Dissecting The Great Ophthalmic Masquerade: The Global Giant Cell Arteritis Genomics Consortium.
Funder
National Health and Medical Research Council
Funding Amount
$583,269.00
Summary
Giant cell arteritis (GCA) is the most common form of vasculitis in people over 50 years of age. If untreated it can cause catastrophic complications including blindness, though this can be prevented if treated early. Although there is clear evidence for a role of genetic factors in GCA, these have been little studied. We have established an Australian-led International consortium, with clinical, basic science and statistical expertise to thoroughly investigate this devastating disease.
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Translating Genetic Determinants Of Glaucoma Into Better Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$9,466,000.00
Summary
Glaucoma is the leading cause of irreversible blindness worldwide. By 2020, it will affect 80 million people, and in Australia over the next decade, the overall cost of glaucoma will reach $4.3 billion per annum. This Program will use genetic advances to personalise treatment. Blindness will be prevented in individuals at highest risk, new ways to treat patients will be developed, and better outcomes for patients will result from less treatment and monitoring of low risk cases.
A Genome-wide Association Study In 2000 Glaucoma Cases With Matched Controls Using Equimoloar DNA Pools
Funder
National Health and Medical Research Council
Funding Amount
$610,267.00
Summary
Glaucoma is a common cause of loss of vision worldwide but we are unable to predict which people are at high risk of blindness. We aim to discover the genetic risk factors for glaucoma. We will use cutting edge genetic technology to assess the whole genome in thousands of patients with glaucoma. We hope to identify important new glaucoma genes, which could lead to the development of diagnostic tests and treatments which will provide the most cost-efficient ways to prevent glaucoma blindness.
Optimising Heart Disease Prevention And Management
Funder
National Health and Medical Research Council
Funding Amount
$4,647,175.00
Summary
As we become older and risk factors such as obesity become more common, our biggest contributor to death and disability, cardiovascular disease (including heart disease), will continue to exert an enormous burden on our health care system and society. We will extend our ground-breaking research on multidisciplinary teams to create new and innovative health care programs to optimise the prevention and management of new heart disease and chronic forms of heart disease.
Discovery Early Career Researcher Award - Grant ID: DE230101466
Funder
Australian Research Council
Funding Amount
$442,723.00
Summary
Violent offenders in the night-time economy: Building the evidence. Alcohol-related violence in entertainment precincts is a significant community safety problem. This project aims to improve knowledge on individuals that are violent in entertainment precincts. It is expected to be the first study globally to use linked data to develop multi-system informed offending trajectories of violent offenders in these settings, examine the impact of patrons bans on offending trajectories, and apply situa ....Violent offenders in the night-time economy: Building the evidence. Alcohol-related violence in entertainment precincts is a significant community safety problem. This project aims to improve knowledge on individuals that are violent in entertainment precincts. It is expected to be the first study globally to use linked data to develop multi-system informed offending trajectories of violent offenders in these settings, examine the impact of patrons bans on offending trajectories, and apply situational action theory to alcohol-related violence. Results are expected to inform a critical knowledge gap and assist in the development of targeted violence preventive responses which reduce harm and make communities safer.Read moreRead less
The Management To Optimise Diabetes And MEtabolic Syndrome Risk Reduction Via Nurse-led Intervention (MODERN) Study
Funder
National Health and Medical Research Council
Funding Amount
$1,445,861.00
Summary
There is increasing recognition of society’s responsibility to provide effective and sustainable health care to the entire population and not just selected parts. This practical study will test the impact of a nurse-led, multidisciplinary prevention program to reduce the risk of future cardiovascular events in middle-aged individuals at a high risk of developing cardiovascular disease (CVD) living in regional Australia.
Discovery Early Career Researcher Award - Grant ID: DE200100359
Funder
Australian Research Council
Funding Amount
$420,960.00
Summary
Preventing crime in public spaces: everyday guardianship & territoriality . Safe public spaces are the cornerstone of liveable cities. Everyday users of public spaces are vital crime prevention guardians because they are frequently present in the absence of formal regulators like police. This project will investigate factors that enhance active guardianship and facilitate crime prevention in public spaces. It aims to generate new knowledge on the extent to which everyday users of public spaces d ....Preventing crime in public spaces: everyday guardianship & territoriality . Safe public spaces are the cornerstone of liveable cities. Everyday users of public spaces are vital crime prevention guardians because they are frequently present in the absence of formal regulators like police. This project will investigate factors that enhance active guardianship and facilitate crime prevention in public spaces. It aims to generate new knowledge on the extent to which everyday users of public spaces develop a sense of territorial control leading to conscious monitoring of public spaces and intervention in social problems. The project aims to inform crime prevention strategies that facilitate active guardianship leading to less crime, reduced fear of crime and enhanced opportunities for pro-social use of public spaces. Read moreRead less
Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to de ....Targeting early contact with the criminal justice system in young people. This project aims to identify who and why young people first come in contact with the criminal justice system and what determines the early course of contact. The project will focus on first police contact, as a victim, witness or offender, as a means of identifying young people at-risk of adverse life outcomes. It intends to build on the NSW Child Development Study, a large population-based intergenerational cohort, to develop services and interventions aimed at preventing young people from becoming enmeshed in the criminal justice system.Read moreRead less
A Multi-centre RCT To Prevent Secondary Falls In Older People Presenting To The Emergency Department With A Fall
Funder
National Health and Medical Research Council
Funding Amount
$1,534,471.00
Summary
Falls are a leading cause for presentation to Emergency Departments (EDs) by older patients. More than 50% who present to ED with a fall injury have fallen in the previous year. RESPOND is an innovative post-ED discharge program designed to reduce secondary falls in older people. RESPOND extends current falls prevention research and practice by incorporating patient-centred education with behaviour change strategies proven to be effective in the secondary prevention of cardiovascular events.