Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Whole Body Vibration For Osteoporosis: Shaking Up Our Treatment Options
Funder
National Health and Medical Research Council
Funding Amount
$961,017.00
Summary
Our aim is to examine the ability of vibration alone and in combination with osteoporosis drugs to reduce hip fracture in postmenopausal women. In Australia, 1 in 2 women >60yrs, will sustain an osteoporotic fracture. Only drugs notably decrease fracture; however none are entirely effective and some patients don’t respond. Whole body vibration has emerged as a potentially effective therapy. A combination of vibration and drugs may enhance the effects of both and revolutionise treatment.
Investigating the effectiveness of teacher education for early career teachers in diverse settings: a longitudinal study. This project investigates the effectiveness of teacher education programs in Victoria and Queensland in preparing teachers for the variety of school settings in which they begin their careers. The findings will inform state and national policy, as well as the work of professional regulation authorities and teacher education providers.
Naming the world: early years literacy and sustainability learning. The project seeks to produce knowledge about new forms of literacy emerging in sustainability education. For children born in the 21st century, the enmeshing of natural and human forces in the survival of the planet requires conceptual and practical innovation. Early childhood education can be a fundamental driver in this process. This project aims to integrate literacy and sustainability to produce powerful new learning for you ....Naming the world: early years literacy and sustainability learning. The project seeks to produce knowledge about new forms of literacy emerging in sustainability education. For children born in the 21st century, the enmeshing of natural and human forces in the survival of the planet requires conceptual and practical innovation. Early childhood education can be a fundamental driver in this process. This project aims to integrate literacy and sustainability to produce powerful new learning for young children. It plans to theorise new forms of literacy emerging in sustainability education, articulate innovative pedagogies, and inform national and international policy and practice to address 21st century learning imperatives.Read moreRead less
Pursuing equity in high poverty rural schools: improving learning through rich accountabilities. Poor performance of students in schools located in high poverty communities is a pressing educational problem for Australia, with educational disadvantage in poor rural communities in particular demanding amelioration. The evidence suggests the equity and quality of schooling outcomes are centrally important to the nation's economic future, the strength of Australian democracy, social inclusion and a ....Pursuing equity in high poverty rural schools: improving learning through rich accountabilities. Poor performance of students in schools located in high poverty communities is a pressing educational problem for Australia, with educational disadvantage in poor rural communities in particular demanding amelioration. The evidence suggests the equity and quality of schooling outcomes are centrally important to the nation's economic future, the strength of Australian democracy, social inclusion and a unified nation. In strengthening policy and practice knowledge about educative usage of performance data and the development of rich forms of accountability, the research will advance the academic literature and provide an evidence base for success of the national partnership on low socio-economic status schools.Read moreRead less
Education meets play: a sociological study of how the new compulsory national learning framework for children zero to five years influences educators' practice. New theorising about play and education in early childhood settings has challenged traditional notions of play. This project investigates how educators respond to the requirement for play-based learning by identifying characteristics of successful educators and professional leaders, and strategies and practices that merge education and p ....Education meets play: a sociological study of how the new compulsory national learning framework for children zero to five years influences educators' practice. New theorising about play and education in early childhood settings has challenged traditional notions of play. This project investigates how educators respond to the requirement for play-based learning by identifying characteristics of successful educators and professional leaders, and strategies and practices that merge education and play.Read moreRead less
Understanding How Language And Reading Problems Develop: A Population-based Longitudinal Study From Infancy To Age 7
Funder
National Health and Medical Research Council
Funding Amount
$667,507.00
Summary
Early language and reading problems are common and therefore significant public health problems. They are disabling and have life-long implications for oral and written communication skills, social and emotional well-being, cognition, behaviour, academic achievement and employment. This study will address the following three problems: 1. To date no study has documented how language and reading problems develop from infancy (8 months) through to school age (7 years). 2. Little is known about risk ....Early language and reading problems are common and therefore significant public health problems. They are disabling and have life-long implications for oral and written communication skills, social and emotional well-being, cognition, behaviour, academic achievement and employment. This study will address the following three problems: 1. To date no study has documented how language and reading problems develop from infancy (8 months) through to school age (7 years). 2. Little is known about risk factors, identified early in infancy and childhood, that can be reliably used to predict language and reading problems later in childhood. 3. The relationships between language difficulties and reading problems are poorly understood. Therefore, we currently have no satisfactory methods for reliably detecting which children at much younger ages are at risk of later language disorders or reading problems. Without this information it is impossible to develop effective prevention and early intervention programs. These programs are critical if we are to: a) Prevent language and reading problems from occurring, thereby reducing the prevalence of the problem b) Intervene early in childhood, thereby reducing in the longer term the burden and cost associated with language and reading problems. The proposed study builds on an existing substantial investment by the NHMRC in the Early Language in Victoria Study (ELVS). It will provide a world-first description of the evolution of language difficulties and reading problems from infancy through to school age within a single population cohort.Read moreRead less
School retention and second chance schooling. This project is concerned with ensuring that students who experience systemic disadvantage are not excluded from the benefits of a formal education. It provides an account and critique of the growth of second chance schooling options catering to such students in both Australia and the UK.
Community variations in crime: A spatial and ecometric analysis. Collective Efficacy (CE) is a new theoretical construct (that has never been investigated in Australia). It is a task-specific process for mobilising social capital to tackle specific neighbourhood problems. Research in Chicago finds that communities with high levels of CE experience lower levels of violence regardless of poverty levels. We will conduct a spatial and ecometric analysis of CE and crime using a survey of 3000 residen ....Community variations in crime: A spatial and ecometric analysis. Collective Efficacy (CE) is a new theoretical construct (that has never been investigated in Australia). It is a task-specific process for mobilising social capital to tackle specific neighbourhood problems. Research in Chicago finds that communities with high levels of CE experience lower levels of violence regardless of poverty levels. We will conduct a spatial and ecometric analysis of CE and crime using a survey of 3000 residents in 50 Brisbane communities. We will compare similar data from Chicago and Stockholm to investigate the Australian contribution of CE to spatial crime patterns and its potential for future crime prevention programs.Read moreRead less
Peopling educational policy: realising the new Australian English and mathematics curricula. Implementation of Australian curricula in English and mathematics provides an opportunity for school systems to re-examine practice. This project will identify resources and teacher learning opportunities needed to facilitate implementation of these curricula and use findings to develop interventions identified as likely to optimise implementation.