GENETIC PREDICTION OF FRACTURE IN A RISK-STRATIFIED POPULATION
Funder
National Health and Medical Research Council
Funding Amount
$363,000.00
Summary
Osteoporosis is a condition characterised by excessive bone loss and impaired bone quality, which ultimately results in fracture with minimal trauma. Osteoporosis affects 27% of women and 11% of men aged 60 years or above in the community, and costs Australia around $7 billion each year. Individuals with low bone mineral density (BMD) have a significantly higher risk of fracture than those with normal BMD. In the long-term (14-year) Dubbo Osteoporosis Epidemiology Study, more than half of indivi ....Osteoporosis is a condition characterised by excessive bone loss and impaired bone quality, which ultimately results in fracture with minimal trauma. Osteoporosis affects 27% of women and 11% of men aged 60 years or above in the community, and costs Australia around $7 billion each year. Individuals with low bone mineral density (BMD) have a significantly higher risk of fracture than those with normal BMD. In the long-term (14-year) Dubbo Osteoporosis Epidemiology Study, more than half of individuals with osteoporosis (e.g., low BMD) did not sustain a fracture, while approximately 60% of fracture cases had BMD above the high risk levels. Thus, BMD alone is not a good discriminant of fracture versus non-fracture cases. It is widely known that the liability to fracture is determined in part by genes. Previous studies, including from our group, have suggested a number of candidate genes that are associated with fracture risk. The fundamental issue that this study is concerned is that how and whether genetic markers could be used to facilitate case finding. It is proposed that common variations of certain genes are associated with fracture risk independent of BMD. That is, they can identify individuals at relatively high and low fracture risk after stratification for BMD. Hence, some markers may identify those individuals likely (and unlikely) to fracture even with low (osteoporotic) BMD. Similarly, some, possibly the same, markers may identify individuals at high risk of fracture despite relatively good (ie non-osteoporotic) BMD. It is further proposed that no single gene will achieve this outcome, but rather a small set of such gene polymorphisms will provide clinically useful risk information. This effect is entirely analogous to the use of clinical risk indicators (eg, age, weight, sex, family history, etc) to assess the risk of future fracture.Read moreRead less
Myeloma Plasma Cell Dormancy - 'Eradicating The Sleeping Giant'
Funder
National Health and Medical Research Council
Funding Amount
$834,428.00
Summary
Multiple myeloma is a fatal cancer that develops in the skeleton. Current therapies are initially effective, but patients develop resistance and the disease returns. This makes the search for drugs to overcome resistance a priority. Myeloma cells can hide in bone in a dormant state where they are insensitive to chemotherapy. We have identified new drug targets in dormant cells. We are investigating whether these new targets can be used eradicate myeloma cells and cure the disease.
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The present research seeks to redress this situation by analysing computer ....An Analysis of the Cultural, Social and Symbolic Performance of Computer-Generated, Post-Euclidean, Architecture in Australia. Computer Aided Design software has recently provided architects with the ability to use post-Euclidean geometry for the creation of buildings. As the first of these buildings are only now being completed the social, cultural and symbolic performance of this new approach to design remains unknown.
The present research seeks to redress this situation by analysing computer-generated public buildings, completed in Australia after 1998. These buildings represent a substantial outlay of public funding and a significant social investment in Australian cities.
This research will result in a critical evaluation strategy for public and institutional bodies interested in procuring such buildings.Read moreRead less
Embodied energy modelling of individual commercial buildings. This research will develop a method for modelling the energy embodied in individual commercial building construction. Construction material manufacturing emissions are well known in most industries, but the total embodied energy of the construction supply chain is difficult to model for individual buildings. For efficient commercial buildings, the embodied energy can represent up to 40 years of operational energy. The results will be ....Embodied energy modelling of individual commercial buildings. This research will develop a method for modelling the energy embodied in individual commercial building construction. Construction material manufacturing emissions are well known in most industries, but the total embodied energy of the construction supply chain is difficult to model for individual buildings. For efficient commercial buildings, the embodied energy can represent up to 40 years of operational energy. The results will be used to develop cost effective strategies for optimising the total life cycle energy of individual commercial buildings. This will in part improve the environmental performance of the Australian construction industry.Read moreRead less