Targeting PI3K-regulated MicroRNAs To Treat Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$532,593.00
Summary
Current therapeutics largely delay heart failure progression rather than regressing it. New therapeutic strategies with the capability of improving function of the failing heart are thus greatly needed. The primary goal of this study is to determine whether novel regulatory genes can enhance cardiac function in a setting of heart failure. Ultimately, technologies that target these genes may lead to innovative pharmacotherapies in the clinical management of heart failure.
Targeting PI3K-regulated Small Non-coding RNAs To Restore Cardiac Function
Funder
National Health and Medical Research Council
Funding Amount
$610,204.00
Summary
Heart failure affects approximately 2.4% of the adult population and over 11% of people over 80 years old. The majority of existing therapies slow, rather than reverse heart failure progression. The primary goal of this study is to determine whether regulating novel regulatory genes can enhance cardiac function in a setting of heart failure. Ultimately, technologies that target these genes may lead to innovative pharmacotherapies in the clinical management of heart failure.
Australian Resuscitation Outcomes Consortium [AUS-ROC] CRE
Funder
National Health and Medical Research Council
Funding Amount
$2,668,571.00
Summary
The Australian Resuscitation Outcomes Consortium (Aus-ROC) will be modelled on the highly successful North American Resuscitation Outcomes Consortium. The mission of Aus-ROC will be to conduct clinical trials and observational studies into the emergency management of out-of-hospital cardiopulmonary arrest. Building on our existing collaborative partnerships, our goal is to improve patient outcomes and build the research capacity in prehospital emergency care.
Conjugate natural convection boundary layers. Conjugate natural convection systems occur when a conducting vertical wall separates fluids at different temperatures (that is at a window separating the interior of a room from the outside or when a container of fluid is placed in a refrigerator). This project will provide accurate predictions of such flows together with scaling relations.
Enhancing passive cooling using flexible baffles. The project aims to develop a novel passive strategy using fluid-structure-thermal interactions to enhance passive cooling by natural convection and improve the energy efficiency of engineering systems. Comparing to the existing strategies, the new strategy does not require driving fan or pump and is quiet, reliable, self-adaptive and economical. The Multiphysics embodied in the proposal is at the leading edge of the field. Expected outcomes incl ....Enhancing passive cooling using flexible baffles. The project aims to develop a novel passive strategy using fluid-structure-thermal interactions to enhance passive cooling by natural convection and improve the energy efficiency of engineering systems. Comparing to the existing strategies, the new strategy does not require driving fan or pump and is quiet, reliable, self-adaptive and economical. The Multiphysics embodied in the proposal is at the leading edge of the field. Expected outcomes include advanced understanding of the complex Multiphysics and design rules for enhancing passive cooling by natural convection using flexible baffles. The research is expected to bring direct economic benefit to relevant industry and significant environmental and social benefit to the general public.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100203
Funder
Australian Research Council
Funding Amount
$956,700.00
Summary
Novel diagnostics capabilities in reacting, particle-laden flows. This project aims to establish innovative capabilities for advanced diagnostics techniques to be applied in reacting, particle-laden flows over a range of pressures. The complementary measurements are expected to provide an unprecedented understanding of the dynamics of liquid fragments and solid particles in flames. The resulting data, and improved knowledge, will set the framework for more effective predictive methods that assis ....Novel diagnostics capabilities in reacting, particle-laden flows. This project aims to establish innovative capabilities for advanced diagnostics techniques to be applied in reacting, particle-laden flows over a range of pressures. The complementary measurements are expected to provide an unprecedented understanding of the dynamics of liquid fragments and solid particles in flames. The resulting data, and improved knowledge, will set the framework for more effective predictive methods that assist in the design of cleaner and efficient processes that benefit a range of applications, from engine design to the generation of new fuels, and the flame synthesis of novel materials.Read moreRead less
Large Scale Natural Convection Boundary Layers with Non-Boussinesq Effects. This proposal aims to understand and predict heat transfer by turbulent natural convection in two scenarios, firstly at very large environmental scales, such as occur on melting Antarctic ice sheets, and secondly convection involving very large temperature differences such as occur in solar thermal power plants and industrial processes. These natural convection flow regimes are incredibly difficult to investigate directl ....Large Scale Natural Convection Boundary Layers with Non-Boussinesq Effects. This proposal aims to understand and predict heat transfer by turbulent natural convection in two scenarios, firstly at very large environmental scales, such as occur on melting Antarctic ice sheets, and secondly convection involving very large temperature differences such as occur in solar thermal power plants and industrial processes. These natural convection flow regimes are incredibly difficult to investigate directly but by focusing on the fundamental dynamics of the turbulent flows using large scale numerical simulations and innovative experiments, the project is expected to develop better analytical and computational models which will underpin improvements in
global ocean models and improve energy efficiency.Read moreRead less
Reducing the energy consumed by lighting with gaze-dependent illumination. Lighting consumes approximately 18% of electricity, but only a fraction of the light emitted into buildings actually supports occupants’ vision – the rest is wasted. This research aims to reduce the energy consumed by lighting by developing strategies for illuminating only the portions of architectural environments that are visible to occupants, thereby reducing unnecessary light. The impacts of gaze-dependent lighting on ....Reducing the energy consumed by lighting with gaze-dependent illumination. Lighting consumes approximately 18% of electricity, but only a fraction of the light emitted into buildings actually supports occupants’ vision – the rest is wasted. This research aims to reduce the energy consumed by lighting by developing strategies for illuminating only the portions of architectural environments that are visible to occupants, thereby reducing unnecessary light. The impacts of gaze-dependent lighting on energy consumption and the visual environment will be characterized and design guidelines will be generated to facilitate the development of innovative lighting systems that consume less energy by producing less light, without negatively impacting the visual experiences of building occupants.Read moreRead less
An Innovative Powertrain Architecture and Optimal Energy Management for Plug-in Hybrid Electric Vehicles. Plug-in hybrid electric vehicle technologies will significantly reduce the dependence of vehicles on fossil fuels, thereby reducing their emissions of carbon and other pollutants. The project will produce new knowledge in automotive engineering, software tools for vehicle design and a novel powertrain architecture with key components almost ready for commercial application. The research will ....An Innovative Powertrain Architecture and Optimal Energy Management for Plug-in Hybrid Electric Vehicles. Plug-in hybrid electric vehicle technologies will significantly reduce the dependence of vehicles on fossil fuels, thereby reducing their emissions of carbon and other pollutants. The project will produce new knowledge in automotive engineering, software tools for vehicle design and a novel powertrain architecture with key components almost ready for commercial application. The research will directly contribute to the use of green energy and the reduction of vehicles' harmful environmental impacts. The nation will benefit from new economic activity, such as increased exports of automotive parts and components, and from strengthening its position as a world leader in reducing carbon emissions.Read moreRead less
Optimising Heart Disease Prevention And Management
Funder
National Health and Medical Research Council
Funding Amount
$4,647,175.00
Summary
As we become older and risk factors such as obesity become more common, our biggest contributor to death and disability, cardiovascular disease (including heart disease), will continue to exert an enormous burden on our health care system and society. We will extend our ground-breaking research on multidisciplinary teams to create new and innovative health care programs to optimise the prevention and management of new heart disease and chronic forms of heart disease.