Enhancing biopharmaceuticals: A disruptive bioseparation resin technology. This project aims to develop an innovative and disruptive platform technology for designing and manufacturing tailor-made high-performance bioseparation resins to enhance biopharmaceuticals manufacturing. Bacterial cell factories will be developed to enable biotechnological production of innovative polyester bead-based bioseparation resins, which will revolutionise manufacturing of biopharmaceuticals. Expected outcomes o ....Enhancing biopharmaceuticals: A disruptive bioseparation resin technology. This project aims to develop an innovative and disruptive platform technology for designing and manufacturing tailor-made high-performance bioseparation resins to enhance biopharmaceuticals manufacturing. Bacterial cell factories will be developed to enable biotechnological production of innovative polyester bead-based bioseparation resins, which will revolutionise manufacturing of biopharmaceuticals. Expected outcomes of this project are cost-effective and strongly enhanced approaches for biopharmaceuticals recovery, thereby providing significant benefits to accelerate research and development in early stage discovery and manufacture of biologics, therapeutic proteins and vaccines.Read moreRead less
Accelerating pulse breeding using machine learning. Advances in genomics and high throughput phenotyping are generating vast quantities of data that can be applied for crop improvement, however the lack of computational analysis tools and approaches limits the full exploitation of this data. Pulse legumes are currently under utilised in Australian agriculture due to poor adaptation, however they offer significant benefits both for soil improvement and the production of high protein crops. This p ....Accelerating pulse breeding using machine learning. Advances in genomics and high throughput phenotyping are generating vast quantities of data that can be applied for crop improvement, however the lack of computational analysis tools and approaches limits the full exploitation of this data. Pulse legumes are currently under utilised in Australian agriculture due to poor adaptation, however they offer significant benefits both for soil improvement and the production of high protein crops. This project will develop machine learning (ML) tools for the analysis of pulse legume crop traits and their association with genomic variation to accelerate the breeding of high performance pulse legumes for Australian growers.Read moreRead less
Immobilized biocatalysts on selected filter media to control odour emissions from wastewater treatment and composting facilities. Odour is one of the common problems faced by wastewater and solid waste industries as a result of public complaints about poor local air quality. Although odour removal technologies exist, they encounter a number of problems. The lack of harsh chemicals required for the proposed technology means there is no wastewater stream to treat. This will have an impact on the r ....Immobilized biocatalysts on selected filter media to control odour emissions from wastewater treatment and composting facilities. Odour is one of the common problems faced by wastewater and solid waste industries as a result of public complaints about poor local air quality. Although odour removal technologies exist, they encounter a number of problems. The lack of harsh chemicals required for the proposed technology means there is no wastewater stream to treat. This will have an impact on the reduction of chemicals disposed to the environment, preventing unnecessary contamination of land and water resources. The lower space requirement of the technology will free up land, formerly required for large biofilters, for other uses including civic amenities.Read moreRead less
Superior Australian psyllium for functional foods. This project aims to establish a breeding program for Plantago ovata in Australia to provide a reliable supply of high quality, superior psyllium as a key ingredient in the gluten-free food industry, providing benefits to the industrial partner, growers in Australia and consumers. Target traits include better harvest index, reduced seed shattering and identification of lines carrying psyllium with novel properties or whole seeds that can be grou ....Superior Australian psyllium for functional foods. This project aims to establish a breeding program for Plantago ovata in Australia to provide a reliable supply of high quality, superior psyllium as a key ingredient in the gluten-free food industry, providing benefits to the industrial partner, growers in Australia and consumers. Target traits include better harvest index, reduced seed shattering and identification of lines carrying psyllium with novel properties or whole seeds that can be ground and used as flour that imparts less intense colour changes or effects on loaf structure, and which may be highly suitable for other baked gluten-free products. The fundamental knowledge gained from the genetic and biochemical anlayses of these lines will also broadly benefit seed biology research.Read moreRead less
Why are many fungicide lead compounds active against pathogens in axenic culture but inactive when applied to infected plants? It is much cheaper and easier to screen compounds for fungicidal activity in vivo (that is against the fungus grown in axenic culture) than to test in planta. However, it is commonly observed that compounds active in in vivo screens do not subsequently prove to be active in planta. The aim of this project is to investigate the physiological, biochemical and genetics basi ....Why are many fungicide lead compounds active against pathogens in axenic culture but inactive when applied to infected plants? It is much cheaper and easier to screen compounds for fungicidal activity in vivo (that is against the fungus grown in axenic culture) than to test in planta. However, it is commonly observed that compounds active in in vivo screens do not subsequently prove to be active in planta. The aim of this project is to investigate the physiological, biochemical and genetics basis of this discrepancy and to attempt to provide tools that circumvent the problem. It is expected the project will generate novel information on the environment in the plant experienced by the fungus.Read moreRead less
