Development of planar patch-clamp electrophysiology to investigate liposome-based artificial nanosensor devices. This project aims to characterise the interaction of transport proteins with unsupported lipid bilayer membranes. This will provide the basis for a novel biosensor utilising mechanosensitive ion channels incorporated into an artificial lipid bilayer membrane. To support this outcome, the project will develop the planar patch-clamp electrophysiology recording techniques suitable for l ....Development of planar patch-clamp electrophysiology to investigate liposome-based artificial nanosensor devices. This project aims to characterise the interaction of transport proteins with unsupported lipid bilayer membranes. This will provide the basis for a novel biosensor utilising mechanosensitive ion channels incorporated into an artificial lipid bilayer membrane. To support this outcome, the project will develop the planar patch-clamp electrophysiology recording techniques suitable for liposomes. This provides a significant PhD training opportunity and brings an international focus to the development of planar patch-clamp electrophysiology in Australia. The project has significant commercial potential by developing both the planar patch-clamp electrophysiology techniques for liposomes and producing a novel biomimetic mechanosensitive biosensor.Read moreRead less
Opto-Microfluidics: A Rapid and Sensitive Platform for Biological Diagnostics. One in four people above 25 years suffer from diabetes-related diseases in Australia, with an associated economic cost exceeding $3 billion a year. A microdevice for continuous glucose monitoring would help patients to manage the disease, leading to huge individual, clinical and societal benefits. Life expectancy is expected to increase along with quality of life. Integration of the microdevice with insulin delivery w ....Opto-Microfluidics: A Rapid and Sensitive Platform for Biological Diagnostics. One in four people above 25 years suffer from diabetes-related diseases in Australia, with an associated economic cost exceeding $3 billion a year. A microdevice for continuous glucose monitoring would help patients to manage the disease, leading to huge individual, clinical and societal benefits. Life expectancy is expected to increase along with quality of life. Integration of the microdevice with insulin delivery would realise an 'artificial pancreas', revolutionising the management and treatment of the disease. The technology will also provide a platform for other point-of-care medical diagnostic devices, which will allow early participation in this emerging market and cement Australia's position in bionanotechnology.Read moreRead less
Ultra-sensitivity through resonances in photonic bandgap fibres. The project will develop innovative biochemical sensors with extreme sensitivity using recently discovered physical processes in novel holey optical fibres. These sensors will be able to detect biological molecules, toxins or dangerous chemicals in minute concentrations, in very small sample sizes. The sensors can be mass-produced cheaply with current fabrication facilities within Australia, enabling their widespread use for water ....Ultra-sensitivity through resonances in photonic bandgap fibres. The project will develop innovative biochemical sensors with extreme sensitivity using recently discovered physical processes in novel holey optical fibres. These sensors will be able to detect biological molecules, toxins or dangerous chemicals in minute concentrations, in very small sample sizes. The sensors can be mass-produced cheaply with current fabrication facilities within Australia, enabling their widespread use for water quality monitoring, environmental monitoring, threat detection, and rapid and reliable diagnosis in medicine.Read moreRead less
A Wearable Motion Analysis System: Novel Clinical and Research Applications. Because the biomechanical analysis of human motion is confined to the laboratory, it often has restricted applicability. This is a recognized limitation, because laboratory studies cannot capture the true picture of how individuals move under conditions encountered during daily living. Consequently there are many situations where a more complete and realistic knowledge of biomechanics would be significant advantage such ....A Wearable Motion Analysis System: Novel Clinical and Research Applications. Because the biomechanical analysis of human motion is confined to the laboratory, it often has restricted applicability. This is a recognized limitation, because laboratory studies cannot capture the true picture of how individuals move under conditions encountered during daily living. Consequently there are many situations where a more complete and realistic knowledge of biomechanics would be significant advantage such as in the diagnosis, treatment and rehabilitation of movement disorders and injuries. The research project described in this proposal would for the first time, obtain comprehensive biomechanical data outside the laboratory using a fully integrated wearable motion analysis system.Read moreRead less
Terahertz Metamaterials for Molecular Sensing. Metamaterials are fascinating new man-made structures that can manipulate beams of light in surprising ways; eg. metamaterials are being studied as 'cloaking devices' to render objects invisible. Our proposal aims for fundamental studies and improvement of metamaterials operating in the terahertz (T-ray) frequency regime. The outcome will be the exploitation of new metamaterial devices for high performance molecular sensors and electromagnetic filte ....Terahertz Metamaterials for Molecular Sensing. Metamaterials are fascinating new man-made structures that can manipulate beams of light in surprising ways; eg. metamaterials are being studied as 'cloaking devices' to render objects invisible. Our proposal aims for fundamental studies and improvement of metamaterials operating in the terahertz (T-ray) frequency regime. The outcome will be the exploitation of new metamaterial devices for high performance molecular sensors and electromagnetic filters operating at terahertz frequencies. Socioeconomic benefits to Australia include: (i) increased knowledge-base in metamaterials operating in the terahertz range; (ii) the underpinning of applications in biophotonics and communications; and (iii) commercialisation of novel terahertz devices.Read moreRead less
