Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest: A Phase III Multi-Centre Randomised Controlled Trial (The TAME Cardiac Arrest Trial)
Funder
National Health and Medical Research Council
Funding Amount
$2,069,878.00
Summary
The TAME Cardiac Arrest trial will study the ability of higher carbon dioxide (CO2) levels to reduce brain damage, comparing giving patients ‘normal’ to ‘slightly higher than normal’ blood CO2 levels and assessing their ability to return to normal life-tasks. It will be the largest trial ever conducted in heart attack patients in the ICU. This therapy is cost free and, if shown to be effective, will improve thousands of Australian lives, transform clinical practice, and yield major savings.
Reduction Of Oxygen After Cardiac Arrest: The EXACT Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,891,021.00
Summary
We aim to conduct a Phase 3 multi-centre, randomised, controlled trial to determine whether reducing oxygen administration to target a normal level as soon as possible following successful resuscitation from out-of-hospital cardiac arrest, compared to current practice of maintaining 100% oxygen, improves patient survival at hospital discharge.
The Impact Of Introducing Medical Emergency Team On The Reduction Of Hospital Mortality And Other Adverse Events In NSW
Funder
National Health and Medical Research Council
Funding Amount
$581,827.00
Summary
High numbers of patients suffer an adverse event or die in hospitals needlessly. Summoned by a set of pre-specified criteria, a Medical Emergency Team (MET) rapidly respond to patients on general wards to prevent further deterioration. Previous studies have shown its impact on reducing cardiac arrests but limited high level evidence on reducing hospital deaths. Current study uses linked administrative databases and well-established indicators to assess the impact of introduction of a MET in NSW.
The Evaluation Of A Statewide Innovative Patient Safety Improvement System On Reducing Hospital Mortality And Other Adverse Events - A Population-based Mixed-method Study
Funder
National Health and Medical Research Council
Funding Amount
$724,555.00
Summary
Research indicates that one in ten patients admitted to hospital suffered an adverse event. Studies have shown that the adverse clinical outcomes (e.g. cardiac arrest or death) often exhibit early warning signs such as slow deterioration of vital signs hours before such an event. Clinical Excellence Commission of NSW implemented a world-first standardised patient safety system (i.e., Between the Flag) to address the issues. We aim to provide an evaluation of the effectiveness of this system.
Clinical, Genetic And Psychosocial Aspects Of Sudden Cardiac Death
Funder
National Health and Medical Research Council
Funding Amount
$433,423.00
Summary
Sudden cardiac death (SCD) in the young is a tragic complication of a number of genetic heart diseases. Families must deal with profound grief and act on the genetic risk to themselves and other relatives. Clinical management can include the implantable cardioverter defibrillator (ICD) and is the only therapy proven to prevent SCD. This proposal seeks to investigate the clinical, genetic and psychosocial aspects of managing families who present following a SCD, including psychological outcomes o ....Sudden cardiac death (SCD) in the young is a tragic complication of a number of genetic heart diseases. Families must deal with profound grief and act on the genetic risk to themselves and other relatives. Clinical management can include the implantable cardioverter defibrillator (ICD) and is the only therapy proven to prevent SCD. This proposal seeks to investigate the clinical, genetic and psychosocial aspects of managing families who present following a SCD, including psychological outcomes of life-saving ICD therapy.Read moreRead less
The RINSE Trial: The Rapid Infusion Of Cold Normal SalinE By Paramedics During CPR
Funder
National Health and Medical Research Council
Funding Amount
$708,241.00
Summary
Sudden cardiac arrest is a common event in the community. Therapeutic hypothermia decreases the brain injury caused by the cardiac arrest and is currently used in the hospital after successful resuscitation. However, there may be better outcomes if the brain is cooled by paramedics during resuscitation. We will compare survival rates for those patients cooled early by paramedics using an infusion of ice-saline during cardiac arrest with those patients who are later cooled by the hospital.
Regulation Of RyR2 Channels By Calmodulin In Healthy And Diseased Hearts
Funder
National Health and Medical Research Council
Funding Amount
$614,421.00
Summary
In the heart, RyR2 is responsible for intracellular Ca2+ release. The RyR2 is comprised of a Ca2+ channel and accessory proteins such as CaM that regulate channel activity. Evidence suggests that RyR2 regulation by CaM is altered in heart failure and human arrhythmia syndromes, but there has been no direct evidence for this. We will provide this direct evidence plus determine how CaM regulates RyR2 channels and intracellular Ca2+ release and how this leads to cardiac arrhythmias.
Ryanodine Receptor Inhibitors As Therapy For Ca2+ Store Overload Induced Arrhythmias
Funder
National Health and Medical Research Council
Funding Amount
$555,892.00
Summary
This study investigates a new therapeutic action recently discovered for flecainide, an antiarrhythmic agent that we find to completely prevent and inherited form of stress-induced arrhythmias called CPVT. The findings will provide the first detailed mechanistic understanding of an antiarrhythmic drug, findings that will also give a new direction for drug design to control common arrhythmias such as occur in diseases such as coronary artery disease.
CCR4/NOT Complex Is A Conserved Regulator Of Heart Function
Funder
National Health and Medical Research Council
Funding Amount
$467,567.00
Summary
Cardiovascular diseases kill an Australian every 11 minutes. The goal of this proposal is to characterize the role of the conserved heart regulators in cardiac function and disease. Our combined multi-species and informatics approach has identified a major disease locus for sudden cardiac death in humans, which we propose to characterize. This work can lead to new classes of drugs to improve cardiac health and also aid in early diagnosis of patients susceptible to sudden cardiac death.
Targeting Lipids Regulated In A Setting Of Physiological Cardiac Hypertrophy
Funder
National Health and Medical Research Council
Funding Amount
$489,970.00
Summary
Existing heart failure therapies largely delay heart failure progression rather than reversing the disease. New therapeutic strategies with the ability of improving function of the failing heart are thus greatly needed. The primary goal of this study is to determine whether lipids that are secreted by the heart in a setting of “good” physiological heart growth (as occurs with exercise) can be targeted to restore function of the failing heart.