From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
Determination Of Irradiation Dose Efficacy For Use In Impaction Grafting At Revision Joint Replacement
Funder
National Health and Medical Research Council
Funding Amount
$411,517.00
Summary
Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence ....Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence of early complications of this procedure have included loss of fixation within the bone. Fracture of the bone around prostheses has also reported in some centres. These events require more surgery, putting the patient at higher risk greater complications and longer rehabilitations. Recent improvements in surgical technique and donor bone preparation have improved results. A current debate questions whether the dose of irradiation can be reduced from 25 kGy, while maintaining sterility of allografts. The risk of bacterial contamination in allografts is low, and irradiation reduces the mechanical strength of the graft, contributing to complications when irradiated bone is used. The benefits of decontaminating the bone may be outweighed by the higher risk for failure due to poor bone quality and resulting prosthesis instability. We will use ISO standards to test the validity of radiation dose for sterilising bone ex vivo. In the absence of controlled human studies, our aim is also to compare the results of impaction grafting with non-irradiated bone versus bone irradiated at current doses used by Australian bone banks, and lower doses indicated by ex vivo testing. We will use a large animal model of revision hip replacement, with precise measures of prosthesis stability. The results of this study will guide clinical decisions regarding the efficacy of current bone graft preparation procedures and the use of irradiated bone in human hip replacement surgery.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100229
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
A prototype Scanning Helium Atom Microscope (SHeM) for soft materials. The scanning helium atom microscope (SHeM) has been a tantalising prospect since the birth of quantum physics. The SHeM would have unparalleled resolution and would be completely non-damaging; potentially revolutionising the imaging of soft delicate materials. This project will develop the first SHeM instrument in Australia to study soft matter.
Learning how people read: Models, brains, big data and maths. Aims: This project aims to understand how people read. We will use novel mathematical methods, experimentation, brain imaging and computational modelling to adjudicate between model predictions.
Significance: This project expects to develop methods to understand and test important aspects of reading.
Expected outcomes: Expected outcomes are the development of novel methods for understanding complex models and the collection of data t ....Learning how people read: Models, brains, big data and maths. Aims: This project aims to understand how people read. We will use novel mathematical methods, experimentation, brain imaging and computational modelling to adjudicate between model predictions.
Significance: This project expects to develop methods to understand and test important aspects of reading.
Expected outcomes: Expected outcomes are the development of novel methods for understanding complex models and the collection of data that can extend and falsify current models of reading.
Benefits: These developments will significantly increase our understanding of how people read and what causes dyslexia. This work will also provide new ways to evaluate complex computational psychological models.Read moreRead less
How are beliefs altered by data? Robust Bayesian models for human inductive learning. This project applies state of the art mathematical models to study how people think and reason, and how we can make good guesses about the future. The goal is to understand how the human mind can operate so effectively in real environments, when even the most powerful computers struggle to handle the complexities of everyday learning problems.
Learning and choosing in a complex world. How do people make choices in a complex world? Making good choices requires expertise, but people must often forego rewards in order to acquire this knowledge. This is the essence of an "explore-exploit dilemma": to maximise rewards across a long time frame, people must take the time to explore and learn now. Empirically, this project aims to unify much of the existing psychological literature and extend it to cover richer, more complex problems. Theoret ....Learning and choosing in a complex world. How do people make choices in a complex world? Making good choices requires expertise, but people must often forego rewards in order to acquire this knowledge. This is the essence of an "explore-exploit dilemma": to maximise rewards across a long time frame, people must take the time to explore and learn now. Empirically, this project aims to unify much of the existing psychological literature and extend it to cover richer, more complex problems. Theoretically, the project aims to use tools from machine learning to compare human decision making to optimal planning models.Read moreRead less
The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the ....The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the project will answer a question critical to workplace safety - how much time off between shifts is needed to be alert and safe at work? The project will also produce tools to help industry design fatigue-friendly rosters, improving the safety, productivity and general well-being of shiftworkers in Australia and overseas.Read moreRead less
How The Lateral Habenula Integrates Behavioral And Autonomic Functions: The VTA Dopamine Connection
Funder
National Health and Medical Research Council
Funding Amount
$819,904.00
Summary
When adverse events occur, the lateral habenula, an old brain nucleus, helps calculate the wisest corrective action by contributing to the “brake” that controls the brain’s dopamine reward system. Our research will show how the lateral habenula links corrective changes in behavior with coordinated changes in temperature. Understanding this link will greatly contribute to understanding the brain mechanisms that regulate our physiology during stressful situations and as part of mental illness.