Comparison of Techniques for the Removal of Ocular Artefact from the Electroencephalogram: A Validation Study. Although employed extensively for both research and clinical purposes, the utility of the electroencephalograph (EEG) is hampered by the contaminating effects of eye movements on these 'brain waves'. If it can be validated, the recent Australian development of a solution to this problem will mean that the EEG can be measured more quickly and accurately. This purpose of this research is ....Comparison of Techniques for the Removal of Ocular Artefact from the Electroencephalogram: A Validation Study. Although employed extensively for both research and clinical purposes, the utility of the electroencephalograph (EEG) is hampered by the contaminating effects of eye movements on these 'brain waves'. If it can be validated, the recent Australian development of a solution to this problem will mean that the EEG can be measured more quickly and accurately. This purpose of this research is to perform this validation, and its success would mean both more efficient EEG recording for the country, as well as an enhanced scientific reputation.Read moreRead less
Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to ....Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to use innovative technology with expected high economic potential, and benefit small biotech companies by facilitating pre-clinical and clinical development of new pharmaceuticals. The new motion tracking and image reconstruction technologies developed will strengthen Australia's leading position in engineering and biomedical systems development.Read moreRead less
Frequency stabilisation in the Extremely High Frequency band. All precision communication and measurement systems (i.e. radar and navigation) rely on high quality oscillator technology. Any improvement in oscillator performance has a direct impact on the performance of the system and hence is of potential economic benefit. This project will realise the most stable frequencies ever produced in the underused Extremely High Frequency band, which is also important for space communications and naviga ....Frequency stabilisation in the Extremely High Frequency band. All precision communication and measurement systems (i.e. radar and navigation) rely on high quality oscillator technology. Any improvement in oscillator performance has a direct impact on the performance of the system and hence is of potential economic benefit. This project will realise the most stable frequencies ever produced in the underused Extremely High Frequency band, which is also important for space communications and navigation technology. System enhancement will include, better angular resolution, higher bandwidths, faster transmission rates and narrower beam widths without the susceptibility of absorption apparent from the optical domain.Read moreRead less
A Laser Guide Star using a High Power, Synchronously Pumped Optical Parametric Oscillators. We will develop a novel high power source of 589nm coherent (laser) light to be used to create a laser guide star by exciting sodium atoms in the earth's upper atmosphere (the mesosphere). This is needed to determine the distortion caused by the atmosphere on an optical beam propagating through it and generate the information needed to correct those distortions using an adaptive optics telescope. This pr ....A Laser Guide Star using a High Power, Synchronously Pumped Optical Parametric Oscillators. We will develop a novel high power source of 589nm coherent (laser) light to be used to create a laser guide star by exciting sodium atoms in the earth's upper atmosphere (the mesosphere). This is needed to determine the distortion caused by the atmosphere on an optical beam propagating through it and generate the information needed to correct those distortions using an adaptive optics telescope. This project focuses on the development of a novel high power 589nm source based on a synchronously pumped optical parametric oscillator.Read moreRead less
Optimisation of Signal-to-Noise Ratio in Electrical and Electromagnetic Investigations. Electrical and electromagnetic geophysical methods have been used extensively for mineral exploration, and are developing a role in salinity mapping and contaminant identification. To enhance the utility of such methods for very shallow targets (in the case of salinity) and deep targets (minerals beneath regolith)improved signal processing methods are required. The project involves the development of time-ser ....Optimisation of Signal-to-Noise Ratio in Electrical and Electromagnetic Investigations. Electrical and electromagnetic geophysical methods have been used extensively for mineral exploration, and are developing a role in salinity mapping and contaminant identification. To enhance the utility of such methods for very shallow targets (in the case of salinity) and deep targets (minerals beneath regolith)improved signal processing methods are required. The project involves the development of time-series processing techniques using robust-statistical methods and remote-referencing to improve signal-to-noise data quality. Instrumentation hardware and software developments are required for in-field data acquisition and interpretation, applied to direct current (DC) resistivity, induced polarisation (IP) and time-domain EM (TEM).Read moreRead less