Investigating the structure, function and inhibition of the adrenaline-synthesizing enzyme PNMT. We determined the structure of the enzyme PNMT and we plan to use this in the design of PNMT inhibitors to enable us to probe the role of adrenaline and PNMT in the central nervous system. As part of this work, we will further characterise the structure of PNMT by crystallography and mutagenesis. The significance is that designed PNMT inhibitors could eventually be used as leads in the development of ....Investigating the structure, function and inhibition of the adrenaline-synthesizing enzyme PNMT. We determined the structure of the enzyme PNMT and we plan to use this in the design of PNMT inhibitors to enable us to probe the role of adrenaline and PNMT in the central nervous system. As part of this work, we will further characterise the structure of PNMT by crystallography and mutagenesis. The significance is that designed PNMT inhibitors could eventually be used as leads in the development of compounds with novel pharmacological and therapeutic activity. Furthermore, our analysis of PNMT will determine rules that can be applied to the design of new methyltransferase enzymes with novel functions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100181
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Strengthening merit-based access and support at the new National Computing Infrastructure petascale supercomputing facility. World-leading high-performance computing is fundamental to Australia's international research success. This facility will provide access to the new National Computational Infrastructure facility by world-leading researchers from six research universities, and sustain ground-breaking work in an increasingly competitive environment.