Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour ....Supercritical-microfluidics technology for targeted delivery to the colon. This research will develop nanosystems to target delivery of drugs to the colon. Our nanosystems will permit the combination of clinically used chemotherapy drugs within a single dosage form. This will improve the efficiency of delivery to the colon while reducing unwanted side-effects. A novel supercritical microfluidics system will be developed to produce therapeutic nano-carriers in a continuous mode with lower labour requirement, higher production rate and better quality control than conventional production methods. The new process will combine benefits from both supercritical fluid technology (green process) and microfluidics (high mass & heat transfer).Read moreRead less
Linking topology and rheology for designing supramolecular polymer networks. This project aims to develop a foundation for understanding how microscopic topology and intermolecular interactions control the flow behaviour of supramolecular polymer networks. Brownian dynamics algorithms will be developed to unravel the complex dynamics of the network and calibrated by comparison with carefully designed experiments. The expected outcome of the project is a quantitative framework for connecting the ....Linking topology and rheology for designing supramolecular polymer networks. This project aims to develop a foundation for understanding how microscopic topology and intermolecular interactions control the flow behaviour of supramolecular polymer networks. Brownian dynamics algorithms will be developed to unravel the complex dynamics of the network and calibrated by comparison with carefully designed experiments. The expected outcome of the project is a quantitative framework for connecting the molecular structure and energy landscape with resulting macroscopic properties. This project should yield significant benefit in the rational design of supramolecular systems in which the thermorheological properties can be tuned over a wide range of force/time scales with applications spanning from enhanced oil recovery to injectable hydrogels.Read moreRead less
Optical fibre photoreactor for removing airborne molecular contaminants and volatile organic carbons for semiconductor fabrication and fuel cell applications. The collaboration integrates concepts from photocatalysis, optical fibre technology and filtration, to solve important issues in the semiconductor fabrication and fuel cell industries. The project will place Australia amongst the world-leaders in novel integrated photocatalytic/filtration techniques and provide significant opportunities fo ....Optical fibre photoreactor for removing airborne molecular contaminants and volatile organic carbons for semiconductor fabrication and fuel cell applications. The collaboration integrates concepts from photocatalysis, optical fibre technology and filtration, to solve important issues in the semiconductor fabrication and fuel cell industries. The project will place Australia amongst the world-leaders in novel integrated photocatalytic/filtration techniques and provide significant opportunities for penetration, in particular, into the US filtration market. The collaboration will afford young Australian-based researchers the opportunity to access technology, expertise and knowledge developed in the US, which is currently unavailable in Australia. It will strengthen ties between UNSW and UMN and provide opportunities for further collaboration.Read moreRead less
Benign fabrication of microfluidic hydrogel for improved artificial vasculature in bone implants. We will create a benign technology for synthesising microfluidic hydrogels to generate artificial vascultures in bone implants. It is a critical step to enable the use of tissue-engineered vital organs, such as bone, heart and kidney in patients with end-stage organ failure. Thicker scaffolds will be possible, as the vasculature will provide nutrients and oxygen for cells to grow into 3D scaffolds. ....Benign fabrication of microfluidic hydrogel for improved artificial vasculature in bone implants. We will create a benign technology for synthesising microfluidic hydrogels to generate artificial vascultures in bone implants. It is a critical step to enable the use of tissue-engineered vital organs, such as bone, heart and kidney in patients with end-stage organ failure. Thicker scaffolds will be possible, as the vasculature will provide nutrients and oxygen for cells to grow into 3D scaffolds. It will promote capacity of Australia for manufacturing global biomaterial products for tissue engineering. We will also develop in-situ imaging analytical protocols for the rapid analysis of broad arrays of functional molecules, with significant bearing on BioMEMS design to develop methods for diagnosis of fatal diseases.Read moreRead less
Special Research Initiatives - Grant ID: SR180200046
Funder
Australian Research Council
Funding Amount
$758,233.00
Summary
Plasma Bubble Column for one step remediation of PFAS. This project aims to develop a new class of plasma water treatment reactors by combining the effectiveness of atmospheric air plasma with the effective mixing of bubble columns. Non-thermal plasmas have been demonstrated to degrade PFAS at the laboratory scale, but key questions remain on the mechanisms of action and process scaling. This project brings together expertise on plasma engineering, bubble column reactors, modelling and industria ....Plasma Bubble Column for one step remediation of PFAS. This project aims to develop a new class of plasma water treatment reactors by combining the effectiveness of atmospheric air plasma with the effective mixing of bubble columns. Non-thermal plasmas have been demonstrated to degrade PFAS at the laboratory scale, but key questions remain on the mechanisms of action and process scaling. This project brings together expertise on plasma engineering, bubble column reactors, modelling and industrial scaling to address these issues. The expected outcomes of this project are the development and demonstration of a modular, re-deployable plasma bubble column reactor for the one step destruction of PFAS. The benefits of this project are a new low cost method to remediate PFAS contamination.Read moreRead less
Optical tweezers as a micro-rheological probe of soft surfaces. Biomembranes are more than soft containers - their dynamic flexibility plays an important role in cell function, but measurements of mechanical properties of soft surfaces are non-existent. This project develops and applies a new optical tweezers method to measure the flexibility of membranes and its effects upon the friction of nearby particles.
