Advanced technology for production of foreign proteins in plant cell and organ cultures. The aim of this project is to develop new technology for in vitro production of pharmaceutical proteins using plant tissue culture. Animal proteins such as antibodies are currently being produced using recombinant plant systems in bioreactors; however, transient gene expression using genetically-modified viruses has a range of potential benefits for substantially increasing foreign protein titres. Because vi ....Advanced technology for production of foreign proteins in plant cell and organ cultures. The aim of this project is to develop new technology for in vitro production of pharmaceutical proteins using plant tissue culture. Animal proteins such as antibodies are currently being produced using recombinant plant systems in bioreactors; however, transient gene expression using genetically-modified viruses has a range of potential benefits for substantially increasing foreign protein titres. Because viruses rapidly infect plant tissues and can be amplified to extremely high levels, this new method for in vitro foreign protein synthesis has considerable promise. This project will extend the existing science of plant tissue culture into new areas with commercial potential.Read moreRead less
Benign fabrication of microfluidic hydrogel for improved artificial vasculature in bone implants. We will create a benign technology for synthesising microfluidic hydrogels to generate artificial vascultures in bone implants. It is a critical step to enable the use of tissue-engineered vital organs, such as bone, heart and kidney in patients with end-stage organ failure. Thicker scaffolds will be possible, as the vasculature will provide nutrients and oxygen for cells to grow into 3D scaffolds. ....Benign fabrication of microfluidic hydrogel for improved artificial vasculature in bone implants. We will create a benign technology for synthesising microfluidic hydrogels to generate artificial vascultures in bone implants. It is a critical step to enable the use of tissue-engineered vital organs, such as bone, heart and kidney in patients with end-stage organ failure. Thicker scaffolds will be possible, as the vasculature will provide nutrients and oxygen for cells to grow into 3D scaffolds. It will promote capacity of Australia for manufacturing global biomaterial products for tissue engineering. We will also develop in-situ imaging analytical protocols for the rapid analysis of broad arrays of functional molecules, with significant bearing on BioMEMS design to develop methods for diagnosis of fatal diseases.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775513
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Advanced Process Tomography Research Facility for Multiphase System Studies. The establishment of an advanced process tomography facility at UNSW has several important national benefits, including; increased capacity of the collaborating institutions to train highly qualified personnel to meet new and growing demands in the processing industries; the transfer of research-based cheap and efficient technologies to our industries to enhance their position in a competitive global market; the improve ....Advanced Process Tomography Research Facility for Multiphase System Studies. The establishment of an advanced process tomography facility at UNSW has several important national benefits, including; increased capacity of the collaborating institutions to train highly qualified personnel to meet new and growing demands in the processing industries; the transfer of research-based cheap and efficient technologies to our industries to enhance their position in a competitive global market; the improvement in our culture and living standards through superior and inexpensive food, biomedical, water, environmental, materials and military products; and the strengthening of Australian position, through international linkage projects, as a world leader in the development of novel processing technologies.Read moreRead less
Engineering of cartilage-based biomaterials under dynamic culture conditions. This work contributes to the development of advanced technologies in the area of biomaterials. The cartilage biomaterials generated in this work will lead to new medical applications in tissue reconstruction and replacement, which is of direct benefit to society by improving the methods used to treat joint disease and injury. As there is a significant commercial market for tissue-engineered cartilage products, this res ....Engineering of cartilage-based biomaterials under dynamic culture conditions. This work contributes to the development of advanced technologies in the area of biomaterials. The cartilage biomaterials generated in this work will lead to new medical applications in tissue reconstruction and replacement, which is of direct benefit to society by improving the methods used to treat joint disease and injury. As there is a significant commercial market for tissue-engineered cartilage products, this research also has implications for enhancing the scope and profitability of the Australian biotechnology industry. The project will be a vehicle for research training in a broad range of interdisciplinary areas. Students involved in the work will be equipped with a versatile and valuable combination of skills.Read moreRead less
Application of bioreactors for culture of differentiated cells and solid-phase tissues. The aim of this project is to develop methods for producing three-dimensional human cartilage outside of the body. Tissue-engineered cartilage has a range of applications, including in toxicity testing, for production of therapeutics, and as surgical transplant devices. Bioreactors will be used to culture cartilage under controlled conditions for development of living tissues with properties as close as possi ....Application of bioreactors for culture of differentiated cells and solid-phase tissues. The aim of this project is to develop methods for producing three-dimensional human cartilage outside of the body. Tissue-engineered cartilage has a range of applications, including in toxicity testing, for production of therapeutics, and as surgical transplant devices. Bioreactors will be used to culture cartilage under controlled conditions for development of living tissues with properties as close as possible to those of native articular cartilage. Novel culture strategies will be used to enhance the availability of growth factors and provide adequate oxygen and nutrient exchange. These techniques have the potential to yield significant improvements in the quality of engineered cartilage.Read moreRead less