Understanding the mechanisms of GABA type-A receptor activation and drug modulation. There is currently little understanding of how sedative and anxiolytic drugs, including valium, interact with their receptors in the brain. This project will dramatically increase our understanding of how these receptors work and how drugs affect their activity. This will provide new insights into drug discovery and design.
Activation mechanisms of Cys-loop ion channel receptors. This proposal will employ a cutting edge approach to reveal fundamental new insights into the ways that proteins work. The information and technology developed here will broaden and strengthen Australia's research expertise across a number of basic scientific disciplines. The results will also have relevance to human health. Cys-loop ligand-gated receptors have an essential role in brain function and are targets for many therapies and drug ....Activation mechanisms of Cys-loop ion channel receptors. This proposal will employ a cutting edge approach to reveal fundamental new insights into the ways that proteins work. The information and technology developed here will broaden and strengthen Australia's research expertise across a number of basic scientific disciplines. The results will also have relevance to human health. Cys-loop ligand-gated receptors have an essential role in brain function and are targets for many therapies and drugs of abuse. New insights into how biological ligands and drugs affect ion channel structure and function may lead to novel therapeutic opportunities and improved drug structure predictions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101175
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Ultra-fast functional magnetic resonance imaging (fMRI) mapping of layer-specific interhemispheric plasticity. The goal of this project is to apply a cutting edge functional magnetic resonance imaging (fMRI) method to study the link between plasticity and its neural circuit substrates. This project will determine how plasticity between the two hemispheres of the brain is mediated via the connecting fibre tract known as the corpus callosum.