Engineering the next generation of scaffolds. Engineering the next generation of scaffolds. This project aims to develop high efficiency quantum dots based on carbon nanomaterials, integrated with scaffolds and viable tissue cells, which can be used to develop smart implants with monitoring capabilities to reduce patient trauma and expenses. In certain cases, more than 50% of medical implants fail. Improving effective intervention is urgently needed, particularly monitoring of implants and early ....Engineering the next generation of scaffolds. Engineering the next generation of scaffolds. This project aims to develop high efficiency quantum dots based on carbon nanomaterials, integrated with scaffolds and viable tissue cells, which can be used to develop smart implants with monitoring capabilities to reduce patient trauma and expenses. In certain cases, more than 50% of medical implants fail. Improving effective intervention is urgently needed, particularly monitoring of implants and early diagnosis to prevent rejections and adverse reactions. Current methods are inefficient, expensive, and induce toxicity. A non-toxic and non-invasive method to monitor the progress of tissue regeneration and wound healing is expected to place Australia at the forefront of developing implants.Read moreRead less
University of Queensland/Arizona State University partnership to design industrially suitable zeolite membranes for desalination. For desalination, the highest costs are organic-based membrane replacement (lasting ~1 year) and energy requirement. Functionalised zeolitic membranes are low-cost, high performing, chemically tolerant and thermally stable. New zeolite membranes in principle could perform the separation outlasting their organic counterparts, while at the same time offering major energ ....University of Queensland/Arizona State University partnership to design industrially suitable zeolite membranes for desalination. For desalination, the highest costs are organic-based membrane replacement (lasting ~1 year) and energy requirement. Functionalised zeolitic membranes are low-cost, high performing, chemically tolerant and thermally stable. New zeolite membranes in principle could perform the separation outlasting their organic counterparts, while at the same time offering major energy reductions from higher fluxes. Current zeolite membrane research for desalination however is lacking. The proposed team offers experience in bringing highly significant lab scale technologies to industrial scales. The outcomes will address mutual priorities between Australia and USA for reliable low cost supply of fresh water.Read moreRead less
Unlocking Australia's offshore gas endowment. This project aims to develop practical new methods of predicting and detecting the formation of solids in gas and liquefied natural gas (LNG) production. Australia has large offshore reserves of natural gas and has made the investments necessary to help fuel the global transition to cleaner, reliable energy sources. However, conventional engineering approaches of producing gas from deep-water reserves have reached the limits of viability because of t ....Unlocking Australia's offshore gas endowment. This project aims to develop practical new methods of predicting and detecting the formation of solids in gas and liquefied natural gas (LNG) production. Australia has large offshore reserves of natural gas and has made the investments necessary to help fuel the global transition to cleaner, reliable energy sources. However, conventional engineering approaches of producing gas from deep-water reserves have reached the limits of viability because of the costs required to prevent solids forming in subsea pipelines or cryogenic LNG plants. The project’s expected outcome include sophisticated tools in open-access software based on these new predictive methods, and a step-change in Australia’s ability to access its offshore gas.Read moreRead less
Adsorption and Removal of Trace Organic Compounds by Membrane Processes used in Water Treatment and Wastewater Recycling. Recycling of municipal wastewaters is of growing importance as a resource-conservation and environmental-protection measure in Australia. A major impediment to increased rates of water recycling is a lack of knowledge regarding the presence, fate and removal of key trace organic compounds. Among these key contaminants are pharmaceutically active compounds (PhACs) and steroid ....Adsorption and Removal of Trace Organic Compounds by Membrane Processes used in Water Treatment and Wastewater Recycling. Recycling of municipal wastewaters is of growing importance as a resource-conservation and environmental-protection measure in Australia. A major impediment to increased rates of water recycling is a lack of knowledge regarding the presence, fate and removal of key trace organic compounds. Among these key contaminants are pharmaceutically active compounds (PhACs) and steroid hormones. This research will lead to a thorough understanding of the mechanisms involved with the removal of these compounds by membrane treatment applications. Major benefits will be enhanced ability to undertake risk management and a lowering of costs associated with full-scale water treatment applications.Read moreRead less