Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools ....A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools and the imaging platform will have applications for researchers wishing to visualise small and rapid molecular events in four dimensions (length, width, height and across time) under fluid shear stress, which is applicable across a range of industries. The project expects to deliver the next generation of intravital microscopes that can visualise and quantify events in a challenging flow environment.Read moreRead less
5D Imaging Flow Cytometry for in vivo Quantification of Biological Fluids. Rapid and accurate quantification of live biological fluid properties at sub-cellular and molecular levels forms the bedrock of biofluidic sciences. Majority of the biofluidic devices rely on quantifying biological fluids after its removal from the body in an in vitro Flow Cytometer (FC). FC faces many caveats i.e. biological degradation and small volume etc. In this project, we shall engineer the first in vivo 5D imaging ....5D Imaging Flow Cytometry for in vivo Quantification of Biological Fluids. Rapid and accurate quantification of live biological fluid properties at sub-cellular and molecular levels forms the bedrock of biofluidic sciences. Majority of the biofluidic devices rely on quantifying biological fluids after its removal from the body in an in vitro Flow Cytometer (FC). FC faces many caveats i.e. biological degradation and small volume etc. In this project, we shall engineer the first in vivo 5D imaging flow cytometer (5D IFC) capable of continuous assessment of potentially entire blood volume in a living mice without removing fluid out of the body. The project represents a major advancement beyond any existing flow cytometer and overcome the engineering limits of state-of-art laser scanning imaging devices.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560716
Funder
Australian Research Council
Funding Amount
$864,610.00
Summary
A National T-ray Facility. T-rays are between microwaves and infrared on the electromagnetic spectrum. Recently, advances in femtosecond lasers enabled access to T-ray frequencies, producing an important new imaging modality for non-invasive sensing of materials and structures. Internationally, T-rays represent a rich new science leading to advanced forms of biophotonics, biomedical imaging and spectroscopy. Non-invasive T-ray diagnostics of nano- and bio-materials are being hotly pursued. The o ....A National T-ray Facility. T-rays are between microwaves and infrared on the electromagnetic spectrum. Recently, advances in femtosecond lasers enabled access to T-ray frequencies, producing an important new imaging modality for non-invasive sensing of materials and structures. Internationally, T-rays represent a rich new science leading to advanced forms of biophotonics, biomedical imaging and spectroscopy. Non-invasive T-ray diagnostics of nano- and bio-materials are being hotly pursued. The outcome will be a strategically important Australian T-ray facility that will provide immediate and transparent nationwide access. Historically, industry is transformed every time a new part of the electromagnetic spectrum becomes accessible - T-rays are the next frontier.Read moreRead less
Special Research Initiatives - Grant ID: SR0354517
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Adaptive Optics for Australian Astronomy, Medicine, Industry, and Defence. Adaptive optics is a technique for correcting wavefront distortions in light beams to improve optical imaging performance. The Research Network for Adaptive Optics aims to draw together isolated Australian and New Zealand research groups working on adaptive optics applications in disparate areas to achieve a critical mass of researchers in this burgeoning field. Adaptive optics has wide application in areas as diverse as ....Adaptive Optics for Australian Astronomy, Medicine, Industry, and Defence. Adaptive optics is a technique for correcting wavefront distortions in light beams to improve optical imaging performance. The Research Network for Adaptive Optics aims to draw together isolated Australian and New Zealand research groups working on adaptive optics applications in disparate areas to achieve a critical mass of researchers in this burgeoning field. Adaptive optics has wide application in areas as diverse as astronomy, vision science, ophthalmology, microscopy, optical communications, laser radar, and laser beam shaping. The Research Network will coordinate and expand Australian involvement in these areas and inform industry, as have similar networks in the USA and Europe.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100009
Funder
Australian Research Council
Funding Amount
$455,000.00
Summary
Ultra-precision cutting and polishing machines for fabricating high-Q crystalline resonators. The proposed facility will equip Australian researchers with the capability to machine and polish optical crystalline materials down to atomic-level smoothness. The availability of this technology will enable the fabrication of ultra-sensitive metrological sensors, state-of-the-art photonic components, and quantum devices. Precision metrology is an integral component of many industries and it underpins ....Ultra-precision cutting and polishing machines for fabricating high-Q crystalline resonators. The proposed facility will equip Australian researchers with the capability to machine and polish optical crystalline materials down to atomic-level smoothness. The availability of this technology will enable the fabrication of ultra-sensitive metrological sensors, state-of-the-art photonic components, and quantum devices. Precision metrology is an integral component of many industries and it underpins a modern, technically advanced society. With this facility Australian researchers will lead the world in the fabrication of optical crystalline devices for a broad range of industrial and research applications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100164
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
GNOSIS: a new window on the early universe using revolutionary photonic technology. Australian astronomers have a long history in innovative instrumentation and are some of the early pioneers in infrared astronomy. The GNOSIS project brings together leading Australian astronomers to build on past success. This facility instrument makes use of recent technological advances in photonics—a key strength of Australian research and industry—to provide a dramatic improvement in observational sensitivit ....GNOSIS: a new window on the early universe using revolutionary photonic technology. Australian astronomers have a long history in innovative instrumentation and are some of the early pioneers in infrared astronomy. The GNOSIS project brings together leading Australian astronomers to build on past success. This facility instrument makes use of recent technological advances in photonics—a key strength of Australian research and industry—to provide a dramatic improvement in observational sensitivity at these wavelengths. This will allow Australian astronomers to carry out new science programmes that have not been possible to date. These programmes include unprecedented observations of very cool low mass stars, the first chemical information on dust-embedded star clusters, and accurate ages for distant galaxies.Read moreRead less