Electron and Positron Interactions with Bio-Molecules. This program of research will quantify reaction rates and elucidate reaction pathways for a range of important processes in our bodies involving ionising radiation. It will lead to a greatly improved understanding of positron and electron interactions with biological systems, including DNA and its constituent molecules and, through a better understanding of the underlying fundamental interactions, will lay foundations for improvements in te ....Electron and Positron Interactions with Bio-Molecules. This program of research will quantify reaction rates and elucidate reaction pathways for a range of important processes in our bodies involving ionising radiation. It will lead to a greatly improved understanding of positron and electron interactions with biological systems, including DNA and its constituent molecules and, through a better understanding of the underlying fundamental interactions, will lay foundations for improvements in technologies such as PET imaging. Read moreRead less
Universal quantum imaging. This project will integrate quantum technology with the rapidly advancing techniques of spatial light modulation utilised in LCD displays and video projectors. We will develop, for the first time, broadly versatile imaging technology based on quantum mechanics, enabling both important applications in future medical diagnostic devices and communication systems; and fundamental advances in the biological and quantum sciences. Quantum technologies offer the promise to rev ....Universal quantum imaging. This project will integrate quantum technology with the rapidly advancing techniques of spatial light modulation utilised in LCD displays and video projectors. We will develop, for the first time, broadly versatile imaging technology based on quantum mechanics, enabling both important applications in future medical diagnostic devices and communication systems; and fundamental advances in the biological and quantum sciences. Quantum technologies offer the promise to revolutionise many aspects of modern life, from computing and communications, to medical imaging and metrology. This project will put Australia at the international forefront of quantum imaging, enhancing Australia's already significant international presence in the area.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989648
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Optical test-bed facility for mid infrared components for sensing, imaging and astrophotonics. This test facility will enable Australian researchers to validate optical components and technologies at wavelengths from 2.5 to 20 microns, that are crucial for a wide range of applications including biophotonics, sensing, imaging, defense, and astro-photonics. Technologies related to the Mid IR are
expected to have a significant impact on quality of life and global economy. It will enable Australi ....Optical test-bed facility for mid infrared components for sensing, imaging and astrophotonics. This test facility will enable Australian researchers to validate optical components and technologies at wavelengths from 2.5 to 20 microns, that are crucial for a wide range of applications including biophotonics, sensing, imaging, defense, and astro-photonics. Technologies related to the Mid IR are
expected to have a significant impact on quality of life and global economy. It will enable Australian researchers to achieve a major impact in many areas of Mid IR fundamental and applied science as well as industry sectors such as sensing, biophotonics, defence, health, bio-security and imaging. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882289
Funder
Australian Research Council
Funding Amount
$520,000.00
Summary
New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, ( ....New generation mass spectrometers for characterisation of molecular shape and size. The ion mobility mass spectrometer (IMMS at UOW) will be the first of its kind in Australia, and together with the ion trap mass spectrometer (ITMS at ANU) will continue the tradition of this partnership in providing researchers with cutting-edge instrumentation for nationally and internationally important projects including: (i) fundamental understanding of the ways in which biomolecules recognize one another, (ii) investigating the structure(s) of lipids (fats) in cardiovascular disease and cataract, (iii) developing anticancer drugs, and (iv) development of new materials.Read moreRead less
Auger-electron yields of medical radioisotopes. Large numbers of Auger electrons are emitted during the decay of many medical isotopes. Auger electrons have a short range and a strong ability to break chemical bonds. However no measurements of the number of Auger electrons per nuclear decay exist in the critical low energy regime. Calculated Auger yields are incomplete and inconsistent. Building on unique Australian expertise and instrumentation, and performing both calculations and measurements ....Auger-electron yields of medical radioisotopes. Large numbers of Auger electrons are emitted during the decay of many medical isotopes. Auger electrons have a short range and a strong ability to break chemical bonds. However no measurements of the number of Auger electrons per nuclear decay exist in the critical low energy regime. Calculated Auger yields are incomplete and inconsistent. Building on unique Australian expertise and instrumentation, and performing both calculations and measurements, his project aims to determine the number of Auger electrons per nuclear decay accurately for medical isotopes. The outcome will be accurate dose data for radioisotopes, plus essential knowledge to develop new cancer treatments based on Auger electrons, which target a fraction of a cell.Read moreRead less
ARC Centre of Excellence - Coherent X-ray Science. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This Centre draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membra ....ARC Centre of Excellence - Coherent X-ray Science. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This Centre draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membrane protein. We will develop techniques based on the latest developments in theoretical physics & chemistry, imaging, biology and technology - including the new Australian Synchrotron - to create new approaches to structural biology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.
Positrons in biosystems. This project aims to improve our understanding of the damage processes in Positron Emission Tomography (PET). PET is a widely used medical imaging technique, but there are gaps in our understanding of the underlying interactions, in particular in the case of the radiation damage induced during the process. By using new models incorporating accurate descriptions of interactions processes, verified by experimental measurement, this project will develop a new model of posit ....Positrons in biosystems. This project aims to improve our understanding of the damage processes in Positron Emission Tomography (PET). PET is a widely used medical imaging technique, but there are gaps in our understanding of the underlying interactions, in particular in the case of the radiation damage induced during the process. By using new models incorporating accurate descriptions of interactions processes, verified by experimental measurement, this project will develop a new model of positron transport in PET. The project will allow validation of predictions from the model by undertaking experiments in liquid water.Read moreRead less
Intermolecular interactions revisited-Flaws in the fabric and applications to lower-dimensional structures. This project aims to capitalise on recent developments, that have shown that previously accepted theories are deeply flawed, in various applications in fundamental physics and in unsolved problems in biology that involve electromagnetic fields. Interactions driven
by electromagnetic fluctuation forces, and real photon exchange, between molecules will be investigated. The project will inv ....Intermolecular interactions revisited-Flaws in the fabric and applications to lower-dimensional structures. This project aims to capitalise on recent developments, that have shown that previously accepted theories are deeply flawed, in various applications in fundamental physics and in unsolved problems in biology that involve electromagnetic fields. Interactions driven
by electromagnetic fluctuation forces, and real photon exchange, between molecules will be investigated. The project will investigate how dispersion interactions change in mesoscopic pores, in electrolytes, and at finite temperatures. Applications involve
catalysis, molecular formation, and quantum logic. The project also aims to develop a unified theory for energy and charge transfer, relevant for photosynthesis and the way biological molecules transfer information.Read moreRead less
Macromolecular Condensates: From Globules to Toroids and Beyond. Polymers are long-chain molecules which are vital for all living things. Examples include proteins and DNA which carries all of the information needed for life. In the cell and in the laboratory these polymers are often found in a compact folded state. Current polymer science is good at describing very flexible polymers, but fails to describe most biological polymers which have backbones that are difficult to bend. Our aim is to ....Macromolecular Condensates: From Globules to Toroids and Beyond. Polymers are long-chain molecules which are vital for all living things. Examples include proteins and DNA which carries all of the information needed for life. In the cell and in the laboratory these polymers are often found in a compact folded state. Current polymer science is good at describing very flexible polymers, but fails to describe most biological polymers which have backbones that are difficult to bend. Our aim is to describe the folded or globular state for many kinds of biological polymers and thus improve our understanding of the role of polymers in living things.Read moreRead less