Fabrication of robust nanoscale optical biosensors using the novel spinning disc reactor technology. Spinning Disc Reactor (SDR) technology is new to Australia and will have wide ranging applications in nano-technology, and is destined to attract significant industrial interest beyond the proposed application in nano-scale biosensors. SDR is based on continuous flow and is more benign (less chemical waste) than traditional batch technology with a smaller footprint and significantly reduced capit ....Fabrication of robust nanoscale optical biosensors using the novel spinning disc reactor technology. Spinning Disc Reactor (SDR) technology is new to Australia and will have wide ranging applications in nano-technology, and is destined to attract significant industrial interest beyond the proposed application in nano-scale biosensors. SDR is based on continuous flow and is more benign (less chemical waste) than traditional batch technology with a smaller footprint and significantly reduced capital outlay. The emergence of SDR technology will revolutionize the practice of nano-engineering leading to miniaturization of devices, advances in information technologies and intelligent systems, and the revolution in medical science. The exciting research will enhance public opinion towards science.Read moreRead less
Development of class-leading bioluminescence resonance energy transfer technologies for real-time monitoring of molecular interactions. The purpose of this project is to develop improved technologies for identifying and developing pharmaceuticals with fewer side effects. The expected outcome is the development of technologies that provide a level of sensitivity and data quality that enables adoption by the biotechnology and pharmaceutical industries.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561042
Funder
Australian Research Council
Funding Amount
$852,705.00
Summary
Establishing a high-throughput Protein Production Unit. We seek to establish a world class high-throughput (H-T) protein production unit, the first of its kind in Australia. Throughout the unit robotic technology will be used to build and test protein expression systems as well as drive large scale protein production. The product of the unit will be high quality, pure protein, effective expression systems and world class research. The unit will act as a centre for research into H-T protein ex ....Establishing a high-throughput Protein Production Unit. We seek to establish a world class high-throughput (H-T) protein production unit, the first of its kind in Australia. Throughout the unit robotic technology will be used to build and test protein expression systems as well as drive large scale protein production. The product of the unit will be high quality, pure protein, effective expression systems and world class research. The unit will act as a centre for research into H-T protein expression technology, will underpin the finest biological research, provide the basis for large "structural genomic" type approaches to biological problems and provide a wealth of projects for the Australian synchrotron.Read moreRead less
Expanding the gene pool of canola (Brassica napus) by introgressing valuable genes from related species. Canola is a high value export crop from Australia, and an important rotational crop which improves sustainability of agriculture through a disease and weed break for cereal crops. While breeders have improved quality, disease resistance and adaptation of canola to Australian conditions over the past 30 years, this has reduced genetic variation to dangerously low levels. Wide crossing with d ....Expanding the gene pool of canola (Brassica napus) by introgressing valuable genes from related species. Canola is a high value export crop from Australia, and an important rotational crop which improves sustainability of agriculture through a disease and weed break for cereal crops. While breeders have improved quality, disease resistance and adaptation of canola to Australian conditions over the past 30 years, this has reduced genetic variation to dangerously low levels. Wide crossing with drought tolerant Brassica carinata (Ethiopean mustard) will help to alleviate this problem. New uses of biotechnology, combined with molecular genetics, will help to overcome species barriers to introduce useful new genes into canola for Australian canola breeders.Read moreRead less
Special Research Initiatives - Grant ID: SR0354766
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Molecular farming: seizing the opportunity to establish a new technology based, value adding industry in and for Australia. Molecular farming involves the production of novel products in plants and brings together the technology to genetically modify plants to produce these products with efficient production of plant biomass. The range of potential products is very broad and includes therapeutic and industrial proteins, bioplastics, fibres, food additives, glues and dyes. The molecular farming i ....Molecular farming: seizing the opportunity to establish a new technology based, value adding industry in and for Australia. Molecular farming involves the production of novel products in plants and brings together the technology to genetically modify plants to produce these products with efficient production of plant biomass. The range of potential products is very broad and includes therapeutic and industrial proteins, bioplastics, fibres, food additives, glues and dyes. The molecular farming industry is already established in North America with products on the market. Australia has an outstanding opportunity to participate in this new industry as a producer if we can aggregate the critical scientific mass and work together with the current fledgling industry and State and Federal regulators.Read moreRead less