Properties of nanomaterials determine their disposal by liver cells. This project aims to understand how the liver handles and is affected by nanomaterials in the body. Nanomaterials are widely used in industrial, environmental, consumer and drug products, but how they affect human health is poorly understood. This project will characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using chemistry, imaging and biological method ....Properties of nanomaterials determine their disposal by liver cells. This project aims to understand how the liver handles and is affected by nanomaterials in the body. Nanomaterials are widely used in industrial, environmental, consumer and drug products, but how they affect human health is poorly understood. This project will characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using chemistry, imaging and biological methods. This work is expected to determine how nanomaterials’ attributes direct pathways for liver cell disposal and describe nanomaterial–liver interactions at the cellular level, information crucial in enabling safer nanomaterials for use in products such as drug formulations, sunscreens and cosmetics.Read moreRead less
Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The ....Modelling applications of nanomaterials in biology and medicine. This proposal will address fundamental issues related to nanomaterials and their applications in biology and medicine. Accurate mathematical models will be formulated, leading to new practical techniques in nanobiotechnology, safe and effective methods to diagnose and cure diseases including cancer via targeted drug and gene delivery, and detection methods for biological hazards, such as those arising from biological terrorism. The research facility proposed involves significant training of applied mathematicians at honours, PhD and postdoctoral levels and multidisciplinary collaboration, ensuring that Australia maintains and develops an expertise in nanobiotechnology well into the future.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100223
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
Advanced in-situ electron microscope facility for research in alloys, nanomaterials, functional materials, magnetic materials and minerals. This advanced in situ electron microscope facility will provide Australia with a new and critical capability to understand and design technologically important materials. It will enable advances in the areas of energy, environment, transport, construction and mining.