Unraveling Mechanisms Of Liver Transplant Tolerance
Funder
National Health and Medical Research Council
Funding Amount
$694,822.00
Summary
Liver transplants are unique amongst solid organs as they are spontaneously accepted across different individuals and induce acceptance of other organs from the same donor co-transplanted at the same time. Using a new mouse liver transplantation model, this proposal will elucidate how the liver tissue performs this function and identify new markers associated with tolerance in the blood of mice. This knowledge will be used to identify liver transplant patients with reduced rejection risk.
The Crisis in International Heritage Conservation in an Age of Shifting Global Power. This project responds to the current crisis in international heritage conservation at a time of shifting global power. The flagship of heritage conservation, the world heritage system, faces multiple pressures and agendas that endanger sites and politicise decision-making at all levels, from local to global. This project focuses on four iconic sites, Abu Simbel, Angkor, Bagan and Sumatran Rainforests, and the w ....The Crisis in International Heritage Conservation in an Age of Shifting Global Power. This project responds to the current crisis in international heritage conservation at a time of shifting global power. The flagship of heritage conservation, the world heritage system, faces multiple pressures and agendas that endanger sites and politicise decision-making at all levels, from local to global. This project focuses on four iconic sites, Abu Simbel, Angkor, Bagan and Sumatran Rainforests, and the world heritage system itself, to reveal how pressures have grown and shifted since World War II, how they operate at multiple scales and what new expertise might be introduced. It will produce a report for UNESCO and publications that include recommendations for solving challenges that threaten international heritage conservation today.Read moreRead less
Creating A Culture Of Safety And Respect: A Controlled, Mixed Methods Study Of The Effectiveness Of A Behavioural Accountability Intervention To Reduce Unprofessional Behaviours
Funder
National Health and Medical Research Council
Funding Amount
$875,978.00
Summary
Unprofessional behaviours among health professionals are common and are associated with increased patient dissatisfaction and medicolegal risk. Addressing these behaviours is a national issue. Ethos is a structured accountability system involving a process of early, non-punitive and tiered intervention and will be introduced across four Australian hospitals. This research will be the first controlled study to assess the effectiveness of the Ethos program to improve patient safety in Australia.
Nuclear Nation: a contemporary archaeology of Australia's atomic heritage. The history of nuclear science in Australia is of growing interest to scholars, however the physical remains of this controversial legacy are yet to be investigated. This interdisciplinary project would bring together leading academics, curators, scientists and First Nations researchers, using innovative contemporary archaeology approaches, to generate new understandings of the significance of Australia’s atomic heritage ....Nuclear Nation: a contemporary archaeology of Australia's atomic heritage. The history of nuclear science in Australia is of growing interest to scholars, however the physical remains of this controversial legacy are yet to be investigated. This interdisciplinary project would bring together leading academics, curators, scientists and First Nations researchers, using innovative contemporary archaeology approaches, to generate new understandings of the significance of Australia’s atomic heritage in global context. Expected outcomes include improved capacity for heritage management, and new resources and methods for understanding and interpreting Australia’s role in the Nuclear Age. This should generate substantial benefits for the Partner Organisations, and for Australia's tourism and cultural sectors more broadly.Read moreRead less
Snails to the rescue! Conservation of Australia’s island invertebrates. This project aims to deliver an exemplar industry network model for conservation on Australia’s islands which are hotspots both of biodiversity and of extinctions. Protecting species on islands is therefore key to securing Australia’s biodiversity. We will secure Norfolk Island's 60 species of land snails via in situ and ex situ conservation with six key industry partners. The project expects to unite conservation actions ac ....Snails to the rescue! Conservation of Australia’s island invertebrates. This project aims to deliver an exemplar industry network model for conservation on Australia’s islands which are hotspots both of biodiversity and of extinctions. Protecting species on islands is therefore key to securing Australia’s biodiversity. We will secure Norfolk Island's 60 species of land snails via in situ and ex situ conservation with six key industry partners. The project expects to unite conservation actions across research, governments, and industry. Expected outcomes of this project include Norfolk Island emerging as a leader in global conservation. This should provide significant benefits such as a model for conservation that is applicable to thousands of isolated, range-restricted invertebrate species across Australia.Read moreRead less
Mid-Career Industry Fellowships - Grant ID: IM230100371
Funder
Australian Research Council
Funding Amount
$1,043,792.00
Summary
The plight of the bogong moth: a model for conservation in Australia. This project aims to direct conservation actions for the bogong moth, an endangered species of profound cultural, ecological, and economic importance to Australians. Although iconic and famous for their epic migration to the Australian Alps, the bogong moth's distribution and flyways are unknown making conservation actions impossible. This project expects to forge the key partnerships and harness public enthusiasm to generate ....The plight of the bogong moth: a model for conservation in Australia. This project aims to direct conservation actions for the bogong moth, an endangered species of profound cultural, ecological, and economic importance to Australians. Although iconic and famous for their epic migration to the Australian Alps, the bogong moth's distribution and flyways are unknown making conservation actions impossible. This project expects to forge the key partnerships and harness public enthusiasm to generate the data needed for conservation actions via a National Bogong Moth Observatory. The expected outcomes of this project are enhanced capacity to identify and mitigate threats to bogong moths. This should provide significant benefits such as a highly transferable model for continent-wide conservation in Australia.Read moreRead less
A Novel Macrophage Lineage In Inflammation And Cancer
Funder
National Health and Medical Research Council
Funding Amount
$772,857.00
Summary
Macrophages are an important haematopoietic cell type that has been implicated in inflammatory and cancerous diseases. In our preliminary work we have discovered a new macrophage subset, termed the perivascular macrophage, in breast cancer. The aim of this proposal is to investigate the origin of these cells, and the role they play in breast cancer. This will tell us how we might be able to manipulate the functions of these cells in order to curtail breast cancer progression.
Activation Of BMP4 Signalling To Inhibit Breast Cancer Metastasis
Funder
National Health and Medical Research Council
Funding Amount
$748,742.00
Summary
The spread of cancer cells to other organs is a common cause of breast cancer-related death in women. Current therapies for advanced breast cancer are often palliative since the secondary tumours become resistant to the chemotherapy. Here, we are using preclinical models of advanced breast cancer to develop a treatment that should be effective in patients with secondary tumours and should reduce the risk of dying of this disease.
How Do Bone-active Drugs Increase Patient Survival?
Funder
National Health and Medical Research Council
Funding Amount
$613,952.00
Summary
Bisphosphonates are a class of drugs used to prevent bone destruction in diseases such as osteoporosis. Evidence is emerging that these drugs also act on cells outside the skeleton to have additional beneficial effects, for example prolonging patient survival. This project will identify the cells affected and the mechanisms involved. With this knowledge, these drugs could be used more effectively and in different ways for the prevention or treatment of cancer and chronic human illnesses.