Regulation Of Key Pathways Causing Peri-implant Bone Loss.
Funder
National Health and Medical Research Council
Funding Amount
$403,639.00
Summary
The failure of bone prostheses is becoming a major health problem in our aging population. Despite the impressive success of joint replacement surgery, a significant number of arthroplasties fail. It is now apparent that most implants fail due to bone loss around them which leads to loosening. This project aims to obtain a better understanding of the causes of implant failure and find ways to extend the life of these implants .
Nuclear Nation: a contemporary archaeology of Australia's atomic heritage. The history of nuclear science in Australia is of growing interest to scholars, however the physical remains of this controversial legacy are yet to be investigated. This interdisciplinary project would bring together leading academics, curators, scientists and First Nations researchers, using innovative contemporary archaeology approaches, to generate new understandings of the significance of Australia’s atomic heritage ....Nuclear Nation: a contemporary archaeology of Australia's atomic heritage. The history of nuclear science in Australia is of growing interest to scholars, however the physical remains of this controversial legacy are yet to be investigated. This interdisciplinary project would bring together leading academics, curators, scientists and First Nations researchers, using innovative contemporary archaeology approaches, to generate new understandings of the significance of Australia’s atomic heritage in global context. Expected outcomes include improved capacity for heritage management, and new resources and methods for understanding and interpreting Australia’s role in the Nuclear Age. This should generate substantial benefits for the Partner Organisations, and for Australia's tourism and cultural sectors more broadly.Read moreRead less
Photography and Reconciliation: the Ngarrindjeri and the SA Museum. The project aims to recover, curate and exhibit a large archive of photographs of national significance created by Aboriginal photographers in the mid-20th century. Working with Ngarrindjeri custodians and the South Australian Museum, it expects to raise the status and diversity of Aboriginal voices in Australian visual culture and public life, undertaking a process of healing. Cultural revitalisation and generational learning v ....Photography and Reconciliation: the Ngarrindjeri and the SA Museum. The project aims to recover, curate and exhibit a large archive of photographs of national significance created by Aboriginal photographers in the mid-20th century. Working with Ngarrindjeri custodians and the South Australian Museum, it expects to raise the status and diversity of Aboriginal voices in Australian visual culture and public life, undertaking a process of healing. Cultural revitalisation and generational learning via the creation of a Living Archive and public exhibition are expected outcomes. Benefits include ensuring longevity of endangered heritage, broadening knowledge of southeastern Aboriginal lives and contributing new evidence to better understand the correlation between cultural revitalisation and community wellbeing.Read moreRead less
The Clinical Significance Of Sex Hormone Crosstalk In Estrogen Receptor Positive Breast Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$1,009,006.00
Summary
Breast cancer is mainly a disease in which the sex hormone estrogen stimulates uncontrolled growth. We have recently discovered that other sex hormones, including progesterone and androgen, can redirect the actions of estrogen in breast cancers to halt growth or make a tumour disappear. This study will examine the complex interaction between all three sex hormones to develop new, more effective strategies for treating breast cancer.
