provide a tremendous opportunity for potent therapies of cancers, vasculature and neuronal diseases, and place Australia at the forefront of nanotechnology drug delivery research.
Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineerin ....Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineering.Read moreRead less