Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
Development of an implantable blood flow and pressure monitor for pulmonary hypertension. The aim is to develop an implantable device for continuous measurement of blood pressure and flow rate in the pulmonary artery. The device is to store data and download it on request to an external device. Development steps include design of the sensor lead incorporating impedance electrodes and a pressure transducer, numerical modelling of the electrode system, characterising pressure and flow waveforms f ....Development of an implantable blood flow and pressure monitor for pulmonary hypertension. The aim is to develop an implantable device for continuous measurement of blood pressure and flow rate in the pulmonary artery. The device is to store data and download it on request to an external device. Development steps include design of the sensor lead incorporating impedance electrodes and a pressure transducer, numerical modelling of the electrode system, characterising pressure and flow waveforms for condensed storage, establishing flow sensor and blood flow relationships and assessment of sensor stability and calibration demands. The device will facilitate research in pulmonary hypertension and may lead to clinical devices for monitoring effectiveness of treatment.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
New separation technologies for profiling metabolites in biological samples. Metabolomics is an important new field of science that is contributing to the understanding of life processes at the molecular level. But a widely acknowledged major limitation of current metabolomics technologies is the inability to accurately identify high numbers of detected metabolites in the biological extracts being studied. This project will develop cutting-edge separation science approaches to address this exist ....New separation technologies for profiling metabolites in biological samples. Metabolomics is an important new field of science that is contributing to the understanding of life processes at the molecular level. But a widely acknowledged major limitation of current metabolomics technologies is the inability to accurately identify high numbers of detected metabolites in the biological extracts being studied. This project will develop cutting-edge separation science approaches to address this existing problem in metabolomics analysis. In doing so it will provide enormous benefit to Australian biotechnology and biomedical research and play a major role in transferring capabilities to laboratories and research institutes that are involved in research aimed at elucidating biological pathways and networks.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.
Radio Interferometer Studies of Compact Astronomical Sources. The giant black holes in the centres of distant galaxies that are the topic of this study are used to set the reference frame for geodesy on the earth. Remote and exotic as they are, they have real-world applications such as improving the positions available from GPS receivers and measuring continental drift. The signal processing equipment being developed for this new telescope is based on FPGA (field programmable gate array) chips ....Radio Interferometer Studies of Compact Astronomical Sources. The giant black holes in the centres of distant galaxies that are the topic of this study are used to set the reference frame for geodesy on the earth. Remote and exotic as they are, they have real-world applications such as improving the positions available from GPS receivers and measuring continental drift. The signal processing equipment being developed for this new telescope is based on FPGA (field programmable gate array) chips, that promise to revolutionize the data processing industry, from radar to cellular telephones to computer networks. The young scientists who are working on this project will go on to lead the commercial and industrial applications of this new technology.Read moreRead less
Novel approach to study mechanisms of Na+ transport in plants using Lab on a Chip technology. A Lab on a Chip for sodium ion measurements in plants is proposed, offering a long overdue solution to the lack of appropriate techniques to study the mechanisms of sodium iron uptake, transport and compartmentation. Sodium ion transport is a key determinant of salt tolerance, but a good understanding of its transport mechanisms is lacking since no appropriate measurement tools are available. Using the ....Novel approach to study mechanisms of Na+ transport in plants using Lab on a Chip technology. A Lab on a Chip for sodium ion measurements in plants is proposed, offering a long overdue solution to the lack of appropriate techniques to study the mechanisms of sodium iron uptake, transport and compartmentation. Sodium ion transport is a key determinant of salt tolerance, but a good understanding of its transport mechanisms is lacking since no appropriate measurement tools are available. Using the system proposed here, sodium ion is separated from interfering ions, allowing fast and selective measurements. A series of ground breaking studies towards sodium ion uptake, transport and compartmentation in plants will be conducted using this Lab on a Chip.Read moreRead less
ARC Centre of Excellence - Australian Centre for Electromaterials Science. The Centre will tackle some of the biggest challenges facing society: those of renewable energy, sustainable industries and enhancing human health. Improvements in all these areas are possible by developing electromaterials with improved efficiency in the generation and transfer of electrical charge. By developing new nano-materials and new theories to explain their behaviour, the Centre will make advances in the areas ....ARC Centre of Excellence - Australian Centre for Electromaterials Science. The Centre will tackle some of the biggest challenges facing society: those of renewable energy, sustainable industries and enhancing human health. Improvements in all these areas are possible by developing electromaterials with improved efficiency in the generation and transfer of electrical charge. By developing new nano-materials and new theories to explain their behaviour, the Centre will make advances in the areas of human health through the regeneration of damaged nerves (eg. in spinal injury) and development of artificial muscles; in renewable energy (plastic solar cells, lightweight batteries and electronic textiles) and in sustainable industries (recovery of precious metals and new corrosion protection technologies).Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560868
Funder
Australian Research Council
Funding Amount
$552,475.00
Summary
SHRIMP SI - Microscale stable-isotope analysis in the Earth Sciences. Stable-isotope variations of elements such as oxygen, carbon, and sulphur, preserve the most profound records of environmental conditions during the geological, biological, and climatic evolution of Earth and planets. We will build a stable isotope ion microprobe (SHRIMP SI) to examine extraterrestrial and terrestrial systems in unprecedented detail. In terrestrial applications, the main issue is accuracy at the 0.01 percent ....SHRIMP SI - Microscale stable-isotope analysis in the Earth Sciences. Stable-isotope variations of elements such as oxygen, carbon, and sulphur, preserve the most profound records of environmental conditions during the geological, biological, and climatic evolution of Earth and planets. We will build a stable isotope ion microprobe (SHRIMP SI) to examine extraterrestrial and terrestrial systems in unprecedented detail. In terrestrial applications, the main issue is accuracy at the 0.01 percent level for 20-micron spots, which we can apply to studies of development of life on Earth, climatic records, weathering, and formation of ore bodies. Sample return missions of solar wind and comets will provide unique samples related to the formation of our solar system.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100201
Funder
Australian Research Council
Funding Amount
$530,000.00
Summary
A major upgrade to the Australia Telescope Compact Array. This project aims to upgrade the $150m CSIRO Australia Telescope Compact Array ("the telescope"), by replacing the signal processing electronics and doubling the bandwidth. This will significantly enhance the performance of the telescope, enabling more ambitious science by the 450 researchers and students who use it each year. For example, it will enable the telescope to study radio counterparts to Gravitational Wave sources, and it will ....A major upgrade to the Australia Telescope Compact Array. This project aims to upgrade the $150m CSIRO Australia Telescope Compact Array ("the telescope"), by replacing the signal processing electronics and doubling the bandwidth. This will significantly enhance the performance of the telescope, enabling more ambitious science by the 450 researchers and students who use it each year. For example, it will enable the telescope to study radio counterparts to Gravitational Wave sources, and it will enable it to make detailed observations of initial discoveries made with the Australian Square Kilometre Array Pathfinder and other Australian telescopes. In short, it will enable Australian researchers to do more ambitious research, and make more discoveries, across broad areas of astrophysics.Read moreRead less