Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Defining how molecular switches program cell identity during development. Aims: This project aims to investigate how molecular switches known as transcription factors, work together to turn genes on or off to program cell identity during development.
Significance: This project expects to generate new knowledge in the area of genetics and developmental biology using collaborative, cutting edge technologies.
Outcomes: Expected outcomes of this project include the identification of new genes impor ....Defining how molecular switches program cell identity during development. Aims: This project aims to investigate how molecular switches known as transcription factors, work together to turn genes on or off to program cell identity during development.
Significance: This project expects to generate new knowledge in the area of genetics and developmental biology using collaborative, cutting edge technologies.
Outcomes: Expected outcomes of this project include the identification of new genes important for programming the identity of cells that comprise our blood vessels, lymphatic vessels and circulating blood cells.
Benefits: Data generated will underpin the development of approaches to program/reprogram stem cells to produce mature cells for transplantation or tissue engineering purposes ex vivo.Read moreRead less
Nuclear magnetic resonance (NMR) of molecules and cells in media with 'tunable' anisotropy: high rank-spins, z-spectra, (pro)chiral discrimination, peptide L-to-D isomerase. This project will build on this team's invention of a stretched-gel method that reports on molecular composition and the geometrical arrangement of atoms into mirror image arrays, using nuclear magnetic resonance spectroscopy. The project will use the methodology to determine roles of a platypus venom enzyme that carries out ....Nuclear magnetic resonance (NMR) of molecules and cells in media with 'tunable' anisotropy: high rank-spins, z-spectra, (pro)chiral discrimination, peptide L-to-D isomerase. This project will build on this team's invention of a stretched-gel method that reports on molecular composition and the geometrical arrangement of atoms into mirror image arrays, using nuclear magnetic resonance spectroscopy. The project will use the methodology to determine roles of a platypus venom enzyme that carries out stereoscopic interconversions, even in humans.Read moreRead less
Ultra-fast serialised all optical image processing: addressing the electronic bottleneck in the world's fastest camera. Serial time encoded amplified microscopy can capture over a million frames per second. At this rate, a megapixel image would fill a terabyte hard disk in a second. We will use photonics to condense and manipulated the video stream so that only the important features are 'seen', making it practical to process and store on a computer.