Clinical Outcomes, Safety And Incremental Cost Effectiveness Of Multi-level Airway Surgery In Patients With Moderate-severe Obstructive Sleep Apnea (OSA) Who Have Failed Medical Management
Funder
National Health and Medical Research Council
Funding Amount
$652,794.00
Summary
Obstructive sleep apnoea (OSA) is a serious medical disorder with a high public health cost. OSA can be effectively treated but poor treatment compliance is a major clinical problem. As a consequence many OSA patients remain untreated, with significant implications for their long term health. New effective and safe therapies are needed. We believe that we will demonstrate a relatively straightforward, safe and effective surgical procedure for OSA after primary treatments fail. This will lead to ....Obstructive sleep apnoea (OSA) is a serious medical disorder with a high public health cost. OSA can be effectively treated but poor treatment compliance is a major clinical problem. As a consequence many OSA patients remain untreated, with significant implications for their long term health. New effective and safe therapies are needed. We believe that we will demonstrate a relatively straightforward, safe and effective surgical procedure for OSA after primary treatments fail. This will lead to improved patient outcomes.Read moreRead less
Collecting at the Crossroads: Anthropology, Art & Cultural Change (1939-85). This project will apply current scholarship on museum collecting practices, art and anthropology to produce a better understanding of one of Australia’s most significant, yet little known, collections of Aboriginal art and culture —the Berndt Museum collection. The project will explore the legacy of this collection and generate new ways of appreciating its depth in partnership with the descendants of the Aboriginal peop ....Collecting at the Crossroads: Anthropology, Art & Cultural Change (1939-85). This project will apply current scholarship on museum collecting practices, art and anthropology to produce a better understanding of one of Australia’s most significant, yet little known, collections of Aboriginal art and culture —the Berndt Museum collection. The project will explore the legacy of this collection and generate new ways of appreciating its depth in partnership with the descendants of the Aboriginal people who made it. Focusing on materials collected in inland Australia, we will develop a collaborative means of interrogating the collection. The project will benefit Aboriginal communities and the wider Australian public via the production of on-line resources and public exhibitions celebrating this unique cultural collection.Read moreRead less
A national framework for managing malignant plastics in museum collections. A national framework for managing malignant plastics in museum collections. This collaborative project between three universities, four museums and an art gallery aims to discover how to predict and increase the lifespan of malignant plastics or polymers by studying their identification, deterioration and conservation. 5 to 80% of museum collections, composed of growing numbers of plastic or polymer-based materials, need ....A national framework for managing malignant plastics in museum collections. A national framework for managing malignant plastics in museum collections. This collaborative project between three universities, four museums and an art gallery aims to discover how to predict and increase the lifespan of malignant plastics or polymers by studying their identification, deterioration and conservation. 5 to 80% of museum collections, composed of growing numbers of plastic or polymer-based materials, need better preservation. Conservators do not have much expertise in preserving plastics, which are contemporary and have a relatively short life expectancy. This project intends to provide museums with a model for prioritising and effectively allocating resources to preserve a vulnerable group of collections for future generations.Read moreRead less
The Australian historic shipwreck protection project: the in situ preservation and reburial of a colonial trader - Clarence (1850). The project will use cutting-edge technology to study and preserve an early colonial shipwreck at risk and develop a world-class strategy for the reburial and preservation of endangered historic shipwrecks. The project will help develop new national policy and technical guidelines for site managers of historic shipwrecks and offer new insights into colonial shipbuil ....The Australian historic shipwreck protection project: the in situ preservation and reburial of a colonial trader - Clarence (1850). The project will use cutting-edge technology to study and preserve an early colonial shipwreck at risk and develop a world-class strategy for the reburial and preservation of endangered historic shipwrecks. The project will help develop new national policy and technical guidelines for site managers of historic shipwrecks and offer new insights into colonial shipbuilding.Read moreRead less
Pushing AR Toward Better Outcomes In Breast And Prostate Cancers
Funder
National Health and Medical Research Council
Funding Amount
$998,754.00
Summary
Breast and prostate cancers kill >6000 Australians each year. These cancers are strikingly similar, both driven by hormone receptors that have ‘gone bad’. Current therapies aim to eradicate the receptors. While often effective, therapeutic resistance is common and results in fatal disease. We aim to develop new, less toxic treatments that switch receptor behaviour from good to bad, without destroying them. This should improve quality of life, while preventing drug resistance and loss of lives ....Breast and prostate cancers kill >6000 Australians each year. These cancers are strikingly similar, both driven by hormone receptors that have ‘gone bad’. Current therapies aim to eradicate the receptors. While often effective, therapeutic resistance is common and results in fatal disease. We aim to develop new, less toxic treatments that switch receptor behaviour from good to bad, without destroying them. This should improve quality of life, while preventing drug resistance and loss of lives.Read moreRead less
Pathophysiology And Alternative Preventative Strategy For Breast Cancer Chemotherapy-induced Bone Loss
Funder
National Health and Medical Research Council
Funding Amount
$540,356.00
Summary
Combination cytotoxic chemotherapy is the current optimal approach for treating breast cancer in premenopausal women. However, long-term skeletal defects (osteoporosis and fractures) caused by the chemotherapy have become an increasingly serious problem due to its intensified use and improved patient survival rate. This project seeks to elucidate the mechanisms for chemotherapy-induced bone defects and to initiate development of a preventative treatment using natural bioactive micronutrients.