Enhancing biopharmaceuticals: A disruptive bioseparation resin technology. This project aims to develop an innovative and disruptive platform technology for designing and manufacturing tailor-made high-performance bioseparation resins to enhance biopharmaceuticals manufacturing. Bacterial cell factories will be developed to enable biotechnological production of innovative polyester bead-based bioseparation resins, which will revolutionise manufacturing of biopharmaceuticals. Expected outcomes o ....Enhancing biopharmaceuticals: A disruptive bioseparation resin technology. This project aims to develop an innovative and disruptive platform technology for designing and manufacturing tailor-made high-performance bioseparation resins to enhance biopharmaceuticals manufacturing. Bacterial cell factories will be developed to enable biotechnological production of innovative polyester bead-based bioseparation resins, which will revolutionise manufacturing of biopharmaceuticals. Expected outcomes of this project are cost-effective and strongly enhanced approaches for biopharmaceuticals recovery, thereby providing significant benefits to accelerate research and development in early stage discovery and manufacture of biologics, therapeutic proteins and vaccines.Read moreRead less
A “Goldilocks” live attenuated poultry vaccine for Infectious Coryza. This project aims to develop a safe and effective vaccine for Infectious Coryza using a live-attenuated vaccine approach. Infectious coryza is an acute respiratory disease of chickens and is caused by the bacterial pathogen, Avibacterium paragallinarum. Infectious Coryza can be controlled by appropriate biosecurity practises and this has been successful in the Australian context to date. However, in the USA, Europe and other e ....A “Goldilocks” live attenuated poultry vaccine for Infectious Coryza. This project aims to develop a safe and effective vaccine for Infectious Coryza using a live-attenuated vaccine approach. Infectious coryza is an acute respiratory disease of chickens and is caused by the bacterial pathogen, Avibacterium paragallinarum. Infectious Coryza can be controlled by appropriate biosecurity practises and this has been successful in the Australian context to date. However, in the USA, Europe and other equatorial regions, infectious Coryza remains an unsolved problem. The expected outcome of this project is a cross-serovar protective vaccine to prevent infectious coryza for use in endemic countries and to act as a biosecurity measure to protect Australia's poultry industry against an incursion of this disease.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH190100021
Funder
Australian Research Council
Funding Amount
$4,999,540.00
Summary
ARC Research Hub to Combat Antimicrobial Resistance. The ARC ITRP Research Hub to Combat Antimicrobial Resistance takes on the global challenge of antimicrobial resistance (AMR) for Australia through a world-first partnership between industry, researchers, and end users. The AMR Hub fosters a pre-commercialisation environment to address both social and laboratory-based preclinical challenges to provide a highly integrated diagnostic, pharmaceutical and end user solution to the problem of AMR. A ....ARC Research Hub to Combat Antimicrobial Resistance. The ARC ITRP Research Hub to Combat Antimicrobial Resistance takes on the global challenge of antimicrobial resistance (AMR) for Australia through a world-first partnership between industry, researchers, and end users. The AMR Hub fosters a pre-commercialisation environment to address both social and laboratory-based preclinical challenges to provide a highly integrated diagnostic, pharmaceutical and end user solution to the problem of AMR. A goal of the Hub is to support the development of new molecular diagnostic technology, improve the processes for identifying potential antibiotic compounds and assess and advise on antimicrobial stewardship with a vision to transform social and health outcomes globally.Read moreRead less
Toxic metal removal from wastewater sludge. This project aims to efficiently remove toxic metals from wastewater sludge. Sludge management is a problem for water utilities, incurring substantial costs. Land application of wastewater sludge is a sustainable way of sludge management, but toxic metals hinder its long-term repeated application. The project’s chemical-free and energy-positive technology is based on the treatment of wastewater sludge using acidified nitrite. The outcomes will help wat ....Toxic metal removal from wastewater sludge. This project aims to efficiently remove toxic metals from wastewater sludge. Sludge management is a problem for water utilities, incurring substantial costs. Land application of wastewater sludge is a sustainable way of sludge management, but toxic metals hinder its long-term repeated application. The project’s chemical-free and energy-positive technology is based on the treatment of wastewater sludge using acidified nitrite. The outcomes will help water utilities to sustainably manage sludge and could bring large economic, environmental and social benefits to the water utilities.Read moreRead less
The Integrated Bio-economy Project and the Controlled Biosphere. This project aims to develop advanced controlled environment production systems (Controlled Biosphere) that exceed the industry standard for profitability, sustainability and climatic resilience. It will generate new knowledge and innovations in technology integration through a highly multi-disciplinary approach. The project outcomes will yield Techno-Economic and Life-Cycle Analyses, designs of the Controlled Biosphere and support ....The Integrated Bio-economy Project and the Controlled Biosphere. This project aims to develop advanced controlled environment production systems (Controlled Biosphere) that exceed the industry standard for profitability, sustainability and climatic resilience. It will generate new knowledge and innovations in technology integration through a highly multi-disciplinary approach. The project outcomes will yield Techno-Economic and Life-Cycle Analyses, designs of the Controlled Biosphere and supporting policy frameworks. The benefits of this project address worsening resource constraints (e.g. available fresh water, arable land, nutrients); By 2050 we will require 70% more food, and 80% greenhouse gas emissions reductions, to maintain economic, social, political and climate security.Read moreRead less
Novel Propagation and Conservation Technologies for Australian Macadamia. Australia’s $850M macadamia industry is a booming contributor to regional growth with a strong domestic market niche. However the industry is threatened by a severe plant supply bottleneck. Also wild germplasm for breeding is threatened with extinction. This project aims to innovate world-first tissue culture technologies for macadamia propagation and secure cryo-storage of germplasm, aided by cutting edge genomics. Expect ....Novel Propagation and Conservation Technologies for Australian Macadamia. Australia’s $850M macadamia industry is a booming contributor to regional growth with a strong domestic market niche. However the industry is threatened by a severe plant supply bottleneck. Also wild germplasm for breeding is threatened with extinction. This project aims to innovate world-first tissue culture technologies for macadamia propagation and secure cryo-storage of germplasm, aided by cutting edge genomics. Expected outcomes of these new, cross-disciplinary techniques are on-demand supply of superior trees to growers and the protection of invaluable germplasm. This should provide significant benefits for industry growth, food security and conservation de-risked from global change.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC160100027
Funder
Australian Research Council
Funding Amount
$4,340,802.00
Summary
ARC Training Centre for Biopharmaceutical Innovation. ARC Training Centre for Biopharmaceutical Innovation. This centre aims to transform Australia’s growing biopharmaceutical industry, an advanced manufacturing capability, by training specialist biotechnologists and bioengineers. It expects the research and development outputs will create new biopharmaceuticals and antibody-based reagents, enhanced production methods, improved manufacturing capabilities and a cohort of specialist scientists. Ne ....ARC Training Centre for Biopharmaceutical Innovation. ARC Training Centre for Biopharmaceutical Innovation. This centre aims to transform Australia’s growing biopharmaceutical industry, an advanced manufacturing capability, by training specialist biotechnologists and bioengineers. It expects the research and development outputs will create new biopharmaceuticals and antibody-based reagents, enhanced production methods, improved manufacturing capabilities and a cohort of specialist scientists. New biopharmaceuticals are expected to benefit the Australian economy and provide new therapeutic options for better health outcomes. Industry-driven research projects will also provide industry-ready graduates who can drive future growth in the sector.Read moreRead less
Efficient CO and CO2 conversion to biopolymers using phototrophic bacteria. This project aims to deliver efficient processes for the large-scale production of biopolymers from low cost inputs, using phototrophic bacteria. Feedstocks include syngas from solid wastes and carbon-dioxide-hydrogen mixes from fossil and renewable sources. The choice of phototrophic bacteria avoids the energy losses associated with existing technologies, since photons are used instead of chemical energy for metabolic n ....Efficient CO and CO2 conversion to biopolymers using phototrophic bacteria. This project aims to deliver efficient processes for the large-scale production of biopolymers from low cost inputs, using phototrophic bacteria. Feedstocks include syngas from solid wastes and carbon-dioxide-hydrogen mixes from fossil and renewable sources. The choice of phototrophic bacteria avoids the energy losses associated with existing technologies, since photons are used instead of chemical energy for metabolic needs. This project enables the production and optimisation of biopolymers through collaborations between engineers, polymer scientists and molecular biologists. The project will deliver technologies to produce tough, flexible and affordable biopolymers, converting wastes and greenhouse gases to a valuable product.Read moreRead less
Simultaneous dissolved methane and nitrogen removal. Direct anaerobic treatment of wastewater converts majority of organic matters in wastewater to methane, an energy source. However, up to 50% of the methane produced stays dissolved in wastewater. Its subsequent stripping to atmosphere in aerobic treatment not only causes significant loss of energy but also emission of a potent greenhouse gas. This project aims to develop a technology that not only avoids methane stripping but also enables its ....Simultaneous dissolved methane and nitrogen removal. Direct anaerobic treatment of wastewater converts majority of organic matters in wastewater to methane, an energy source. However, up to 50% of the methane produced stays dissolved in wastewater. Its subsequent stripping to atmosphere in aerobic treatment not only causes significant loss of energy but also emission of a potent greenhouse gas. This project aims to develop a technology that not only avoids methane stripping but also enables its beneficial use to enhance nitrogen removal, which is otherwise typically unsatisfactory due to the lack of organic carbon to support denitrification. The project will provide strong support to the Australian water industry in their endeavour to achieve energy- and carbon-neutral wastewater services.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH190100014
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Sustainable Onshore Lobster Aquaculture. The project aims to build knowledge to establish the world’s first sustainable onshore lobster aquaculture industry focused on commercial, sustainable and socially responsible lobster production from hatchery to market. The project will investigate novel systems engineering, specialised feed manufacture, determination and modification of seedstock quality, new frontiers in seedstock transport, all within an informed environmental and ....ARC Research Hub for Sustainable Onshore Lobster Aquaculture. The project aims to build knowledge to establish the world’s first sustainable onshore lobster aquaculture industry focused on commercial, sustainable and socially responsible lobster production from hatchery to market. The project will investigate novel systems engineering, specialised feed manufacture, determination and modification of seedstock quality, new frontiers in seedstock transport, all within an informed environmental and marketing framework. The project will provide alternate solutions for lobster culture in bio-secure and cost effective onshore systems. The outcomes are targeted at positioning Australia at the forefront of onshore lobster aquaculture, with opportunity for technology transfer to other aquaculture sectors.Read moreRead less